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  • 1
    Electronic Resource
    Electronic Resource
    Extension of the SIMLA Package for Generating Pedigrees with Complex Inheritance Patterns: Environmental Covariates, Gene-Gene and Gene-Environment Interaction (2005)
    Berkeley, Calif. : Berkeley Electronic Press (now: De Gruyter)
    Statistical applications in genetics and molecular biology 4.2005, 1, art15 
    Details
    ISSN: 1544-6115
    Source: Berkeley Electronic Press Academic Journals
    Topics: Biology
    Notes: We have previously distributed a software package, SIMLA (SIMulation of Linkage and Association), which can be used to generate disease phenotype and marker genotype data in three-generational pedigrees of user-specified structure. To our knowledge, SIMLA is the only publicly available program that can simulate variable levels of both linkage (recombination) and linkage disequilibrium (LD) between marker and disease loci in general pedigrees. While the previous SIMLA version provided flexibility in choosing many parameters relevant for linkage and association mapping of complex human diseases, it did not allow for the segregation of more than one disease locus in a given pedigree and did not incorporate environmental covariates possibly interacting with disease susceptibility genes. Here, we present an extension of the simulation algorithm characterized by a much more general penetrance function, which allows for the joint action of up to two genes and up to two environmental covariates in the simulated pedigrees, with all possible multiplicative interaction effects between them. This makes the program even more useful for comparing the performance of different linkage and association analysis methods applied to complex human phenotypes. SIMLA can assist investigators in planning and designing a variety of linkage and association studies, and can help interpret results of real data analyses by comparing them to results obtained under a user-controlled data generation mechanism.A free download of the SIMLA package is available at http://wwwchg.duhs.duke.edu/software.
    Type of Medium: Electronic Resource
    URL: http://www.bepress.com/sagmb/vol4/iss1/art15
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  • 2
    Electronic Resource
    Electronic Resource
    Phagocytosis, oxidative burst, and killing of Candida dubliniensis and Candida albicans by human neutrophils (2000)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 191 (2000), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Candida dubliniensis is a phylogenetically closely related species to Candida albicans. So far virtually nothing is known about the virulence factors of C. dubliniensis. Cell surface hydrophobicity (CSH) plays a critical role in adhesion of microorganisms to phagocytic cells; hydrophobic cells of C. albicans have been reported to be less sensitive to phagocytic killing than hydrophilic cells. C. dubliniensis displays CSH at 37°C in contrast to C. albicans. To elucidate this issue, we determined levels of phagocytosis, oxidative burst and killing by human neutrophils of C. dubliniensis (n=10) compared to C. albicans (n=10) both cultured at 37°C. Obtained test results revealed no statistically significant differences between these two yeast species for the level of phagocytosis (77.3 vs. 76.2% after 60 min), evoked oxidative burst (64.5 vs. 67.3% after 30 min) and killing (72.7 vs. 73.1% after 240 min). Therefore, human neutrophils can be considered to be equally efficient against these two yeast species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.2000.tb09332.x
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  • 3
    Electronic Resource
    Electronic Resource
    Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis (2007)
    [s.l.] : Nature Publishing Group
    Nature genetics 39 (2007), S. 1083-1091 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Multiple sclerosis is a demyelinating neurodegenerative disease with a strong genetic component. Previous genetic risk studies have failed to identify consistently linked regions or genes outside of the major histocompatibility complex on chromosome 6p. We describe allelic association of a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng2103
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  • 4
    Electronic Resource
    Electronic Resource
    Breast cancer risk assessment: use of complete pedigree information and the effect of misspecified ages at diagnosis of affected relatives (1998)
    Springer
    Human genetics 〈Berlin〉 102 (1998), S. 348-356 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050704
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  • 5
    Electronic Resource
    Electronic Resource
    Die Bindungstheorie und ihre Relevanz für die Psychotherapie (1996)
    Springer
    Psychotherapeut 41 (1996), S. 139-150 
    Details
    ISSN: 0935-6185
    Keywords: Schlüsselwörter Bindung ; Bindungstheorie ; Entwicklungspsychologie ; Bindung im Erwachsenenalter ; Erfassung von Bindung bei Erwachsenen ; Key words Attachment ; Attachment theory ; Developmental Psychology ; Adult attachment ; Assessment of adult attachment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology , Medicine
    Description / Table of Contents: Summary Attachment theory, originally developed by John Bowlby, becomes increasingly relevant in the field of psychotherapy (research). This review starts with a definition of central concepts and hypotheses of this theory and summarizes results regarding the development as well as correlates of attachment, mainly from research in developmental psychology. Related to adults, attachment theory has to be reconceptualized which is done in another part of this paper. Finally, some common methods for the assessment of adult attachment are described which play an important role in clinical studies (these will be the content of the part 2 of this review).
    Notes: Zusammenfassung Die ursprünglich von John Bowlby entwickelte Bindungstheorie gewinnt zunehmend an Relevanz im Bereich der Psychotherapie(forschung). Diese Übersicht beginnt mit einer Klärung der zentralen Begriffe und Annahmen dieser Theorie und faßt einige Befunde zur Entwicklung und den Korrelaten von Bindung zusammen, die vornehmlich aus entwicklungspsychologischen Untersuchungen stammen. Übertragen auf Erwachsene, bedürfen die Konzepte der Bindungstheorie einer Revision, die in dieser Arbeit skizziert wird. Schließlich werden auf dieser Basis einige heute übliche Methoden zur Erfassung von Bindungsstilen und Bindungsverhalten im Erwachsenenalter dargestellt, die bei Untersuchungen im klinischen Feld (Inhalt des 2. Teils der Übersichtsarbeit) eine wichtige Rolle spielen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002780050028
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  • 6
    Electronic Resource
    Electronic Resource
    Die Bindungstheorie und ihre Relevanz für die Psychotherapie (1997)
    Springer
    Psychotherapeut 42 (1997), S. 1-16 
    Details
    ISSN: 0935-6185
    Keywords: Schlüsselwörter Bindung ; Bindungstheorie ; Klinische Implikationen ; Psychoanalyse ; Psychosomatik ; Krankheitsverarbeitung ; Psychotherapie(forschung) ; Key words Attachment ; Attachment theory ; Clinical implications ; Psychoanalysis ; Psychosomatics ; Coping ; Psychotherapy (Research)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology , Medicine
    Description / Table of Contents: Summary Whilst the first part of the review about the relevance of attachment theory covered the basic principles and methods of attachment research, this second part deals with possible implications of the theory within the field of psychotherapy and psychosomatics. Consideration of its general clinical relevance and of the relationship between attachment theory and psychoanalysis forms the basis for a description of the usefulness results of attachment research might have in psychotherapeutic practice. Summaries of studies dealing with the importance of attachment characteristics for the development of psychosomatic disorders and for coping with illness and stress and studies combining attachment styles with psychopathology will follow. The last part of the review refers to the importance of the theory for psychotherapy and psychotherapy research.
    Notes: Zusammenfassung Während im ersten Teil der Übersicht über die Relevanz der Bindungstheorie Grundlagen und Methoden der Bindungsforschung skizziert wurden, werden nun die möglichen Implikationen der Theorie für die Psychotherapie und Psychosomatik erörtert. Überlegungen zur allgemeinen klinischen Relevanz und zum Verhältnis der Bindungstheorie zur Psychoanalyse bilden die Basis für die Darstellung konkreter Anwendungen von Ergebnissen der Bindungsforschung in der therapeutischen Praxis. Es folgen zusammenfassende Darstellungen von Untersuchungen, die sich mit der Bedeutung von Bindungscharakteristika für die Entwicklung psychosomatischer Störungen und die Krankheits- bzw. Streßverarbeitung befassen sowie von Studien, in denen Bindungscharakteristika psychischen Störungen zugeordnet wurden. Schließlich wird die Bedeutung der Theorie für die Psychotherapie und die Psychotherapieforschung dargestellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002780050048
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