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  • 1
    Electronic Resource
    Electronic Resource
    A reply (2004)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 59 (2004), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.2004.03936.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Transient radicular irritation after single subarachnoid injection of isobaric 2% lignocaine for spinal anaesthesia (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 51 (1996), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Several cases have been reported recently in which symptoms suggestive of transient radicular irritation occurred following the use of hyperbaric 5% lignocaine for spinal anaesthesia. We report on three patients in whom we observed similar symptoms attributable to this kind of radicular irritation following uneventful spinal anaesthesia using isobaric 2% lignocaine. All three patients underwent minor gynaecological procedures and developed burning pains in the buttocks within 24 h of surgery. The long-term outcome was not clear for all the patients, but in at least one the pain disappeared.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1996.tb07710.x
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of epidural analgesia in labour on maternal respiratory function (2004)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 59 (2004), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Lumbar epidural analgesia during labour has gained widespread acceptance. The impact of epidural analgesia based on mixtures of low-dose local anaesthetic solutions and lipophilic opioids on most clinically relevant obstetric outcomes is minimal. Since the pregnant state per se is associated with important alterations in respiration, we assessed whether a subtle degree of motor blockade brought about by epidural analgesia might compromise respiratory function as assessed by spirometry. Sixty consenting parturients receiving epidural analgesia were consecutively included in this prospective study. We performed spirometry during the antepartum visit and in labour after effective epidural analgesia was established; at both assessments the women were pain-free. Values were within normal ranges but increased significantly after effective epidural analgesia; median (IQR [range]) increase for vital capacity 7.4 (3.0–13 [−12–27])% (p 〈 0.001); forced vital capacity 4.4 (1.7–9.8 [−13–26])% (p 〈 0.001); forced expiratory volume in 1 s 5.5 (1.7–8.6 [−14–28])% (p 〈 0.001); and peak expiratory flow rate 2.3 (−1.6–5.8 [−18–16])% (p = 0.01)). We conclude that epidural analgesia for labour significantly improved respiratory function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.2004.03667.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Impact of spinal anaesthesia and obesity on maternal respiratory function during elective Caesarean section (2004)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 59 (2004), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Spinal anaesthesia for Caesarean section has gained widespread acceptance. We assessed the impact of spinal anaesthesia and body mass index (BMI) on spirometric performance. In this prospective study, we consecutively assessed 71 consenting parturients receiving spinal anaesthesia with hyperbaric bupivacaine and fentanyl for elective Caesarean section. We performed spirometry during the antepartum visit (baseline), immediately after spinal anaesthesia, 10–20 min, 1 h, 2 h after the operation, and after mobilisation (3 h). Baseline values were within normal ranges. There was a significant decrease in all spirometric parameters after effective spinal anaesthesia that persisted throughout the study period. The decrease in respiratory function was significantly greater in obese (BMI 〉 30 kg.m−2) than in normal-weight parturients (BMI 〈 25 kg.m−2), e.g. median (IQR) vital capacity directly after spinal anaesthesia; −24 (−16 to −31)% vs. −11 (−6 to −16)%, p 〈 0.001 and recovery was significantly slower. We conclude that both spinal anaesthesia and obesity significantly impair respiratory function in parturients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.2004.03832.x
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  • 5
    Electronic Resource
    Electronic Resource
    Fatal infantile encephalopathy with olivopontocerebellar hypoplasia and micrencephaly (1993)
    Springer
    Acta neuropathologica 85 (1993), S. 394-399 
    Details
    ISSN: 1432-0533
    Keywords: Infantile olivopontocerebellar hypoplasia ; Encephalopathy ; Micrencephaly
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report three siblings born with severe neonatal encephalopathy, manifested clinically by microcephaly, myoclonus, and muscular hypertonus. Karyotypic analyses and all biochemical investigations were unrevealing. All three patients died during infancy. Postmortem examination of the brain in one child disclosed severe neuronal loss in the inferior olives and the pontine nuclei. There was also severe hypoplasia of the cerebellum and micrencephaly. There was diffuse gliosis of the white matter in all areas of the brain. We believe this may represent a previously undescribed form of familial infantile encephalopathy with olivopontocerebellar hypoplasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334450
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Experimentelle Daten zu den Interaktionen von a2-Adrenozeptoragonisten mit Anästhetika, Analgetika, Lokalanästhetika (1996)
    Springer
    Der Schmerz 10 (1996), S. 14-20 
    Details
    ISSN: 1432-2129
    Keywords: Schlüsselwörterα2-Adrenozeptor-Agonisten: Clonidin ; Opioide: Morphin ; Lokalanästhetika: Bupivacain ; Anästhesietechnik: regional ; rückenmarksnah ; Pharmakologie: Interaktionen: additiv ; synergistisch ; Nozizeption ; Key wordsα2-Adrenoceptor agonists ; Opioids ; Local anaesthetics ; Regional anaesthesia ; Neuraxial anaesthesia ; Interactions ; Additive effect ; Synergistic effect ; Nociception
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The interactions of α2-adrenoceptor agonists with anaesthetics, analgesics and local anaesthetics are not only of practical importance in many areas of anaesthesia and pain therapy, but also of significant theoretical interest. Laboratory investigations and animal research allow us to study the pharmacological mechanisms of these drug interactions by using the tools of molecular biology. This may lead to the establishment of a scientific basis allowing the definition of rational drug therapies. In the first part of this overview, recent data on local anaesthetic effects of α2-adrenoceptor agonists on peripheral nerve conduction and their interaction with local anaesthetics are presented. Some important experimental work focusing on additive and synergistic spinal interactions of α2-adrenoceptor agonists with opioids and some other agents are then discussed. Finally, there is a brief reference to the central role of the spinal cord in mediating and controlling nociception.
    Notes: Zusammenfassung Die Interaktionen der α2-Adrenozeptoragonisten mit Anästhetika, Analgetika und Lokalanästhetika sind nicht nur von praktischer Bedeutung für viele Bereiche der Anästhesie und Schmerztherapie, sondern auch von theoretischem Interesse, weil gerade im Laborexperiment und im Tierversuch wichtige molekularbiologische Mechanismen und physiologische Grundlagen der pharmakologischen Interaktionen untersucht und dargestellt werden können. In dieser Übersichtsarbeit werden Untersuchungen zu den lokalanästhetischen Effekten der α2-Adrenozeptoragonisten am peripheren Nerven und ihre Interaktionen mit Lokalanästhetika vorgestellt. Dann werden einige laborexperimentelle Arbeiten zusammengefaßt, in denen additive und supraadditive spinale Interaktionen von α2-Adrenozeptoragonisten mit Opioiden, Physostgimin, Carbachol, Adenosin, Midazolam und Ketorolac nachgewiesen werden konnten. Schließlich soll die zentrale Rolle des Rückenmarks im Rahmen der physiologischen Kontrolle der Nozizeption kurz diskutiert werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004820050015
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    Paper (German National Licenses)
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