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  • 1
    Electronic Resource
    Electronic Resource
    Cycloechinulin, a Trp-Ala-derived alkaloid from the fungus Aspergillus ochraceus (2001)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 57 (2001), S. o909-o912 
    Details
    ISSN: 1600-5368
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The structure of the Trp–Ala-derived, non-basic alkaloid cycloechinulin from the mycelial mat of the fungus Aspergillus ochraceus is described; systematic name: (3S)-2,3,8,9-tetrahydro-11-methoxy-3,8,8-trimethylpyrazino[1′,2′:1,2]azocino[5,4-b]indole-1,4-dione–methanol (4/1), C20H21N3O3·0.25CH4O. There are four independent molecules plus one methanol molecule in the asymmetric unit. The conformations of molecules 1–3 are almost identical, while molecule 4 shows a different conformation in the fused 8–6 ring moiety.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S1600536801014234
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A new hydrocarbon degradation fungus: Verticillium ecanii (1980)
    Springer
    Applied microbiology and biotechnology 10 (1980), S. 259-260 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Verticillium lecanii was isolated from tar lumps resulting from a marine oil spill. It has not previously been reported to utilize hydrocarbons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00508613
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Citrinin, ochratoxin A and iron. Possible implications for their biological function and induction of nephropathy (1996)
    Springer
    Mycopathologia 134 (1996), S. 103-107 
    Details
    ISSN: 1573-0832
    Keywords: citrinin ; desferal ; iron ; Neisseria meningitidis ; nephropathy ; ochratoxin A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Experiments with Neisseria meningitidis have shown that Fe3+ to some extent can reverse the toxicity of ochratoxin A and citrinin, as measured by inhibition zones around impregnated paper discs. Similar phenomena were observed with the less toxic ochratoxin B. Zearalenone also inhibited growth, but its effect was not counteracted by iron. The mycotoxins aflatoxin B1 and deoxynivalenol did not inhibit bacterial growth at all. Desferal (deferoxamine) also inhibited growth of meningococci, but iron totally abolished this inhibition. The results indicate that ochratoxin A and citrinin interfere with iron metabolism in this organism but that other additional toxic mechanisms are involved as well since a marked growth inhibition by both toxins was also observed in the presence of iron. One function of ochratoxin A and citrinin in nature could consequently be to affect the iron uptake of other competing microorgansms. Since both toxins interfere with iron and both cause nephropathy, a possible connection between these properties and lipid peroxidation is also briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00436872
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  • 4
    Electronic Resource
    Electronic Resource
    Mechanism of ochratoxin A-induced immunosuppression (1989)
    Springer
    Mycopathologia 107 (1989), S. 153-159 
    Details
    ISSN: 1573-0832
    Keywords: immunosuppression ; lymphocyte activation ; ochratoxins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Ochratoxin A (OA) has been reported to affect immune function both at the level of antibody synthesis and natural killer (NK) cell activity. In the present study we demonstrate that exposure of purified human lymphocyte populations and subpopulations to the toxin will abrogate the cells' ability to respond to activating stimuliin vitro. Thus, both IL-2 production and IL-2 receptor expression of activated T lymphocytes are severely impaired. When the cells are preincubated with the analogue ochratoxin B (OB) prior to OA exposure, the inhibitory effect of OA is reversed. Furthermore, the inhibitory effect of OA on antibody production is not only due to blocking of T helper cell function. Highly purified B lymphocytes will not respond to polyclonal activatorsin vitro after a brief pulse with OA. The results strongly suggest that the toxin causes its immunosuppression through interference with essential processes in cell metabolism irrespective of lymphocyte population or subpopulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00707553
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    Paper (German National Licenses)
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