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Use of immune lymphocytes to detect expression of herpetic genome (1974)

SPRECHER-GOLDBERGER, SUZANNE ; THIRY, LISE ; VANDENBUSSCHE, PAUL

[s.l.] : Nature Publishing Group

Nature 250 (1974), S. 678-679

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] We have tried to transfer the nucleic acids of a transformed cell line to normal cells, and to check whether functional viral nucleic acid had been transferred, by assaying the recipient cells for herpetic antigen. For the assay, we used immune lymphocytes since we found that the donor transformed ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/250678a0

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Mason-Pfizer like virus in kidney grafted patients (1979)

Thiry, Lise ; Sprecher-Goldberger, Suzanne ; Vandenbussche, Paul ; [et al.]

Springer

Medical microbiology and immunology 165 (1979), S. 255-269

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ISSN: 1432-1831

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Lymphocytes from a kidney grafted patient were specifically stimulated to incorporate thymidine in vitro by mitomycin C treated Hela cells infected with a Mason-Pfizer like virus (MPV). The thermolabile mutant of vesicular stomatitis virus (VSV tl) grown in leukocytes of this patient produced pseudotypes which were neutralized by the patient's sera and by rabbit anti-MPV sera. Coculture of the patients leukocytes with SIRC cells yielded virus populations with dual properties; those of MPV plus those of another virus which was not typed serologically but possessed the biological properties of typical C particles. The patient also had neutralizing antibodies to MPV, which were detected by inhibition of syncytium formation on KC cells and by neutralization of VSV tl (MPV) pseudotypes. Preliminary results on the frequency of similar findings in other kidney grafted patients are presented.