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  • 1
    Electronic Resource
    Electronic Resource
    A lead-on-sapphire superconducting cavity of superior quality (1986)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 59 (1986), S. 854-858 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A cavity consisting of a superconducting lead film on a sapphire substrate has been fabricated to obtain the enhanced frequency stability possible with this configuration. The cavity exhibits a quality value Q exceeding 2×109 in its TE011 mode with a resonant frequency of 2.689 GHz. Methods of fabrication and testing of the cavity are presented in this article. Since the interface between the film and substrate is exposed to the full value of the resonant magnetic field, our experiment is the most sensitive test to date for enhanced losses at the interface itself. We find no evidence of such losses. In fact, the measured values of the surface resistance match very well predictions for rf losses based on the BCS theory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.336608
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Addition of deoxynucleotides to an RNA primer by a DNA polymerase in human platelets
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 99 (1981), S. 1191-1198 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(81)90745-2
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    An ancestral amplification of DNA in primates
    Amsterdam : Elsevier
    Gene 12 (1980), S. 103-111 
    Details
    ISSN: 0378-1119
    Keywords: DNA library ; Markov chain ; sequence dating
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-1119(80)90020-7
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Divergence of primate ribosomal RNA genes as assayed by restriction enzyme analysis
    Amsterdam : Elsevier
    Gene 11 (1980), S. 89-96 
    Details
    ISSN: 0378-1119
    Keywords: Phylogeny ; RNA-DNA hybridization ; multigene families
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-1119(80)90089-X
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The size structure of a lacustrine zoobenthic community (1986)
    Springer
    Oecologia 69 (1986), S. 513-516 
    Details
    ISSN: 1432-1939
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Data from Mirror Lake, New Hampshire, are used to construct the first quantitative description of the size structure of a freshwater benthic animal community. Size spectra of the benthic animal community, whether expressed as animal density, biomass, species richness, or assimilation, are generally unimodal. These spectra are strikingly different from the characteristically bimodal size spectra reported for marine benthic communities. There is no indication in these size spectra that the meiofauna and macrofauna are distinct ecological entities in Mirror Lake, as has been suggested for marine benthic communities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410356
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  • 6
    Electronic Resource
    Electronic Resource
    A 2-year follow up of babies enrolled in a European multicentre trial of porcine surfactant replacement for severe neonatal respiratory distress syndrome (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 372-376 
    Details
    ISSN: 1432-1076
    Keywords: Respiratory distress syndrome ; Surfactant ; Follow up studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The postnatal growth, respiratory status and neurodevelopmental outcome of surviving babies enrolled in the first European multicentre trial of porcine surfactant (Curosurf) replacement for severe neonatal respiratory distress syndrome, were assessed at corrected ages of 1 and 2 years. Follow up rates of survivors were 93% at 1 year and 89% at 2 years. Treated and control groups were similar at both 1 and 2 years in terms of physical growth, the prevalence of persistent respiratory symptoms and the occurrence of major and minor disability. Serum antibodies recognising Curosurf and surfactant-anti-surfactant immune complexes were detected in both treated and control babies, the titres showing no difference between groups. Examination of histological lung sections from non-survivors revealed a higher incidence of severe pulmonary interstitial emphysema in control babies than in those treated with surfactant. Surfactant treatment for severe respiratory distress syndrome reduces neonatal mortality and air leaks and is not associated with an increase in disability 2 years later.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02113261
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  • 7
    Electronic Resource
    Electronic Resource
    Lung Function and Bacterial Proliferation in Experimental Neonatal Pneumonia in Ventilated Rabbits Exposed to Monoclonal Antibody to Surfactant Protein A (1998)
    Springer
    Lung 176 (1998), S. 123-131 
    Details
    ISSN: 1432-1750
    Keywords: Key words: Antibody—Surfactant protein A—Group B streptococci—Pneumonia.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Surfactant protein A (SP-A) increases the resistance of surfactant to inhibition by plasma and other proteins. In a previous study we found that a monoclonal anti-SP-A antibody (R 5) increased the sensitivity of surfactant to inhibition by fibrinogen in vivo and in vitro. SP-A has been shown to stimulate microbial phagocytosis and killing by alveolar macrophages. We hypothesized that using R 5 to inactivate SP-A in an animal model mimicking congenital group B streptococcal (GBS) pneumonia might result in increased bacterial proliferation and a deterioration in lung function. Newborn near term rabbits were delivered by Cesarean section, anesthetized, tracheotomized, and ventilated for 5 h in a plethysmograph system allowing measurement of dynamic lung-thorax compliance. Postnatally the animals received one intratracheal injection (5 ml/kg) of R 5, nonspecific IgG, or normal saline. At 30 min all animals received a standard dose of an encapsulated GBS strain by intratracheal injection. The number of bacteria (mean log10 CFU/g lung ± S.D.; CFU = colony forming unit) was evaluated in lung homogenates. Histologic lung sections were judged by light microscopy. Bacterial proliferation was similar in rabbits treated with the monoclonal antibody (9.33 ± 0.39; n= 14) and in control animals receiving saline (9.16 ± 0.35; n= 14) or nonspecific IgG (9.26 ± 0.31; n= 11). No significant differences were noted on the histologic analysis or in measurements of lung function. We conclude that intratracheal instillation of a monoclonal anti-SP-A antibody did not increase bacterial proliferation in GBS-infected newborn rabbits. These findings suggest that SP-A does not play an important role in protection against encapsulated GBS strains in the neonatal period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007594
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  • 8
    Electronic Resource
    Electronic Resource
    Results of a double-blind placebo-controlled study of the double-stranded RNA drug polyI:PolyC12U in the treatment of HIV infection (1996)
    Springer
    European journal of clinical microbiology & infectious diseases 15 (1996), S. 580-587 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this multicenter, randomized, double-blind study the activity of polyI:polyC12U administered with zidovudine was evaluated in the treatment of HIV infection. Thirty-six HIV-positive, pre-AIDS individuals (100–500 CD4+ cells/mm3) who had had at least six months of zidovudine therapy received polyI:polyC12U (400 or 700 mg) or placebo twice weekly with zidovudine. PolyI:polyC12U subjects with baseline CD4+ counts≥300/mm3 showed a trend towards reduced CD4+ loss versus placebo recipients. PolyI:polyC12U subjects were more likely to exhibit positive delayed-type hypersensitivity responses than placebo recipients. Placebo subjects crossing over to polyI:polyC12U therapy demonstrated improved CD4+ and delayed-type hypersensitivity responses. PolyI: polyC12U subjects with baseline CD4+ counts≥300/mm3 were less likely to develop AIDS than similar placebo subjects. PolyI:polyC12U therapy of HIV-positive subjects restored or stabilized immune function as indexed by delayed-type hypersensitivity reactivity and, in individuals with CD4+ counts〉300/mm3, abrogated CD4+ loss and reduced disease progression. PolyI:polyC12U was generally well-tolerated in this zidovudine-treated population. No subject discontinued therapy due to an adverse reaction or aberrant laboratory parameter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709367
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