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  • 1
    Electronic Resource
    Electronic Resource
    ASSOCIATION OF GOITROUS AUTOIMMUNE THYROIDITIS WITH HLA-DR3 IN EASTERN HUNGARY (1987)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 14 (1987), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: An association of HLA-DR5 and goitrous autoimmune thyroiditis has been reported elsewhere (Farid et al., 1981; Weissel et al., 1980). Recently, the disease was found to be associated with HLA-DR4 in Newfoundlanders (Farid & Thompson, 1986). In order to find out whether different HLA associations with the disease may be found in different ethnic groups, we have now typed 68 patients with autoimmune goitrous thyroiditis from Eastern Hungary for HLA-A, -B, -C, and -DR antigens; 66 of these patients were also typed for IgG heavy-chain markers (Gm). A significant increase in DR3 (OR = 3·30) and a non-significant increase in DR4 (OR = 1·67) were found in the patients when compared with controls. The Gm3 allele, g, interacted with DR3 to enhance the risk for goitrous autoimmune thyroiditis. Hashimoto's disease may show different associations in different ethnic groups, and indeed within the same ethnic group, when newly diagnosed patients are typed several years apart.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1987.tb00374.x
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  • 2
    Electronic Resource
    Electronic Resource
    INTERPLAY OF IMMUNOGLOBULIN G HEAVY CHAIN MARKERS (Gm) AND HLA IN PREDISPOSING TO SYSTEMIC LUPUS NEPHRITIS (1986)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 13 (1986), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: We have studied the distribution of IgG heavy chain markers (Gm) among 90 Hungarian patients with systemic lupus erythematosus (SLE) (55 of whom were also typed for HLA). This study confirms previously described increases in HLA-B8 and DR3 in this condition. No difference in the distribution of Gm phenotypes was found between patients and 168 controls from the same geographical area. HLA-B8/Gm homozygous individuals were, however, at greater risk for SLE (relative risk = 5.13) compared to B8+Gm heterozygotes or B8− individuals, irrespective of Gm phenotype. When patients with renal manifestation (n= 40) were compared to those without, the Gm phenotype 3; 5, 13 was found to be significantly increased (x2= 10.36, P 〈 0.0001, relative risk (RR) = 4.69). HLA and Gm increased additively the risk for renal manifestations in that for those patients who were both Gm3;5,13+ and HLA-B8+, PR was 110, while it was 21.2 for Gm3;5, 13−/B8+, 7.9 for Gm3;5, 13+/B8− and 1.0 for Gm3;5, 13−/B8− patients. The study suggests that combined HLA and Gm typing can be used to identify SLE patients at high risk for manifesting renal abnormalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1986.tb01078.x
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  • 3
    Electronic Resource
    Electronic Resource
    HETEROGENEITY OF SYSTEMIC LUPUS ERYTHEMATOSUS ELUCIDATED BY CLUSTER ANALYSIS (1986)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 13 (1986), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: For 75 patients with systemic lupus erythematosus (SLE), 39 laboratory and clinical characteristics, including HLA-A, B, C and DR typing, were analysed using a cluster analysis technique. Three groups were identified. Group I (46 patients) was characterized by infrequently severe disease, good response to therapy and infrequent multisystem involvement. Group I1 (24 patients) was characterized by a severe course of disease (although the tendency to remit after therapy was not unusual), and, frequently, renal involvement and pericarditis. Group 111 (5 patients) was characterized by more severe renal disease. Of the 75 patients studied, 38.7% possessed HLA-DR3, compared to 17.4% of controls. Group I patients did not differ from controls but 80% of Group II patients and 4/5 Group III patients had DR3. Cluster analysis identifies subsets of SLE patients who show marked differences in disease course and severity, correlated with possession of the HLA B8, DR3 phenotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1986.tb01117.x
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  • 4
    Electronic Resource
    Electronic Resource
    Clinical and family studies in Hungarian patients with gout (1992)
    Springer
    Rheumatology international 12 (1992), S. 165-168 
    Details
    ISSN: 1437-160X
    Keywords: Gout ; Hyperuricaemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this study we examined 22 Hungarian male probands with gout and 105 of their first degree relatives. This was the first family study in Hungary in which the characteristics of distribution of gout and hyperuricaemia among patients with gout and their first degree relatives, as well as the possible correlation between the prevalence of the disease and MHC class I antigens was investigated. Our gout patients showed the following characteristics: (1) There was a typical onset after age 40, benign oligoarticular form of arthritis, underexcretion of uric acid, moderate hypertension without evidence of reduced renal function, and a relatively high frequency of hyperostosis. (2) The prevalence of hyperuricaemia and gout exceeded the general population level in the first degree relatives of our gout patients. (3) The distribution of MHC class I antigens among the first degree relatives of our patients with gout showed no characteristic patterns. (4) There was no correlation between HLA B27 antigens and prevalence of gout or hypeostosis in family sibling studies. (5) The high frequency of gout and hyperuricaemia, as well as the lack of characteristic HLA patterns among the first degree relatives of gout patients in our family studies, point to the possible cumulative effect of several genes and environmental factors in the etiopathogenesis of this disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00302147
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  • 5
    Electronic Resource
    Electronic Resource
    Cytogenetic analyses of three papillary carcinomas and a follicular adenoma of the thyroid
    Amsterdam : Elsevier
    Cancer Genetics and Cytogenetics 44 (1990), S. 119-129 
    Details
    ISSN: 0165-4608
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-4608(90)90204-N
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  • 6
    Electronic Resource
    Electronic Resource
    Lymphocytotoxic antibodies in lightdermatoses (1977)
    Springer
    Archives of dermatological research 260 (1977), S. 71-75 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das Vorkommen von lymphocytotoxischen Antikörpern vom “kalten Typ” wurde bei 92 Patienten mit verschiedenen Photodermatosen untersucht. Während solche Antikörper im Sera der Patienten mit cutaner Porphyrie in 39% der Fälle nachgewiesen werden konnten, wurden diese bei Patienten mit polymorpher Lichtdermatose in keinem Falle gefunden. Es konnte gezeigt werden, daß das Auftreten lymphocytotoxischer Antikörper, die Dauer des Bestehens der Porphyrie und der Schweregrad der Leberschädigung miteinander korrelierten. Die Befunde weisen auf eine langfristige Gewebeschädigung bei der Entstehung dieser Antikörper hin. Die Ergebnisse stehen im Einklang mit der Auffassung, daß die polymorphe Lichtdermatose nicht zur Gruppe des Lupus erythematodes gehört.
    Notes: Summary Occurrence of lymphocytotoxic antibodies of the “cold-type” was studied in 92 cases with various lightdermatoses. They were detected in the sera of 39% of the patients with cutaneous porphyrias and never in cases with polymorphous light eruption and other photodermatosis. Correlations between their presence and the duration of the porphyria as well as the severity of hepatopathy could be observed. The results indicate the importance of a long-standing tissue damage in the production of these antibodies. In addition the findings confirm the hypothesis according to which polymorphous light eruption does not belong to the lupus erythematosus entity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558017
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  • 7
    Electronic Resource
    Electronic Resource
    Familial leukemia: Ph1 positive acute lymphoid leukemia of a mother and her infant (1981)
    Springer
    Annals of hematology 43 (1981), S. 265-272 
    Details
    ISSN: 1432-0584
    Keywords: Acute lymphoid leukemia ; Ph1 positivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors report the case of a mother and her infant who both suffered from acute lymphoid leukemia (ALL). Both leukemic processes proved to be Ph1 positive and of “0” cell character. In addition to the clinical and hematological findings the results of HLA antigen determination and cytogenetic studies are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320456
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  • 8
    Electronic Resource
    Electronic Resource
    Immunological investigations on patients with transplanted cornea (1975)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 196 (1975), S. 181-185 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach kurzer Beschreibung der Begriffe der HL-A Antigene und der Histokompatibilität besprechen die Autoren retrospektive Untersuchungen in Verbindung mit der Keratoplastik. Sie stellen fest, daß Transplantationen zwischen identischen Gruppen des ABO-Systems eine größere Wahrscheinlichkeit haben, mit Erfolg zu enden, falls mindestens 2 HL-A Antigene des Spenders und des Empfängers identisch sind; ein Umstand, der besonders dann wichtig ist, wenn die Überpflanzung in ungünstige, vaskularisierte Umgebung erfolgt.
    Notes: Summary After briefly describing the conceptions of the HL-A antigens and of histocompatibility, the authors give an account of their own retrospective examinations in connection with keratoplasty. Transplantations between identical groups of the ABO-system have a greater probability of ending successfully, if at least 2 HL-A antigens of donor and recipient are identical; this being chiefly important when grafting is carried out into unfavourable, vascularized surroundings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414804
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