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  • 1
    Digitale Medien
    Digitale Medien
    Infiltration of primary and metastatic melanomas with macrophages of the 25F9-positive phenotype (1987)
    Springer
    Cancer immunology immunotherapy 25 (1987), S. 81-86 
    Details
    ISSN: 1432-0851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In order to gain insight into the role of macrophages in human melanoma, we studied fresh-frozen material from 15 dysplastic nevi, 199 primary melanomas, 107 melanoma metastases, and paraffin sections from 98 primary melanomas with the monoclonal antibody 25F9 which recognizes an 86×103 dalton protein present on a subset of mature human macrophages. Considerable infiltration of tumors with 25F9-positive macrophages was observed in 2 dysplastic nevi (13%), 87 primary melanomas (44%), and 45 metastases (42%). The degree of intratumoral macrophage infiltration correlated with expression of class II HLA-DR antigens on tumor cells, in primary melanoma with a tumor thickness above 0.75 mm, and with the occurence of metastases within 2 years. In paraffin sections, intratumoral 25F9-positive macrophages also correlated with metastatic spread of primary tumors after longer follow-up. Metastases revealed a higher degree of macrophage infiltration following systemic or local immunotherapy, compared with untreated metastases, or metastases removed during chemotherapy. Of 38 patients who died within an observation period of 1 year, 19 (50%) had considerable infiltration of metastases with 25F9-positive macrophages, whereas this was found in only 4 of 12 patients (33%), who survived for longer than 2 years following metastases removal. A higher degree of 25F9-positive macrophages correlated with a shift towards the T8-positive subsets within the T cell compartment of the infiltrate. Our results suggest that accumulation of 25F9-positive macrophages in melanomas indicates more aggressive tumor properties.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00199945
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  • 2
    Digitale Medien
    Digitale Medien
    Clinical findings and immunochemical studies in a patient with cryoglobulinaemia (1980)
    Springer
    Archives of dermatological research 268 (1980), S. 289-296 
    Details
    ISSN: 1432-069X
    Schlagwort(e): Cryoglobulinaemia ; Complement ; Paraprotein ; Vasculitis ; Kryoglobulinämie ; Komplement ; Paraprotein ; Vasculitis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Bei einem Patienten mit IgG3-kappa-Kryoglobulinämie bestanden Purpura, oberflächliche Ulcera und eine Livedo. Das IgG3-Kryoglobulin reagierte mit allen IgG-Subklassen. In frischem EDTA-Plasma war keine Komplementaktivierung nachweisbar. Nach Inkubation mit frischem Normal-serum trat eine fast vollständige Konversion von C3 ein, während eine entsprechende Umwandlung von Faktor B nicht nachweisbar war.
    Notizen: Summary Purpura, shallow ulcers, and livedo were noted in a patient with IgG3-kappa cryoglobulinaemia. The IgG3 cryoglobulin reacted with all IgG subclasses. No complement activation could be demonstrated in fresh EDTA plasma. When the cryoglobulin was incubated with fresh normal serum, almost complete conversion of C3, but not of factor B occurred.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00404291
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  • 3
    Digitale Medien
    Digitale Medien
    Heterogeneity of primary and metastatic human malignant melanoma as detected with monoclonal mntibodies in cryostat sections of biopsies (1983)
    Springer
    Cancer immunology immunotherapy 16 (1983), S. 53-58 
    Details
    ISSN: 1432-0851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Monoclonal antibodies were generated against established melanoma cell lines and characterized by their reactivity with various sublines. The antibodies selected for their reaction with melanoma-associated antigens were tested on cryostat sections of melanoma tissue from various stages and on other tumors. The reactivity with normal tissues was also determined. Of 30 antibodies reacting with melanoma cell lines 11 did not react with melanoma biopsies. Of the remaining 19 antibodies nine displayed broad cross-reactivity with normal cells and structures and other benign or malignant tumor cells. Among the remaining antibodies five types were defined that detected antigens (nevocellular I, nevocellular II, neural, endothelial, basal cell) found on certain normal tissues and structures and on certain tumor phenotypes. Even though there seems to be a tendency for some antigens to be preferentially associated with certain stages of melanoma, it has not yet been possible to establish any clear-cut correlation between the expression of one of the differentiation antigens and a particular stage or malignancy potential of melanoma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00199906
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  • 4
    Digitale Medien
    Digitale Medien
    Ungewöhnliche Strahlenreaktion nach Röntgenweichstrahltherapie bei einer Patientin mit Pemphigus vulgaris (1995)
    Springer
    Der Hautarzt 46 (1995), S. 502-504 
    Details
    ISSN: 1432-1173
    Schlagwort(e): Schlüsselwörter Pemphigus vulgaris ; Röntgenweichstrahltherapie ; Key words Pemphigus vulgaris ; Soft X-ray therapy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary A 71-year-old woman suffered from pronounced erosion of her nose after soft X-ray therapy (total dose 28 Gy, half dose depth 10.5–11.5 mm). 5 weeks after the end of the irradiation no healing tendency was observed. This unusual clinical course was caused by a simultaneously existing pemphigus vulgaris that worsened after radiotherapy, presumably as a consequence of the release of epidermal antigens. In this case it is improbable that the pemphigus was induced by the radiotherapy, as has been reported on several occasions in the literature. However, this possibility cannot be entirely excluded.
    Notizen: Zusammenfassung Bei einer 71jährigen Frau trat nach Röntgenweichstrahltherapie an der Nase (Gesamtdosis 28 Gy, Gewebehalbwerttiefe 10,5–11,5 mm) eine ausgeprägte Strahlenerosion auf. Diese zeigte 5 Wochen nach Ende der Bestrahlung noch keine Tendenz zur Abheilung. Ursache dieses ungewöhnlichen Verlaufes war ein gleichzeitig bestehender Pemphigus vulgaris. Dieser hatte sich nach der Strahlentherapie, vermutlich als Folge einer Freisetzung epidermaler Antigene, verschlimmert. Daß der Pemphigus in diesem Fall durch die Bestrahlung ausgelöst wurde – wie mehrfach in der Literatur berichtet – ist unwahrscheinlich, aber nicht sicher auszuschließen.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001050050291
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  • 5
    Digitale Medien
    Digitale Medien
    p-Glycoprotein expression in malignant melanoma (1991)
    Springer
    Journal of cancer research and clinical oncology 117 (1991), S. 168-171 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Melanoma ; Multidrug resistance ; Permeability glycoprotein
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In some human malignancies resistance to chemotherapy is caused by an energy-dependent efflux system, responsible for the removal of chemotherapeutics out of the resistant tumor cells. A major component of this efflux system is the permeability glycoprotein (p-glycoprotein), which depends on the multidrug-resistance geneMDR1. We have tested p-glycoprotein in primary and metastatic human melanoma by use of the monoclonal antibody C219; a substantial expression was only observed in 1/37 primary melanomas and in 1/27 melanoma metastases. None of the patients with negative metastases responded to chemotherapy. Moreover a complete remission of metastasic growth was observed in the patient with the metastasis significantly expressing the p-glycoprotein. Sequential studies revealed no significant increase of p-glycoprotein-positive cells during and after chemotherapy. We conclude that drug resistance in human melanoma does not usually depend on the p-glycoprotein-related efflux system. Other mechanisms are obviously responsible for drug resistance in this human malignancy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01613142
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  • 6
    Digitale Medien
    Digitale Medien
    Metastatic human melanoma (1989)
    Springer
    Journal of cancer research and clinical oncology 115 (1989), S. 459-464 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Metastatic melanoma ; Heterogeneity ; Clinical course
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary According to animal experiments, metastasis to a particular organ depends on the phenotype of the tumor cells. Widespread metastatic dissemination including internal organs would therefore, at least in part, depend on the capacity of tumor cells to modulate, resulting in increased phenotypic heterogeneity. We found evidence for this assumption in human melanoma by phenotyping metastases (mainly cutaneous/subcutaneous) from 59 patients by the use of six monoclonal antibodies. Interlesional antigenic heterogeneity was present in 22/33 (67%) patients with disseminated metastases including at least one internal organ, but only in 4/26 (15%) patients whose metastases were restricted to skin and/or skin-draining lymph nodes (P≤-0.01). Chemotherapy cannot be the main reason for interlesional phenotypic heterogeneity, as seen by comparison of treated and untreated patients. Aneuploid melanoma metastases, as an indication for instability on the chromosomal level, were found in the majority of patients (84%) regardless of their clinical situation. Widespread disease was significantly related to the loss of the cytoplasmatic antigen K-1-2 and to the expression of the 130-kDa membrane antigen A-1-43.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00393338
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  • 7
    Digitale Medien
    Digitale Medien
    The relationship between characteristics of the tumor cells and sex of the patients in primary malignant melanomas (1991)
    Springer
    Journal of cancer research and clinical oncology 117 (1991), S. 364-366 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Antigen expression ; Sex ; Prognosis ; Malignant melanoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Sex is a well proven prognosticator in primary malignant melanoma. We studied 19 parameters of tumor cells in primary malignant melanoma from 391 patients, the purpose being to determine if melanomas in men and women are alike. Apart from results in thin melanomas, no difference was seen between the sex groups. Thin melanomas showed a significant difference for the melanoma-associated antigen G7-E2 (higher expression in women) and the histocompatibility antigen HLA-DR (higher expression in men). The results suggest that sex-related prognostic differences are due more to host than to tumor characteristics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01630721
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  • 8
    Digitale Medien
    Digitale Medien
    Die Strukturregel der Antikörper und das Antikörperproblem (1970)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 82 (1970), S. 556-556 
    Details
    ISSN: 0044-8249
    Schlagwort(e): Chemistry ; General Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ange.19700821421
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