Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Pancreatic exocrine function in patients with type 1 and type 2 diabetes mellitus (2000)
    Springer
    Acta diabetologica 37 (2000), S. 105-110 
    Details
    ISSN: 1432-5233
    Keywords: Key words Chronic pancreatitis ; Elastase 1 ; Exocrine pancreatic function ; Diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Reduced exocrine pancreatic function has been observed in a high percentage of patients with type 1 diabetes in the past. There are only few data for type 2 diabetes available and they are contradictory. In this study we investigated exocrine pancreatic function in 105 controls and 114 with type 1 or type 2 diabetes mellitus by means of an indirect test (faecal elastase-1 concentration). This test has good sensitivity and specificity for moderate and severe pancreatic insufficiency as compared to the gold standard. Reduced faecal elastase-1 concentrations were found in 56.7% of type 1 patients, 35% of type 2 patients and 18.1% of the controls. Elastase-1 concentrations did not correlate with alcohol consumption, diabetes duration or diabetes therapy. The data found for type 1 patients correspond to those reported in earlier studies. The results for type 2 diabetics show that exocrine pancreatic function is also impaired in a high percentage in this group of patients. Pathogenic concepts to explain these findings as consequences of diabetes complications or insulin deficiency are still under debate. Observations from autopsies and the data of the controls in this study suggest that chronic pancreatitis might be a common problem. In consequence, diabetes secondary to exocrine disease could be much more frequent than believed so far.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005920070011
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Diagnostic Relevance of Interleukin Pattern, Acute-Phase Proteins, and Procalcitonin in Early Phase of Post-ERCP Pancreatitis (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 1763-1769 
    Details
    ISSN: 1573-2568
    Keywords: ENDOSCOPIC RETROGRADECHOLANGIOPANCREATOGRAPHY ; ACUTE PANCREATITIS ; PROCALCITONIN ; CYTOKINES ; INTERLEUKINS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Post-endoscopic retrogradecholangiopancreatography (ERCP) pancreatitis has beensuggested as a model for acute pancreatitis (AP), whichallows evaluation of early alterations in the timecourse of the disease. The influence of the clinical courseon procalcitonin (PCT), serum amyloid A (SAA), andseveral proinflammatory and inhibitory cytokines wasevaluated in patients with AP following ERCP. Blood samples were prospectively collected frompatients undergoing ERCP. The incidence of ERCP-inducedpancreatic damage, defined as abdominal complaints, athreefold increase of serum lipase, and elevation of CRP from 〈10 to 〉20 mg/liter was 12.8%(12/94). Only mild clinical courses of acutepancreatitis were observed. PCT significantly increasedin subjects with post-ERCP pancreatitis after 24 hr. However, PCT levels did not exceed 0.5 ng/ml inany patient. Interleukin-1 receptor antagonist (IL-1RA)began to differ from baseline 2 hr after ERCP, followedby interleukin-6 (IL-6, 6 hr), solubilized tumor necrosis factor-α receptor II(sTNF-αRII, 24 hr) and SAA (24 hr). Interleukin 10(IL-10) showed marked interindividual variations with noobvious peak. Among all parameters evaluated, only peak values of IL-6 and IL-10 showedsignificant correlations with the reported pain score(r2 = 0.62/0.78), degree of ampullarirritation (r2 = NS/0.87), and the durationof ERCP (r2 = 0.58/0.76). No correlation was found with the volume of theinjected contrast agent. We conclude that IL-10 and IL-6appear to be useful to monitor patients after ERCP. Theabsence of any PCT elevation in the present study is in accordance with the clinical courseof the patients who suffered from mild pancreatic damagewithout systemic or infectious complications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018887704337
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...