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  • 1
    Electronic Resource
    Electronic Resource
    Long-term treatment of gastro-oesophageal reflux disease patients with frequent symptomatic relapses using rabeprazole: on-demand treatment compared with continuous treatment (2005)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : On-demand treatment may be an alternative in the long-term treatment of non-severe gastro-oesophageal reflux disease in patients with frequent symptomatic relapses.Aim : To compare the efficacy of on-demand treatment with rabeprazole 10 mg versus continuous treatment in the long-term treatment of patients with frequent symptomatic relapses of mild to moderate gastro-oesophageal reflux disease.Methods : This randomized, open-label study enrolled patients diagnosed with non-erosive reflux disease or oesophagitis grade 1 or 2 (Savary–Miller classification) reporting frequent symptomatic relapses (requiring ≥2 courses of antisecretory therapy during the previous year), whose intensity is rated at least moderate (〉2 on a 5-point Likert scale). After a 4-week selection phase with rabeprazole 10 mg once daily, patients reporting symptom relief (Likert score ≤2) were randomized to receive either rabeprazole 10 mg continuous treatment or on-demand treatment for 6 months. The main evaluation criterion was the rate of symptom relief (scored on the Likert scale) after 6 months.Results : One hundred and seventy-six patients were enrolled in the 4-week selection phase (men, 53%; mean age, 49 years; non-erosive reflux disease, 36.4%; gastro-oesophageal reflux disease 1, 53.4%; gastro-oesophageal reflux disease 2, 10.2%). Rabeprazole relieved symptoms in 88.6% of patients. Of this group, 152 were randomized to the comparative phase to receive rabeprazole 10 mg continuous treatment (once daily) or on-demand treatment (continuous treatment, n = 81; on-demand treatment, n = 71). At month 6 (end point), the symptom relief rate was slightly higher for patients in the continuous treatment group compared with those in the on-demand treatment group: 86.4% versus 74.6%, respectively. This difference was not statistically significant (P = 0.065). For the overall quality of life score, there was no difference between the continuous treatment and on-demand treatment groups (86.25 and 84.94). Mean daily consumption of rabeprazole was significantly lower in the on-demand treatment group versus the continuous treatment group (0.31 tablets versus 0.96 tablets; P 〈 0.0001).Conclusion : On-demand therapy with rabeprazole 10 mg provides an alternative to continuous therapy in patients with mild to moderate gastro-oesophageal reflux disease suffering from frequent symptomatic relapses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02413.x
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  • 2
    Electronic Resource
    Electronic Resource
    Meiotic chromosome behaviour in an allotriploid derived from an amphidiploid × diploid mating in Cucumis (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 124 (2005), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: A synthetic amphidiploid species Cucumis hyriviis Chen & Kirkbride (2n = 4x = 38; genome designated as HHCC) has recently been created from an interspecific mating between C. sativus L. (2n = 2x = 14: genome designated as CC) and C. hystrx. Chakr. (2n = 2x = 24; genome designated as HH). This amphidiploid is resistant to root knot nematode, tolerant to low irradiance, and has higher nutritional value than standard processing cucumber cultivars. An allotriploid (2n = 3x = 26; HCC) was derived from a cross between C. sativus L. and C. hytivus Chen & Kirkbride. Diploid meiotic behaviour in C. sativus and C. hystrix involves the development of seven and 12 metaphase bivalents respectively. In the derived allotriploid. univalents. bivalents, and trivalents (at relatively low frequency) were observed at metaphase I indicating that some homeologues from the C and H genomes can synapse. Based on a comparative karyotype analysis of cucumber (i.e. chromosome size and pairing behaviour) and aliotriploid plants, the seven bivalents observed at metaphase I were ascertained to be cucumber homologues, while the 12 univalents were of C. hystrix origin thus confirming the allotriploid karyotypic constitution to be HCC. On average, the frequency of trivalents was 0.24 at diakinesis and 0.22 in 100 meiocytes at metaphase I. indicating the possibility of genetic exchange due to the homoeology between the C and H genomes. After simultaneous cytokinesis, only polyads were observed in pollen mother cells (PMCs) at telophase II, which led to the production of sterile pollen grains. Multi-polarization of chromosomes was dominant at anaphase II. However. in about 20% PMCs. chromosomes separated to form a 7C + 1-2H complement, suggesting a possible method for the production of alien addition cucumber-C hystrix lines through further backcrossing of the allotriploid to diploid cucumber.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0523.2005.01066.x
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  • 3
    Electronic Resource
    Electronic Resource
    Conformity and genetic relatedness estimation in crop species having a narrow genetic base: the case of cucumber (Cucumis sativus L.) (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 124 (2005), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: A set of 155 SSR (107) and SCAR (48) markers were used to evaluate 53 cucumber (Cucumis sativus L.) accessions of diverse origin to characterize genetic relationships and to define a standard marker array that was most effective in detecting genetic differences in this germplasm array. A multivariate marker-based analysis of diverse germplasm using this standard marker array (17 SSR and 5 SCAR markers) was compared with results from a set of 70 previously reported RAPD markers, and then used to explore the potential value of these genetic markers for plant variety protection (PVP) and the establishment of essential derivation (ED) threshold values in this species using elite lines and hybrids and backcross progeny. Diversity analysis allowed identification of distinctly different lines that were used for the construction of three sets of backcross families (BC1-BC3). While general genetic relationships among accessions were similar in SSR/SCAR analyses (rs= 0.65) using two genetic distance (GD) estimators, differences in accession relationships were detected between RAPD and SSR/SCAR marker evaluations regardless of the estimator used. The GDs among elite germplasm with known pedigrees were relatively small (0.06-0.23 for any pairwise comparison). GD values decreased and degree of fixation (at three to seven loci depending on the mating) increased with increased backcrossing such that recurrent parent allelic fixation occurred in least one family of each of the BC3 families. In many instances the degree of fixation of loci was not uniformly achieved in the BC3. Although the level of genetic polymorphisms will likely restrict the use of molecular markers for PVP and the establishment of ED values, the use of single nucleotide differences will likely provide opportunities to define specific functional distances that have potential for PVP in cucumber. Nevertheless, without an expanded, genetically robust standard marker array (e.g. 50 codominant markers), ED threshold values will be difficult to define in this species, and perhaps will require the appraisal of single nucleotide polymorphisms as discriminators of difference in this species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0523.2004.01061.x
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  • 4
    Electronic Resource
    Electronic Resource
    Assessment of genetic relationships among Cucumis spp. by SSR and RAPD marker analysis (2004)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 123 (2004), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The first successful production of a sterile interspecific hybrid obtained from a cross between Cucumis hystrix Chakr. (2n = 2x = 24) and Cucumis sativus var. sativus L. (2n =2x = 14), and its subsequent fertility restoration through chromosome doubling provide an effective means for investigating genetic relationships among Cucumis spp. In this study, random amplified polymorphic DNA (RAPD) and simple sequence repeat (SSR) markers were used to investigate relationships among C. s. var. sativus L., C. s. var. hardwickii (R.) Alef., C hystrix, C. hytivus Chen & Kirkbride (the amphidiploid species from chromosome doubling of the C. sativus x C. hystrix interspecific hybrid, 2n = 38), C. melo (2n =2x = 24) and C. metuliferus Meyer and Naudin (2n =2x= 24). A total of 109 SSR bands and 398 RAPD primed sites were used to calculate Jaccard's distance coefficients for cluster analysis using a unweighted pair-group method using an arithmetic averaging (UPGMA) algorithm. The genetic relationships identified using SSR and RAPDmarkers were highly concordant, such that the correlation between SSR and RAPDgenetic distance (GD) estimates was r = 0.94. SSR and RAPDanalysis of 22 accessions allowed for their grouping into two distinct groups designated as CS and CM. While group CS consisted of 11 C. sativus genotypes, and the C. hytivus and C. hystrix accessions, group CM included six C. melo genotypes and C. metuliferus. The GD values between C. hystrix and C. sativus ascribed by SSR and RAPD matrices were 0.59 and 0.57, respectively. These GDs were smaller than those detected between C. hystrix and C melo (0.87 and 0.70 derived from SSR and RAPD markers, respectively).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1439-0523.2003.00889.x
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  • 5
    Electronic Resource
    Electronic Resource
    Inhibition of mouse testicular DNA synthesis by mutagens and carcinogens as a potential simple mammalian assay for mutagenesis
    Amsterdam : Elsevier
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 37 (1976), S. 67-76 
    Details
    ISSN: 0027-5107
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0027-5107(76)90055-5
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  • 6
    Electronic Resource
    Electronic Resource
    Relative mutagenic potencies determined in the micronucleus test
    Amsterdam : Elsevier
    Journal of Theoretical Biology 73 (1978), S. 575-584 
    Details
    ISSN: 0022-5193
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0022-5193(78)90123-6
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  • 7
    Electronic Resource
    Electronic Resource
    Induction of micronuclei in mouse and hamster bone-marrow by chemical carcinogens
    Amsterdam : Elsevier
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 43 (1977), S. 255-261 
    Details
    ISSN: 0027-5107
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0027-5107(77)90009-4
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  • 8
    Electronic Resource
    Electronic Resource
    Surgical aspects of thyroid autonomy in multinodular goiter (1983)
    Springer
    World journal of surgery 7 (1983), S. 363-371 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'étude consécutive de 217 malades atteints de goitre multinodulaire et traités chirurgicalement a permis de constater que 43% d'entre eux présentaient une secrétion hormonale thyroÏdiennes autonome significative ainsi que l'a montré l'absence de réponse après TRH (TSH〈1,0 4 ΜU/ml après injection intra-veineuse (200 mg) ou ingestion (40 mg) s'accompagnant de valeurs normales de l'index FT-4 et de l'index FT-3 (hyperthyroÏdisme préclinique) dans 74% des cas et d'hyperthyroÏdisme dans 26% des cas. Le taux de la secrétion hormonale thyroÏdienne autonome augmentait parallèlement avec le poids du goÎtre et l'âge des malades. La récidive du goÎtre peut Être non seulement TSH dépendante mais elle peut aussi se développer de faÇon autonome à partir du tissu normal laissé en place. Ceci implique la résection sélective du goitre nodulaire au lieu de la résection subtotale uniforme laissant en place des résidus au niveau du hile. Les résultats de la tactique opératoire et de la technique qui furent adoptées en fonction de ces critères sont présentés 1)—la morbidité opératoire fut basse; 2)—chez les malades ne répondant pas au TRH la secrétion hormonale thyroÏdienne autonome fut basse après résection; 3)—aucune hypothyroÏdie ne fut constatée mais une élévation légère de la sécrétion de TSH fut observée chez 40% des opérés; 4)—la surveillance de 76 opérés sélectionnés pendant une période de 3,5 ans révéla la survenue d'une dépendance TSH et d'une récidive autonome se développant au niveau du lobe laissé en place. La résection sélective du goitre est conseillée sur la base de nouvelles conceptions physiopathologiques s'appliquant au goitre multinodulaire bénin et de l'amélioration de la technique de la chirurgie thyroÏdienne.
    Abstract: Abstracto En un estudio prospectivo de 217 pacientes consecutivos con bocio multinodular seleccionados para tratamiento quirÚrgico, 43% presentaron significativa secretion autónoma de hormona tiroidea a juzgar por falta de respuesta a TRH (TSH〈1.0 ΜU/ml después de TRH intravenosa−200 Μg, u oral −40 mg-) con valores normales de índice FT4 e índice FT3 (hipertiroidismo preclínico) en el 47%, y con hipertiroidismo en el 26% de estos casos. La magnitud de secreción autónoma de hormona tiroidea se encontró aumentada en relación al peso promedio del bocio y a la edad de los pacientes. El crecimiento nodular del bocio es considerado como manifestación adicional de escape de la dependencia de TSH, especialmente respecto a la replicación celular del epitelio folicular. La recurrencia del bocio puede no ser, por consiguiente, TSH-dependiente, sino que también puede evolucionar a partir de tejido bocioso residual de crecimiento autónomo. Esto implica una resección selectiva del bocio nodular en vez de la resección subtotal uniforme que deja remanentes en el hilio. Se presentan los resultados prospectivos de esta táctica y técnica operatoria: 1) la morbilidad operatoria fue baja; 2) en pacientes que no respondían a TRH la secreción autónoma de hormona tiroidea postablación fue usualmente baja. La función tiroidea inducida por TRH y TSH apareció recuperada en 2 a 4 meses; 3) no ocurrió hipotiroidismo, pero se presentó una secreción ligeramente elevada de TSH en 40% de los pacientes; 4) el seguimiento de 76 pacientes seleccionados durante un promedio de 3.5 años reveló la ocurrencia de recurrencias TSH-dependientes y recurrencias autónomas en lóbulos no resecados. La resección selectiva es preconizada sobre la base de nuevos conceptos patofisiológicos en el bocio benigno multinodular y sobre la base del refinamiento de la técnica de cirugía tiroidea.
    Notes: Abstract In a prospective study of 217 consecutive patients with multinodular goiter selected for surgical treatment, 43% had significant autonomous thyroid hormone secretion as evidenced by TRH unresponsiveness [TSH〈1.0 ΜU/ml after intravenous (200 Μg) or oral (40 mg) TRH], with normal values of the FT4-Index and FT3-Index (preclinical hyperthyroidism) in 74%, and with hyperthyroidism in 26% of these cases. The amount of autonomous thyroid hormone secretion increased with the mean goiter weight and age of patients. Nodular goiter growth is considered a further manifestation of escape from normal TSH dependence, namely, with respect to follicular epithelium cell replication. Goiter recurrence may, therefore, not only be TSH dependent, but it may also evolve from autonomously growing goiter tissue left behind. This implies a selective nodular goiter resection instead of the uniform subtotal resection leaving remnants at the hilus. Prospective results of this operative tactic and technique are presented: (a) operative morbidity was low; (b) in TRH-unresponsive patients, the postablative autonomous thyroid hormone secretion was usually low. The thyrotropic and TSH-mediated thyroid function recovered within 2–4 months; (c) no hypothyroidism occurred, but slightly elevated TSH secretion resulted in 40% of the patients; and (d) follow-up of 76 selected patients during a mean of 3.5 years revealed the occurrence of TSH-dependent and of autonomous recurrences, developing in nonresected lobes. Selective goiter resection is advocated on the basis of newer pathophysiological concepts in benign multinodular goiter and on the basis of refinement of the thyroid surgical technique.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01658085
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  • 9
    Electronic Resource
    Electronic Resource
    Genetic diversity in Cucumis sativus L. assessed by variation at 18 allozyme coding loci (1989)
    Springer
    Theoretical and applied genetics 78 (1989), S. 119-128 
    Details
    ISSN: 1432-2242
    Keywords: Biochemical loci ; Cucumber ; Isozymes ; Multivariate analysis ; Starch-gel electrophoresis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The genetic diversity of the U.S. Cucumis sativus L. germplasm collection [757 plant introductions (PI) representing 45 countries] was assessed using 40 enzymes which represented 74 biochemical loci. Polymorphisms were observed at 18 loci (G2dh-1, Gpi-1, Gpi-2, Gr-1, Gr-2, Idh, Mdh-1, Mdh-2, Mdh-3, Mpi-2, Pepla-2, Peppap-2, Per-4, Pgd-1, Pgd-2, Pgm-1, Pgm-3, and Skdh). Two PIs (285606 and 215589) contained alleles [G2dh-1(1) and Per-4(2), respectively] which did not occur in any other PI. Other alleles which occurred in low frequencies (in 〈 1% of the PIs) included Gpi-1(3), Gpi-2(3), Gr-1(3), Gr-2(1), Idh(1), Mdh-1(2), Mdh-2(1), Peppap-2(1), and Pgd-1(1). Individual loci containing more than one allele in greater than 20% of the PIs included Mpi-2, Pepla-2, Pgd-2, and Pgm-1. Multivariate analyses aided in the reduction of data (principle components), depicted relationships among PIs (cluster), and identified the most discriminating enzyme loci (Pgm-1, Pepla-2, Gr-1, Pgd-2, Mpi-2, and Skdh) (classification and regression tree).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00299764
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  • 10
    Electronic Resource
    Electronic Resource
    Inheritance and linkage relationships of isozyme and morphological loci in cucumber (Cucumis sativus L.) (1996)
    Springer
    Theoretical and applied genetics 92 (1996), S. 865-872 
    Details
    ISSN: 1432-2242
    Keywords: Isozymes ; Genetic markers ; Disease resistance ; Genetic map
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Twenty-one polymorphic and 17 monomorphic cucumber (Cucumis sativus L.) isozyme loci were identified in 15 enzyme systems. Seven of the polymorphic loci (Ak-2, Ak-3, Fdp-1, Fdp-2, Mpi-1, Pep-gl, and Skdh) had not been described previously. Segregation in F2 and BC families for isozyme and morphological loci demonstrated agreement with the expected 1∶2∶1 and 1∶1 segregation ratio (P〈0.01). Nine morphological markers were found to be linked to isozyme loci and were integrated to form a map containing four linkage groups spanning 584 cM with a mean linkage distance of approximately 19 cM. Linkage groups (A to D) contain the following loci in genetic order: A psl, Pep-la, B, Per, dm, Pgm, Mpi-1, Idh, Ar, Fdp-1, Ak-2, Pgd-1, Mpi-2 and gl; B lh, Mdh-2, Pep-gl, Pgd-2, Fdp-2, Ccu, Mdh-3, Ak-3, ll, de, F and Mdh-1, and Gr; C cor, Gpi, and Skdh; D Tu and ss. This study detected four new linkages between morphological markers (dm-psl, de-ll, ll-F, and de-F) and confirmed previously reported linkages, dm-Ar and Tu-ss. The isozyme/morphological map constructed in this study led to a more comprehensive understanding of the genetic relationships between several economically important traits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221899
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