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  • 1
    Electronic Resource
    Electronic Resource
    Microwave Coagulonecrotic Therapy for Hepatocellular Carcinoma (1996)
    Springer
    World journal of surgery 20 (1996), S. 1076-1081 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The present study reports on the usefulness of microwave coagulonecrotic therapy (MCT) as a treatment option for hepatocellular carcinoma (HCC) with poor hepatic reserve. From June 1992 to March 1995, MCT using a microwave electrode was employed on 8 patients using laparoscopic control and 19 with the open method, and wedge resection (Hx) was applied to the 23 patients. All patients had HCC with poor hepatic reserve. Radiation output was 100 watts with a mean radiation duration of about 30 minutes. The severity of liver dysfunction and the regional characteristics of the tumor (tumor size, multiplicity, portal invasion, tumor depth) were comparable between the MCT and Hx groups. The operative time was significantly shorter for the MCT group than the Hx group. The mean blood loss was 1570 ml in the Hx group but negligible in the MCT group. There was no operative mortality in the MCT group in contrast to 4.3% (1 of 23) in the Hx group. Complications were observed in 11.1% (3 of 27) and 34.8% (8 of 23), respectively, for the MCT and Hx groups. The postoperative total bilirubin had lower values and the start of diet was earlier in the MCT group than the Hx group. The 3-year crude and disease-free survival rates were 86% and 44%, respectively, for patients who underwent MCT, which were comparable to 75% and 14% for those with Hx. MCT can achieve long-term results equivalent to those obtained by wedge resections, but it is less invasive and technically easier. Therefore it can be an alternative option in place of limited resection for HCC with poor hepatic reserve.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002689900163
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  • 2
    Electronic Resource
    Electronic Resource
    Optimal route of administration of mixed endothelin receptor antagonist (TAK-044) in liver transplantation (2000)
    Springer
    Journal of gastroenterology 35 (2000), S. 120-126 
    Details
    ISSN: 1435-5922
    Keywords: Key words: liver transplantation, endothelin, endothelin receptor antagonist, TAK-044, ischemia-reperfusion injury
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: It is well known that endothelin-1(ET-1) is a factor involved in the pathogenesis of ischemia-reperfusion injury. This study was undertaken to investigate the optimal route (intravenous vs intraportal) for administering mixed endothelin receptor antagonist (TAK-044) in a liver transplantation. First, in a rat isolated liver cold-perfusion model, the pharmacodynamics of TAK-044 and endothelin-1 (ET) in the liver tissue and the systemic circulation after cold perfusion were compared in the different administration routes. Next, in a rat orthotopic transplantation model, we compared the hepatoprotective effect of TAK-044 among different administration routes. In each model, there were three groups: IV group, intravenous injection of TAK-044 (10 mg/kg) immediately before cold perfusion or an-hepatic phase; IP group, intraportal administration with cold perfusion solution or with reflush solution for the graft; control group, no treatment. In the cold perfusion model, liver tissue ET level increased to a similar extent after reperfusion in the three groups, and the plasma and liver tissue TAK-044 concentrations after reperfusion were highest in the IV group. However, the increase in plasma ET was also greatest, and therefore, the ratio of liver tissue to plasma TAK-044 was lower in the IV group compared with the IP group. In the transplantation model, elevation of plasma ET was significantly higher in the IV group. Leakage of serum alanine aminotransferase (ALT), sinusoidal narrowing, and cell swelling after grafting were significantly suppressed in the IP group. We conclude that intraportal administration before reperfusion offers more efficient accumulation of TAK-044 in the liver tissue, without harmful systemic elevation of ET, and achieves a hepatoprotective effect on the graft compared with intravenous administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005350050024
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  • 3
    Electronic Resource
    Electronic Resource
    Altitude variation of ultraviolet oxygen night airglow (1985)
    Springer
    Astrophysics and space science 114 (1985), S. 387-393 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Night airglow of oxygen 130.4 and 135.6 nm emissions was measured by a spectrophotometer aborad an S520 sounding rocket, launched at 19:50 JST (10:50 UT) on 14 February, 1982 from Kagoshima, Japan. The altitude variation of the emissions was obtained from 110 to 266 km at zenith angles of 35.5°±4°. The emission intensity around 260 km was about 160R and is roughly compatible with model calculations taking account of O++e − radiative recombination as well as O+−O− mutual neutralization. Some excess of about 50R, compared to the model calculation, was observed around 200 km. Possible explanations of the excess are: (i) remnant oxygen ions during the transition period from day to night and (ii) diffuse radiation from the background sky. Model calculations taking account of remnant oxygen ions were also performed by adding an excess electron density to the original density profile. However, it was found that an unreasonably large electron density is required around 200 km (∼5×105 cm−3) to produce the observed intensity. It is also probable that some contribution from the background sky is present in the observed intensity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00653985
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  • 4
    Electronic Resource
    Electronic Resource
    Multivariate analysis of liver regenerative capacity after hepatectomy in humans (1997)
    Springer
    Journal of hepato-biliary-pancreatic surgery 4 (1997), S. 78-82 
    Details
    ISSN: 1436-0691
    Keywords: liver regeneration ; hepatectomy ; liver fibrosis ; multiple regression equation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Many factors affect liver regeneration after partial hepatectomy; however, those factors that are essential for regulation of liver regeneration in humans are not known. Using multiple regression analysis we conducted a study to determine essential factors involved in the speed of liver regeneration after hepatectomy. The subjects were 59 patients who underwent hepatic resection between January 1980 and December 1991. A regression equation for predicting regeneration speed (Y; cm3/day) during the 1st postoperative month was obtained by stepwise forward multiple regression analysis, using 11 explanatory parameters (Xi). The regeneration speed and the resection ratio (%; indicating the magnitude of resection) were calculated based on a computed tomography (CT) scan volumetric study. The degree of liver fibrosis, expressed as the fibrotic index (%), was morphometrically determined in Azan-Mallory stained sections. Of the 11 explanatory parameters, the resection ratio and the fibrotic index had a significant simple correlation with Y. The following regression equation was obtained: Y (cm3/day)=−1.1+3.7 × resection ratio −5.4 × alkaline phosphatase −3.7 × fibrotic index +1.2× total bilirubin −2.6 × glutamic pyruvic transaminase (multiple correlation coefficient, 0.82). We found that the extent of resection and the degree of fibrosis, as well as alkaline phosphatase, total bilirubin, and glutamic pyruvic transaminase, contributed to the speed of regeneration after partial hepatectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01211346
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  • 5
    Electronic Resource
    Electronic Resource
    Idiopathic benign biliary stricture (1998)
    Springer
    Journal of hepato-biliary-pancreatic surgery 5 (1998), S. 463-466 
    Details
    ISSN: 1436-0691
    Keywords: Key words: benign biliary stricture ; localized primary sclerosing cholangitis ; extrahepatic bile duct
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: A rare case of idiopathic benign biliary stricture is reported. A 50-year-old man with liver dysfunction underwent ultrasonography, which revealed dilation of the intrahepatic bile ducts, and endoscopic retrograde cholangiopancreatography, which revealed a short, ring-like stenosis at the junction of the left and right hepatic ducts. Although a benign stricture was suspected, radiologic tests alone were insufficient to make a firm diagnosis. Therefore, a cholecystectomy and resection of the extrahepatic biliary tract were performed. Microscopic examination of the resected specimen demonstrated no evidence of malignancy. The final diagnosis was mild, localized, chronic cholangitis. The patient had not had previous biliary tract surgery, choledocholithiasis, nor did he have a congenital abnormality of the biliary tract, bile duct carcinoma, or pancreatic disease. Since there was no evidence of primary sclerosing cholangitis, the stricture was considered to be idiopathic.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005340050074
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