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  • 1
    Electronic Resource
    Electronic Resource
    Ion chromatographic separation of anions on silica-coated polyamide crown resin (1981)
    s.l. : American Chemical Society
    Analytical chemistry 53 (1981), S. 1942-1944 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac00235a053
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  • 2
    Electronic Resource
    Electronic Resource
    Heart Rate Variability in Patients with Familial Amyloid Polyneuropathy (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Pacing and clinical electrophysiology 20 (1997), S. 0 
    Details
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this study was to evaluate heart rate variability (HRV) in patients with familial amyloid polyneuropathy (FAP) using the time- and frequency-domain analysis. The study population consisted of 19 patients with FAP, and 19 age and sex matched normal volunteers. The 24-hour Holter recordings of all subjects in sinus rhythm and off medication were analyzed. Five time-domain indices of HRV were computed. The frequency component of HRV was calculated by fast Fourier transform analysis of the RR intervals. The power spectrum of the low frequency (LF) between 0.04–0.15 Hz and high frequency (HF) between 0.15–0.40 Hz and the LF/HF ratio was calculated. Global measures of HRV including the standard deviation of the mean of RR intervals (SDNN) and the standard deviation of 5-minute mean RR intervals (SDANN) were decreased in patients with FAP. Specific vagal influences on HRV including the proportion of RR intervals more than 50 milliseconds different (pNN50) and the HF power on spectral analysis were less in patients with FAP. LF power and LF/HF ratio were more decreased in patients with FAP at the advanced stage than at the early stage. In conclusion, HRV was significantly decreased in patients with FAP at the early stage, and sympathetic activity was more decreased in patients at the advanced stage. These findings suggest that the decrease of the HRV is an indicator of this disease and the power spectral analysis of the HRV is beneficial in assessing the severity of the autonomic dysfunction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8159.1997.tb05465.x
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  • 3
    Electronic Resource
    Electronic Resource
    Circulating current generation through a macromosaic cell and separation of electrolytes from nonelectrolytes (1985)
    s.l. : American Chemical Society
    Industrial and engineering chemistry 24 (1985), S. 485-488 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/i100020a013
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  • 4
    Electronic Resource
    Electronic Resource
    General synthesis of phenanthroindolizidine, phenanthroquinolizidine, and related alkaloids: preparation of (.+-.)-tylophorine, (.+-.)-cryptopleurine, (.+-.)-septicine, and (.+-.)-julandine (1984)
    s.l. : American Chemical Society
    The @journal of organic chemistry 49 (1984), S. 2412-2418 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00187a022
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  • 5
    Electronic Resource
    Electronic Resource
    Synthesis of (.+-.)-lasubine I and II, and (.+-.)-subcosine I (1984)
    s.l. : American Chemical Society
    The @journal of organic chemistry 49 (1984), S. 1909-1912 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00185a012
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  • 6
    Electronic Resource
    Electronic Resource
    Emergency decompression of bile duct in acute obstructive suppurative 3 cholangitis by duodenoscopic cannulation: A lifesaving procedure (1981)
    Springer
    World journal of surgery 5 (1981), S. 587-593 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'angiocholite aigüe obstructrive suppurée est une affection extrÊmement grave, caractérisée par des douleurs abdominales, de l'ictère, une fièvre hectique, un état de choc, une dépression neuro-psychique. Les calculs biliaires sont, de loin, la cause la plus fréquente d'obstruction. La maladie a une mortalité de presque 100% si l'on ne réalise pas d'urgence une décompression du cholédoque. Ceci peut Être réalisé par fibroscopie, avec introduction dans la voie biliaire d'un cathéter de large diamètre. Trois patientes traitées récemment à l'HÔpital Universitaire de Kyushu sont présentées. Il s'agissait de 3 femmes avec obstruction par calcul. Ceux-ci, bloqués dans le cholédoque distal, ont pu Être désimpactés par endoscopie, permettant ainsi le drainage de la bile purulente et l'amélioration rapide des symptÔmes. La décompression endoscopique est une technique rapide, sûre et efficace pour le traitement d'urgence de l'angiocholite aigüe obstructive suppurée.
    Notes: Abstract Acute obstructive suppurative cholangitis is a life-threatening condition characterized by abdominal pain, jaundice, spiking fever, shock, and central nervous system depression. Biliary calculi are by far the most common obstructing mechanism. This entity carries an almost 100% mortality unless early decompression of the obstructed common bile duct is performed. With recent progress in duodenofiberscopy, this can be accomplished by endoscopic cannulation using a large-calibre stiff catheter. Three consecutive patients recently treated in the Kyushu University Hospital are presented. All were female and a stone was the cause of the obstruction in all. The stones impacted at the distal common bile duct of these patients were dislodged by endoscopic cannulation, resulting in a release of purulent bile and a dramatic improvement in the symptoms and signs. Endoscopic decompression is a quick, safe, and effective procedure for emergency treatment of acute obstructive suppurative cholangitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01655014
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  • 7
    Electronic Resource
    Electronic Resource
    Clinicopathologic Differences between Long-Term and Short-Term Postoperative Survivors with Advanced Gallbladder Carcinoma (1997)
    Springer
    World journal of surgery 21 (1997), S. 98-102 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The objective of this study was to determine histopathologic factors that influence the failure or success of extended cholecystectomy and more aggressive surgery to attain long-term survival in patients with advanced carcinoma of the gallbladder. Of 46 patients with carcinoma of the gallbladder who had undergone surgical resection, 36 had advanced carcinoma invading to or beyond the subserosal layer. Among these 36 patients were 10 long-term survivors (〉 5 years) and 11 short-term survivors who died of recurrence (〈 37 months) after extended cholecystectomy or more extensive surgery. Factors were compared between the two groups. Significant factors observed in the long-term survivors were the depth of invasion limited to the subserosal layer ( p 〈 0.05), hepatic infiltration 〈 5 mm ( p 〈 0.01), histologic grade of papillary or well differentiated adenocarcinoma ( p 〈 0.01), absent or minimal venous, lymphatic, and perineural invasion ( p 〈 0.01), and lymph node metastasis limited to the hepatoduodenal ligament ( p 〈 0.05). It was concluded that the patients with subserosal invasion have a hope for long-term survival by extended cholecystectomy or more aggressive surgery when hepatic infiltration and venous, lymphatic, and perineural invasion are absent or minimal, the histologic grade is papillary or well differentiated adenocarcinoma, and lymph node metastasis is limited to the hepatoduodenal ligament.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002689900200
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  • 8
    Electronic Resource
    Electronic Resource
    Role of Surgery for Gallbladder Carcinoma with Special Reference to Lymph Node Metastasis and Stage Using Western and Japanese Classification Systems (2000)
    Springer
    World journal of surgery 24 (2000), S. 1271-1277 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The role of radical resection in the treatment of gallbladder carcinoma was examined with special reference to lymph node metastasis using two classifications: one proposed by the American Joint Committee on Cancer (AJCC) and the other by the Japanese Society of Biliary Surgery (JSBS). Histologic evaluations for the depth of tumor invasion (T), lymph node metastasis (N), stage, and follow-up for a mean period of 38 months (range 4–185 months) were completed in 52 patients with gallbladder carcinoma who underwent surgical resection from 1982 to 1997. The definition of T was similar in the two classifications. The extent of nodal involvement (N, AJCC; n, JSBS), stage, and survival were examined. In the absence of lymph node metastasis, the 5-year survival rate reached 71%. The 5-year survival rate in patients with involved nodes confined to the hepatoduodenal ligament, posterosuperior pancreaticoduodenal region, or along the common hepatic artery (N1 and part of N2 by AJCC; n1 and n2 by JSBS) approximated 28%. In contrast, postoperative survival was poor in the presence of more extensive nodal involvement (rest of N2 by AJCC; n3 and n4 by JSBS), with no 2-year survivors. The definition of stage I was the same in both classifications, and all patients in this stage are alive. The 5-year survival rates in stages II and III by the AJCC were 70.7% and 22.4%, respectively, and those by JSBS 61.9% and 23.1%, respectively. Thus the survival rates in stages I to III were essentially similar irrespective of the staging system. Stage IV showed significantly worse survival than stage III by the JSBS classification. In contrast, the differentiation of stage IV from III by the AJCC was not significant because of the better survival in stage IV that contained any T with nodal involvement in the posterosuperior pancreaticoduodenal region and along the common hepatic artery. Radical resection should be considered for patients with stage I to III disease defined by either classification and applied to the tumor invasion up to T3 with nodal involvement confined to the hepatoduodenal ligament, posterosuperior pancreaticoduodenal region, and along the common hepatic artery. The role of radical surgery seems to be limited in patients with more extensive tumor invasion or lymph node metastasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002680010253
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  • 9
    Electronic Resource
    Electronic Resource
    Comparison of Routine and Selective Endoscopic Retrograde Cholangiography before Laparoscopic Cholecystectomy (1996)
    Springer
    World journal of surgery 20 (1996), S. 267-271 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. To evaluate the role of endoscopic retrograde cholangiography (ERC) before laparoscopic cholecystectomy, we compared the frequency of concomitant common bile duct stones, their clinical outcome, and the frequency of bile duct injury between a group of 128 patients with routine preoperative ERC (group A) and 1010 patients with selective ERC (group B). Overall, 48 patients (4.2%) had duct stones, but the predictive signs were absent in six of them (12.5%). The stones were demonstrated by ERC and removed by sphincterotomy in all 11 patients in group A. Of 37 patients in group B, 22 were diagnosed by selective ERC and underwent endoscopic removal. Of four patients whose stones were found by operative cholangiography, one had immediate open surgery, another passed a stone spontaneously, and the other two underwent postoperative sphincterotomy, which failed in one. The stones were not recognized until pain recurred in the remaining 11 patients. Sphincterotomy was successful in nine patients but failed in the other two. Thus postoperative sphincterotomy failed in 3 of 13 patients (23%), necessitating open surgery. Forty-two patients overall (3.7%) had aberrant biliary tract anatomy, which did not lead to bile duct injury in any of the patients. Morbidity of routine ERC (3.1%) was lower than that of selective ERC (7.4%) ( p 〈 0.05). It should be noted that a certain proportion of duct stones may be missed by selective ERC, necessitating laparotomy when sphincterotomy fails. The routine use of preoperative ERC may be justified at institutions where the expertise is available, at least until laparoscopic lithotomy becomes easy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002689900042
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  • 10
    Electronic Resource
    Electronic Resource
    Expression of Inducible Nitric Oxide Synthase in Circulating Neutrophils of the Systemic Inflammatory Response Syndrome and Septic Patients (1998)
    Springer
    World journal of surgery 22 (1998), S. 771-777 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. There is increasing evidence that nitric oxide (NO) is an important factor in the pathogenesis of septic shock. It is known that polymorphonuclear neutrophils (PMNs) are activated during sepsis or after surgical stress, and they then release various toxic mediators including free radicals. It has not been clear whether NO synthesis can be induced in circulating PMNs. Blood samples were obtained from 11 patients with sepsis, 23 patients with systemic inflammatory response syndrome (SIRS), and 16 patients without SIRS (nonSIRS) who underwent operation. We examined mRNA expression of inducible NO synthase (iNOS) in circulating PMNs from those patients pre- and postoperatively using the reverse transcriptase polymerase chain reaction (RT-PCR) method and measured their serum nitrate (NO2 \-) + nitrate (NO3 \-) concentration, peripheral blood white blood cell (WBC) count, and serum C-reactive protein (CRP) level. The frequency of iNOS expression in PMNs increased in sepsis (100%) and SIRS (70%) patients compared to that in nonSIRS patients (18%) ( p 〈 0.001). The peripheral WBC count and CRP level were significantly higher in iNOS-positive patients than in iNOS-negative patients ( p 〈 0.05 and p 〈 0.01, respectively). Postoperatively, the serum NO 2 \- + NO 3 \- concentration increased in 87% of septic patients and in 56% of patients with SIRS ( p 〈 0.05 for both). Our study indicated that iNOS mRNA expression is induced in human circulating PMNs of patients with postoperative sepsis and SIRS and may be involved in the pathogenesis of the sepsis syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002689900468
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