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  • 1
    Electronic Resource
    Electronic Resource
    Changes in the T-wave of the electrocardiograph in urticaria (1974)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 90 (1974), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A series of cases is presented, in which non-specific primary changes in the T-waves were observed in electrocardiographs of patients with urticaria, the latter caused by drugs or other substances. In all these patients, no other abnormality was found and they were completely asymptomatic as regards cardiac involvement.A definite ‘cause and effect’ type of relationship was found between the T-wave changes and the urticaria. The mechanism of the T-wave changes remains to be investigated.Since this phenomenon disappears simultaneously with the urticaria, treatment should be determined by the urticaria, and bed rest is not indicated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1974.tb06403.x
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  • 2
    Electronic Resource
    Electronic Resource
    Smoking and Immunity: an Additional Player in the Mosaic of Autoimmunity (1997)
    Oxford, U.K. and Cambridge, USA : Blackwell Publishers
    Scandinavian journal of immunology 45 (1997), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Autoimmune diseases are associated with a variety of predisposing factors. However, the relative contribution of each remains to be established. The purpose of the paper is to focus on cigarette smoking, a common Western habit, as a possible environmental factor for the emergence of autoimmunity. This association is described in view of several recent studies documenting increased susceptibility to autoimmune diseases among smokers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.1997.d01-366.x
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  • 3
    Electronic Resource
    Electronic Resource
    Induction of Tolerance to Experimental Anti-Phospholipid Syndrome (APS) by Syngeneic Bone Marrow Cell Transplantation (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 42 (1995), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Previously, we have shown the ability to induce experimental autoimmune conditions (e. g. SLE, APLS, Wegener's granulomatosis) following active immunization with the pathogenic autoantibody emulsified in adjuvant. The mice first develop anti-autoantibodies (Ab2: anti-id) and eventually generate anti-anti-autoantibodies (Ab3: anti-anti-id) which carry the same antigen binding characteristic as the autoantibody (Ab1), The appearance of the specific autoantibodies in mice sera was associated with the emergence of the compatible laboratory and with the clinical findings characteristic to the respective autoimmune disease. The effects of syngeneic bone marrow transplantation (BMT) on experimental anti-phospholipid syndrome (APS) were investigated. BALB/c mice were immunized with anti-cardiolipin monoclonal antibody (MoAb) named CAM and developed elevated serum titres of anti-phospholipid Abs accompanied by prolonged activated partial thromboplastin time, thrombocytopenia and a high percentage of fetal resorptions. These mice were then lethally irradiated and transfused with bone marrow (BM) cells (T cell depleted) from syngeneic naive mice. The titres of antiphospholipid antibodies were reduced in the recipients. The decrease in titre of autoantibodies was found to be related to depletion of antibody forming cells in vivo, associated with reduced proliferative response of lymph node cells to anti-cardiolipin MoAbs. The recipients showed improvement in clinical parameters following syngeneic BMT. The same recipients developed specific unresponsiveness to a second challenge with the anticardiolipin MoAb (CAM), but developed experimental systemic lupus erythe-matosus upon immunization with a monoclonal anti-DNA antibody. We conclude that acute myeloablative immunosuppression combined with syngeneic bone marrow transplantation may induce a state of tolerance to the pathogenic autoantibodies in mice with experimental APLS. Our results suggest that a similar approach may be useful in treating life-threatening autoimmune syndromes (e. g. catastrophic APLS) in clinical practice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1995.tb03649.x
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  • 4
    Electronic Resource
    Electronic Resource
    Leucocytoclastic vasculitis after coronary bypass artery grafting (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 135 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.d01-1122.x
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of aging on the induction of experimental systemic lupus erythematosus (SLE) in mice
    Amsterdam : Elsevier
    Mechanisms of Ageing and Development 58 (1991), S. 233-244 
    Details
    ISSN: 0047-6374
    Keywords: Aging ; Autoantibodies ; Idiotypic network ; Systemic lupus erythematosus (SLE)
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0047-6374(91)90095-H
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  • 6
    Electronic Resource
    Electronic Resource
    The Importance of the Pathogenic 16/6 Idiotype in the Induction of SLE in Naive Mice (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 31 (1990), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have previously demonstrated the pathogenicity of the common anti-DNA idiotype designated 16/6 Id. Immunization of naive mice with the 16/6 Id induced SLE-like disease characterized by serological (e.g. anti-dsDNA and anti-Sm auto-antibodies), clinical (increased ESR, leucopenia and proteinuria), and pathological (16/6 Id deposition in kidneys) parameters. To elucidate further the role of the 16/6 Id in SLE induction the following studies were carried out: BALB/c mice were immunized with SA-1, a human anti-DNA monoclonal antibody carrying the 16/6 Id; TB-68, a mouse monoclonal anti-tuberculosis (TB) glycolipid, which binds dsDNA and carries the 16/6 Id; TB-72, a mouse monoclonal anti-TB glycolipid that binds DNA and does not harbour the 16/6 Id; and 4B4, a human anti-Sm antibody that carries the 16/6 Id. SLE was induced in BALB/c mice only when immunized with SA-l, TB-68, and 4B4, namely antibodies with diverse binding capacities albeit having the 16/6 Id. Our studies further support previous evidence on the pathogenic role attributed to the 16/6 Id in SLE, and suggest that SLE is most probably an idiotype-induced disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1990.tb02741.x
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  • 7
    Electronic Resource
    Electronic Resource
    Pathogenic anti-DNA idiotype (16/6 Id) in systemic lupus erythematosus (1991)
    Springer
    Rheumatology international 11 (1991), S. 91-93 
    Details
    ISSN: 1437-160X
    Keywords: Systemic lupus erythematosus ; Anti-DNA antibodies ; Experimental diseases ; Autoantibodies ; Idiotipes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Systemic lupus erythematosus (SLE) is regarded as a classical autoimmune disease. Despite this belief, no one has been able to induce the disease in naive animals, neither with DNA nor with anti-DNA antibodies. We report on the induction of SLE in BALB/c mice following immunization with a pathogenic anti-DNA idiotype (16/6 Id) or its anti-Id. We also report on a specific treatment with T suppressor cells specific for the 16/6 Id. The induction of SLE in naive mice with a pathogenic anti-DNA Id suggests an additional mechanism for the diversity of manifestations in this disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304494
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  • 8
    Electronic Resource
    Electronic Resource
    Antiperinuclear factor – clinical, serological and genetic correlates in Israeli patients with rheumatoid arthritis (1997)
    Springer
    Rheumatology international 17 (1997), S. 141-143 
    Details
    ISSN: 1437-160X
    Keywords: Key words Rheumatoid arthritis ; Antiperinuclear factor ; HLA-DR4/DR1
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The possible association between the presence of antiperinuclear factor (APF) and clinical and genetic parameters was investigated in 54 Israeli patients with rheumatoid arthritis (RA). Rheumatoid factor (RF) was detected in the sera of 43 patients (80%) and APF was positive in 33 (61%). No significant statistical differences were found in the presence of HLA-DR4 and/or DR1 between APF-positive and -negative patients. Furthermore, neither the Ritchie articular index nor the patient's functional class correlated with the presence of APF. The results of our study suggested that although Israeli patients have a different genetic background, the presence and behaviour of APF is similar to that of other Caucasian populations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002960050025
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  • 9
    Electronic Resource
    Electronic Resource
    Intravenous immunoglobulin therapy in a patient with lupus serositis and nephritis (2000)
    Springer
    Rheumatology international 19 (2000), S. 199-201 
    Details
    ISSN: 1437-160X
    Keywords: Key words Intravenous immunoglobulin ; Pericarditis ; Pleural effusion ; Proteinuria ; Systemic lupus erythematosus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The use of intravenous immunoglobulin (IVIg) has been reported as an immunomodulating agent in several autoimmune diseases, including systemic lupus erythematosus (SLE). Herein we report a SLE patient with severe clinical presentation that included pericarditis, pleural effusion, nephrotic range proteinuria, leukopenia, and lymphopenia. The patient received one course of high-dose IVIg (2.8 g/kg body weight), and within a week of post-IVIg therapy, her condition significantly improved. One-month post-IVIg there were decreased proteinuria, elevated leukocytes and lymphocytes count, decrease in antinuclear and anti-dsDNA antibodies, and disappearance of pericarditis and pleuritis. This case demonstrates the efficacy of IVIg in severe SLE with various clinical manifestations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002960000053
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  • 10
    Electronic Resource
    Electronic Resource
    Description and forecast of summer climate in physiologically significant terms (1978)
    Springer
    International journal of biometeorology 22 (1978), S. 75-81 
    Details
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract The Discomfort Index (DI) was found to be an accurate expression of the atmospheric evaporative (cooling) power, and hence the heat load. It conveys the relevant climatic conditions in summer in physiologically significant terms. From 22–24 units a slight heat load exists, from 24.1–28 the heat load is moderate and above 28.1 a severe heat load exists. The heat load during the month of August was analyzed for 2 towns in Israel: Tel-Aviv (in the coastal plain) and Beer-Sheba (in the northern part of the desert). On the basis of this example a method is suggested to express summer climate as daily hours of heat load. Information about heat stress can be conveyed in terms which are sïgnificant physiologically and meaningful to the public.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01552886
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