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  • 1
    Electronic Resource
    Electronic Resource
    Immunological detection of O6-methylguanine in alkylated DNA (1978)
    s.l. : American Chemical Society
    Biochemistry 17 (1978), S. 1896-1901 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00603a015
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  • 2
    Electronic Resource
    Electronic Resource
    Antinuclear Antibodies in Scleroderma (1981)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 20 (1981), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1981.tb00835.x
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  • 3
    Electronic Resource
    Electronic Resource
    Plasma complement and histamine changes in atopic dermatitis (1979)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 100 (1979), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Fifteen patients with atopic dermatitis were investigated to evaluate the total of complement and histamine. In five patients total serum complement haemolytic activity (CH50) was significantly decreased as was the haemolytic activity of complement components C2 (C2H50) and C3 (C3H50) By counter immunoelectrophoresis split products of C3 were detected. There was no evidence for alternative pathway activation or the presence of an activator of the alternative pathway. In three patients plasma histamine concetrations were elevated. The intensity of the complement and histamine changes observed seemed to be correlated to the severity of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1979.tb05577.x
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  • 4
    Electronic Resource
    Electronic Resource
    Complement and immunoglobulin deposits in the skin of patients with atopic dermatitis (1978)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 99 (1978), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The immunofluorescent patterns of uninvolved and involved skin biopsies from eight patients with atopic dermatitis were studied, using direct immunofluorescence techniques to identify deposits of the immunoglobulins G, A and M as well as the complement factors CIq, C3, C4, C5, factor B and properdin. Immunoglobulin deposits (mainly IgG) were found in five patients, complement deposits in three patients in the basement membrane zone. In three patients the immunofluorescence was positive for C3, in two patients for CIq, C4 and C5. Regarding the factors of the alternative pathway of the complement system, two patients showed deposits of properdin, one of factor B.The changes were not confined to the eczematous lesions, but were found in uninvolved skin too. The most prominent changes were observed in patients with severe disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1978.tb02016.x
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  • 5
    Electronic Resource
    Electronic Resource
    Heterochromatin protein HP1Hsβ(p25β) and its localization with centromeres in mitosis (1997)
    Springer
    Chromosoma 106 (1997), S. 11-19 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Some autoimmune sera containing anticentromere autoantibodies also recognize a doublet of Mr 23 000 (p23) and 25 000 (p25) in addition to CENP (centromere protein)-A (Mr 19 000), -B (Mr 80 000), and -C (Mr 140 000). A p25 antigen (HP1Hsα) has been shown to be a human homolog of Drosophila HP1 (heterochromatin protein 1). We have isolated a cDNA clone encoding another form of p25 (HP1Hsβor p25β) from a λZap HepG2 library using human autoimmune serum. The deduced amino acid sequence of the clone contained a conserved chromodomain (chromatin modifier domain) in the N-terminal region and a heterochromatin binding domain in the C-terminal region. In immunofluorescence experiments, only affinity purified antibodies reactive with the C-terminal (amino acids 70–185) domain showed nucleoplasmic and heterochromatin staining, whereas N-terminal (amino acids 1–115) specific antibodies were nonreactive. In metaphase chromosome spreads, the C-terminal domain antibody was also localized to the centromeric regions of chromosomes. Association with centromeres was most prominent at anaphase and changed to a more generalized association with whole chromosomes in telophase. The cooccurrence of autoantibodies to centromere proteins and HP1 in certain autoimmune diseases might be a reflection of coordinated immune responses to these closely associated sets of proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004120050219
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  • 6
    Electronic Resource
    Electronic Resource
    Epstein-Barr (EB)virus antibodies in rheumatoid arthritis (1981)
    Springer
    Springer seminars in immunopathology 4 (1981), S. 181-191 
    Details
    ISSN: 1432-2196
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It is now known that the sera of patients with rheumatoid arthritis (RA) contain antibodies directed to a nuclear antigen, RANA (RA-associated nuclear antigen), present in Epstein-Barr virus (EBV) infected cells. These antibodies are present in a majority of RA patients but are found in low frequencies in other rheumatic diseases. In addition to anti-RANA, other EBV antibodies such as antiviral capsid antigen (VCA) are present in elevated titers and anti-early antigen (EA) are present in elevated titers and increased frequency. Investigations of RA lymphocytes after in vitro EBV infection have revealed aberrant immune regulation of EBV infection and markedly increased rheumatoid factor production by RA lymphocytes. Although there is increasing evidence associating EBV with RA, the precise role of this virus in the pathogenesis of RA is not known at this time but further studies designed to explore virus-host immune interactions would appear to be most important.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01857094
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  • 7
    Electronic Resource
    Electronic Resource
    Autoantibodies to native myeloperoxidase in patients with pulmonary hemorrhage and acute renal failure (1991)
    Springer
    Journal of clinical immunology 11 (1991), S. 389-397 
    Details
    ISSN: 1573-2592
    Keywords: Antineutrophil cytoplasmic autoantibodies ; antimyeloperoxidase autoantibodies ; glomerulonephritis ; pulmonary hemorrhage syndromes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sera from 245 patients were screened by indirect immunofluorescence for perinuclear/nuclear staining (P-ANCA) of ethanol-fixed neutrophils, a staining pattern which is associated with the presence of antibodies to myeloperoxidase. Using immunoblot and immunoprecipitation techniques on 15 P-ANCA-positive sera, 13 patients demonstrated antibody to purified or native myeloperoxidase but not to denatured myeloperoxidase. In patients with P-ANCA, the most frequent reason for medical attention was hemoptysis (8/13; 62%). Of the 15 sera with P-ANCA, acute renal failure was identified in 9 patients (60%). Five patients (33%) had both. All patients (eight of eight) with hemoptysis had antibodies which bound functional MPO as compared to three of seven P-ANCA-positive patients without hemoptysis (P〈0.001), suggesting that antibodies which recognize conformational sites on native myeloperoxidase occur in a subgroup of patients with alveolar hemorrhage as their presenting clinical sign. These findings may provide insight into the disease process associated with P-ANCA. We further identify a subgroup of patients with a severe pulmonorenal syndrome and antibodies recognizing native myeloperoxidase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00918805
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  • 8
    Electronic Resource
    Electronic Resource
    Immunocytochemical characterization of human NOR-90 (upstream binding factor) and associated antigens reactive with autoimmune sera (1994)
    Springer
    Molecular biology reports 19 (1994), S. 115-124 
    Details
    ISSN: 1573-4978
    Keywords: autoantibody ; human upstream binding factor ; nucleolus organizer region ; RNA polymerase I ; RNA polymerase II
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The 90-kDa nucleolus organizer region autoantigen (NOR-90) was previously shown to be identical to the human upstream binding factor (hUBF) and composed of twoMr forms. In this study, thirteen human anti-NOR-90/hUBF autoimmune sera were used to further characterize NOR-90/hUBF and its associated autoantigens. Nucleolar and nucleoplasmic staining of interphase cells and NOR staining in mitosis were observed with all sera by immunofluorescence. All sera showed equal reactivity with both high and lowMr forms in Western blotting and immunoprecipitation, suggesting that the cellular content and distribution for bothMr forms were approximately equal. Using extracts of [35S]methionine- and [32P]orthophosphate-labeled cells, phosphorylated and nonphosphorylated NOR-90/hUBF were identified for bothMr forms and these two populations were recognized by human autoantibodies. In immunoprecipitation analyses, the nonphosphorylated population was readily extracted while the phosphorylated population was tightly bound. Clinical data were available for 8 patients in whom anti-NOR-90/hUBF autoantibodies were present. They had diverse diagnoses including SLE, rheumatoid arthritis and malignancies. Although only one patient was diagnosed as scleroderma, Raynaud's phenomenon was observed in 4 of the 8 patients. Interestingly, one NOR-90/hUBF serum was shown to contain additional antibodies to RNA polymerases I and II.Abbreviations: ANA=Antinuclear antibody; HCC=hepatocellular carcinoma; hUBF=human upstream binding factor; NOR=nucleolus organizer region; RNA pol I=RNA polymerase I; RNA pol II=RNA polymerase II; rRNA=ribosomal RNA; SLE=systemic lupus erythematosus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00997157
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  • 9
    Electronic Resource
    Electronic Resource
    Molecular characterization and cloning of the 52kDa SS-A/Ro protein (1990)
    Springer
    Molecular biology reports 14 (1990), S. 53-53 
    Details
    ISSN: 1573-4978
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00360413
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  • 10
    Electronic Resource
    Electronic Resource
    Antinuclear autoantibodies: probes for defining proteolytic events associated with apoptosis (1996)
    Springer
    Molecular biology reports 23 (1996), S. 211-216 
    Details
    ISSN: 1573-4978
    Keywords: apoptosis ; autoantibodies ; ICE/CED-3 proteases ; nuclear autoantigens ; proteolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Antinuclear autoantibodies (ANAs) derived from patients with systemic autoimmune diseases have proven to be powerful tools in cell and molecular biology. The availability of these autoantibodies has been instrumental in the identification and characterization of a wide range of intracellular proteins involved in essential cellular activities. Recently, these autoantibodies have been used in molecular studies of apoptosis, particularly in the identification of substrates cleaved by proteases of the ICE/CED-3 family during this cell death pathway. The identification of these substrates may help to understand the role of proteolysis in apoptosis. Examples of nuclear autoantigens whose cleavage during apoptosis have been defined using ANAs include the 70 kD protein of the U1 small nuclear ribonucleoprotein particle (U1-70 kD), the nuclear mitotic apparatus protein (NuMA), DNA topoisomerase I, the RNA polymerase I upstream binding factor (UBF), and the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs). The use of ANAs as probes for defining proteolytic events associated with apoptosis promises to yield important insights into the mechanisms driving this cell death pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00351171
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