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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 95 (1991), S. 6871-6879 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 57 (1990), S. 49-51 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Ion beam induced deposition of carbon films has been studied as a function of temperature and pressure for both 2-bromo vinyl benzene and 2-bromo ethyl benzene. In contrast to recently published results involving vinyl and ethyl benzene, deposition is possible for both materials at and below room temperature for a wide range of pressures. Further, deposition yield for each material scales directly with its vapor pressure at the deposition temperature. This behavior shows that physical adsorption plays the dominant role in determining deposition properties. In addition, the yield of 2-bromo vinyl benzene is consistently higher than 2-bromo ethyl benzene at a given normalized pressure. The importance of the double bond on the vinyl substituent observed in previous work is simply a manifestation of enhanced physical adsorption due to the presence of this double bond.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Microelectronic Engineering 9 (1989), S. 97-100 
    ISSN: 0167-9317
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0167-9317
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0167-9317
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0584
    Keywords: Cytogenetic studies ; AML ; Prognostic value
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Between 1981 and 1986 cytogenetic studies of bone marrow and/or blood cells in 139 patients with de novo acute myeloid leukemia (AML) were performed. The overall incidence of chromosomal aberrations was 53%, and this was not significantly influenced by sex, age nor the FAB classification. The aberrations most often found were: complex anomalies (n=13), t(8; 21) (n=10), trisomy 8 (n=9), monosomy 7 (n=6), monosomy 5, 5q-, trisomy 11, 12p- (n=4) and trisomy 6, 11q-, inv [16] (n=3). The prognostic significance of chromosomal findings was evaluated in 112 patients treated by combination chemotherapy. The chromosomal status NN, AN, AA did neither significantly influence complete remission rate (NN: 68%, AN: 71%, AA: 60%) nor mean survival (NN: 24, AN: 26.6, AA: 35.6 months). On the other hand, certain types of chromosomal anomalies were of prognostic value. CR was obtained in all 10 patients with t(8; 21) but only in 2 out of 9 patients with complex aberrations. Median duration of CR in patients with t(8; 21) was significantly longer than in patients with a normal karyotype (30 vs 7 months).
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0584
    Keywords: Acute nonlymphocytic leukemia ; Multiple myeloma ; Trisomy 8
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of acute nonlymphocytic leukemia (ANLL) occurring 2 years after the diagnosis of multiple myeloma (MM) that had been treated by only one course of melphalan/prednisone chemotherapy is reported. Cytogenetic and fluorescence in situ hybridization analysis of peripheral blood cells revealed trisomy 8 as the sole cytogenetic defect at the time of diagnosis of ANLL. Two years earlier, when MM was diagnosed without any cytological evidence of co-existent myelodysplasia, chromosomal analysis of bone marrow cells showed the same pathological karyotype 47, XY, +8 in 14 of 20 mitoses studied. Our interpretation of this unusual cytogenetic finding is that at the time of diagnosis of MM, in spite of lacking cytological signs of myelodysplasia, an unrecognizable myelodysplastic syndrome must have been present which then evolved to ANLL.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A case of acute nonlymphocytic leukemia (ANLL) occurring 2 years after the diagnosis of multiple myeloma (MM) that had been treated by only one course of melphalan/prednisone chemotherapy is reported. Cytogenetic and fluorescence in situ hybridization analysis of peripheral blood cells revealed trisomy 8 as the sole cytogenetic defect at the time of diagnosis of ANLL. Two years earlier, when MM was diagnosed without any cytological evidence of co-existent myelodysplasia, chromosomal analysis of bone marrow cells showed the same pathological karyotype 47, XY, +8 in 14 of 20 mitoses studied. Our interpretation of this unusual cytogenetic finding is that at the time of diagnosis of MM, in spite of lacking cytological signs of myelodysplasia, an unrecognizable myelodysplastic syndrome must have been present which then evolved to ANLL. Key words Acute nonlymphocytic leukemia · Multiple myeloma · Trisomy 8
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-2129
    Keywords: Schlüsselwörter Chronische Rückenschmerzen ; Multimodales Behandlungsprogramm ; Kognitiv-behaviorale Verhaltenstherapie ; Depressivität ; Krankheitsbewältigung ; Subjektive Beeinträchtigung ; Key words Chronic low back pain ; Multimodal treatment program ; Cognitive behavioral modification ; Depression ; Coping ; Disability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Problem The majority of authors agree today that psychosocial factors have more influence on a successful treatment of chronic back pain than other variables, in particular medical findings. Therefore treatments aim to integrate psychotherapeutic intervention in order to lessen emotional impairment, to change behavioral patterns (which advocate rest and the avoidance of physical activity), and to change cognitive attitudes and fears concerning exercise and work ability. Nevertheless, the interplay of cognitive measures and disability in treatment programs still remains an unclear issue. Methods Ninety disabled patients with chronic low back pain were admitted to an 8-week outpatient program of functional restoration and behavioral support. The program consisted of a pre-program (education, stretching and calisthenic exercises) and an intensive treatment period (physical exercises, back school education, cognitive behavioral group therapy, relaxation training, occupational therapy, vocational counseling), which took place for 5 weeks, 7 h a day, as an outpatient program. The targets of the psychological interventions were (a) to change maladaptive behavior (inactivity, social withdrawal) and increase the patient's activity level at home, (b) to alter maladaptive cognitions (somatization, catastrophizing, passive expectations concerning treatment) and to improve their own positive coping skills, (c) to identify and stop operant conditioned behavior, and (d) to prevent depressive symptoms and strengthen the level of emotional control. The program's philosophy encouraged the patients' active efforts to improve their functional status within a therapeutic environment that reinforced positive behavior traits conductive to getting well. The main therapeutic target was to facilitate a return to work. Apart from a medical examination and a personal interview, the patients' physical impairment, pain descriptions, and psychological distress (according to different criteria for evaluation) were also measured. This included variables such as depression, psychovegetative complaints, quality of life and workplace satisfaction, disability, and coping with disease. Measurements were repeated at the end of the 8-week program, and following 6- and 12-month intervals. Results In comparison with the initial values, a statistically significant improvement became evident in reducing pain, disability, depression, and psychovegetative signs (P 〈 0.001). Nearly all results remained stable at the 6- and 12-months examinations. Apart from these results, coping measurements demonstrated little improvement in the three factorial coping dimensions. By use of regression analyses, a differentiated description of psychosocial connections became apparent in three different ways of coping (catastrophizing, searching for information, cognitive control) and parameters of disability. Disability levels corresponded poorly with pain descriptions, physical impairment and coping dimensions. This result indicates that disability should be viewed as a separate component in assessing the patients' description of low back pain. Conclusion An analysis of coping dimensions demonstrated that current cognitive measures might be too general to explain low back disability adequately. In addition, the results indicate that the use of the ’catastrophizing' factor as a separate variable is questionable, since it may simply be a symptom of depression. The relevance of coping as a sensitive parameter for change is also addressed. It is suggested that an alteration in coping strategies may be an important treatment effect, but is subject to individual prerequisites to maximize treatment response. Thus, future research must focus on the complex interactions between personality variables, environmental factors, and the coping demands posed by the specific nature of pain problems. A more lengthy evaluation of so-called ’fear-avoidance beliefs' in combination with ’disability' and coping dimensions could possibly lead to further treatment on the development of chronicity in chronic low back pain patients.
    Notes: Zusammenfassung Problem Die Relevanz psychologischer Variablen in der Behandlung chronischer Rückenschmerzpatienten konnte vielfach demonstriert werden. Dennoch ist bisher noch nicht eindeutig nachgewiesen, inwieweit subjektives Erleben der Patienten und objektiv meßbare Kriterien im Zusammenhang stehen und welche Bedeutung ihnen im Rahmen einer multimodalen Behandlung zukommt. Methode 90 vorwiegend arbeitsunfähige Patienten mit Rückenschmerzen wurden jeweils in Gruppen à 8–10 Patienten jeweils 8 Wochen lang ambulant in einem standardisierten Vorgehen verhaltens- und trainingstherapeutisch behandelt. Neben Aerobic, funktionellem Krafttraining, Herz-Kreislauf-Ausdauer- und Arbeitstraining wurde über 5 Wochen täglich eine 2 stündige kognitiv-behaviorale (Gruppen-)Verhaltenstherapie durchgeführt. Die Ziele des psychotherapeutischen Vorgehens waren eine Veränderung problematischer Verhaltensdispositionen (Inaktivität, Rückzug), maladaptiver Kognitionen (Somatisierung, Katastrophisieren, passives Krankheitsmodell), die Identifikation und der Abbau operanter (Krankheits-)Verstärkung sowie die Bearbeitung emotionaler Beeinträchtigungen (Depression). Vor und nach dem Programm sowie 6 und 12 Monate später wurden diese Patienten im Hinblick auf eine Veränderung sozialer, psychologischer, medizinischer und funktioneller Daten untersucht. Ergebnisse Bis auf die Arbeitszufriedenheit und die dritte Form der Krankheitsbewältigung „kognitive Kontrolle“ kam es über die Meßzeitpunkte bei allen anderen klinisch-psychologischen Variablen jeweils zu signifikanten Verbesserungen, die für die meisten Parameter im Laufe der Katamnesezeit stabil blieben. Anhand von Regressionsanalysen erfolgte eine differenzierte Beschreibung psychologischer Zusammenhänge für das Ausmaß des subjektiven Beeinträchtigungserlebens (Disability, 3 Parameter) und der 3 faktoriellen Formen der Krankheitsbewältigung des FEKB (Rumination, Informationssuche, kognitive Kontrolle). Die Operationslisierungen der ''Disability’ zeigten nur geringfügige statistische Zusammenhänge zu Variablen der Schmerzbeschreibung, zu körperlichen Befunden und zu den erfaßten Formen der Krankheitsbewältigung. Dies ist ein Hinweis darauf, daß sich im „Disability-Erleben“ vorrangig subjektive Patientenbewertungen widerspiegeln. Die Ergebnisse legen in der psychometrischen Diagnostik von Rückenschmerzpatienten eine konzeptuelle Trennung unterschiedlicher Merkmalsbereiche nahe, wobei das „Disability-Erleben“ eine eigenständige Komponente in der Beschreibung darstellt. Schlußfolgerung Die Analyse der Formen der Krankheitsbewältigung machte deutlich, daß es sich hier vermutlich eher um generalisierte Einstellungen zu Krankheit und Gesundheit handelt und nicht um spezifische (und damit veränderbare) Einstellungen bzw. Verhaltensdispositionen in bezug auf Rückenschmerzen. Nach den Ergebnissen der Untersuchung muß bezweifelt werden, ob das generelle Konzept der Krankheitsbewältigung einen relevanten Beitrag zur Identifikation von modulierenden Faktoren bei chronischen (Rücken-) Schmerzen leisten kann. Die in der vorliegenden Operationalisierung gefundenen Formen der Krankheitsbewältigung zeigten eine eher geringe Veränderung über die Zeit und zeichnete sich durch eine „Trait-Charakteristik“ aus. Die Einordnung der Merkmalsbereiche „Disability“ und „Krankheitsbewältigung“ in das sog. „Fear-avoidance-Konzept“ bringt möglicherweise weitergehendere Erkenntnisse über Chronifizierungsbedingungen bei Rückenschmerzen.
    Type of Medium: Electronic Resource
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