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  • 1
    Electronic Resource
    Electronic Resource
    Identification of the gene responsible for gelatinous drop-like corneal dystrophy (1999)
    [s.l.] : Nature America Inc.
    Nature genetics 21 (1999), S. 420-423 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Gelatinous drop-like corneal dystrophy (GDLD; OMIM 204870) is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness, with an incidence of 1 in 300,000 in Japan. Our previous genetic linkage study localized the gene responsible to a 2.6-cM interval on ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/7759
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  • 2
    Electronic Resource
    Electronic Resource
    Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens (2003)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 424 (2003), S. 1071-1074 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The eye lens is composed of fibre cells, which develop from the epithelial cells on the anterior surface of the lens. Differentiation into a lens fibre cell is accompanied by changes in cell shape, the expression of crystallins and the degradation of cellular organelles. The loss of organelles ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature01895
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  • 3
    Electronic Resource
    Electronic Resource
    Intraocular oxygen tension in eyes with proliferative diabetic retinopathy with and without vitreous (1996)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 234 (1996), S. S66 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract • Background: Intraocular oxygen tension was measured in the eyes of patients with proliferative diabetic retinopathy with or without vitreous in order to determine local differences in tissue oxygenation in the vitreous cavity before and after vitrectomy. • Methods: We measured oxygen tension, using polarographic oxygen electrodes, at various intraocular locations in 30 eyes of 29 patients with diabetic traction retinal detachment who were candidates for vitrectomy (pre-vitrectomy group) and 13 eyes of 13 diabetic patients who had previously undergone vitrectomy (post-vitrectomy group). • Results: In the pre-vitrectomy group, oxygen tensions proximal to the neovascularization of the disc and the neovascularization elsewhere were significantly higher than the values obtained at other locations in the vitreous cavity. In the post-vitrectomy group, however, the oxygen tensions at those locations were significantly lower than those in the pre-vitrectomy group. There were no significant differences between the values obtained at any of the measurement locations in the post-vitrectomy eyes. • Conclusion: Neovascular tissues in the eyes of diabetic patients demonstrated higher oxygen tensions than non-neovascular tissues. This finding suggests that neovascular tissue may compensate for intraocular hypoxia by releasing oxygen from the front. Successful diabetic vitrectomy reduces the activity of the neovascular tissue and equalizes levels of oxygenation in the tissue of the vitreous cavity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02343050
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  • 4
    Electronic Resource
    Electronic Resource
    Immunohistochemical distribution of basic fibroblast growth factor in experimental retinal ischaemia and reperfusion in the rat (1996)
    Springer
    Journal of molecular histology 28 (1996), S. 607-611 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary It has been proposed that basic fibroblast growth factor (basic FGF) mediates the neovascular response in a variety of conditions, including diabetic retinopathy and branch retinal vein occlusion. To test the hypothesis that basic FGF was released from retinal stores as a result of retinal ischaemia, transient retinal ischaemia was induced, followed by 48 h of reperfusion, in the rat by combined central retinal vasculature and optic nerve ligation. The immunolocalization of basic FGF was studied in the retina. We found that basic FGF in the normal retina is present around the deeper retinal vessels and in the neuronal tissue of the outer plexiform layer. In the eyes that had ischaemia followed by reperfusion, there was moderate cellular oedema with retinal swelling, and mitoses in the inner nuclear and plexiform layers. There were no changes evident at the immunohistochemical level either in the intensity or distribution of stores of basic FGF. We conclude from these data that stores of basic FGF are not altered dramatically under the conditions of transient experimental ischaemia and reperfusion in the rat, despite the presence of cellular proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02331381
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  • 5
    Electronic Resource
    Electronic Resource
    Horizontal transposition of vertical rectus muscles for treatment of excyclotropia (1997)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 235 (1997), S. 1-4 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract • Background: Horizontal transposition of the vertical rectus muscles has been performed for treatment of excyclotropia associated with congenital absence of the superior oblique, and for residual excyclotropia after the Harada-Ito operation. However, the amount of excyclotropia that can be corrected and whether this technique alters the vertical muscle balance is not well known. We report the surgical results of three patients with pure excyclotropia who underwent unilateral one-half tendon width horizontal transpositions of vertical rectus muscles. • Methods: A one half muscle width temporal transposition of the superior rectus and nasal transposition of the inferior rectus muscles of one eye was per formed in three patients with pure excyclotropia and no associated hypertropia. All three had intermittent torsional diplopia before surgery. • Results: Postoperatively, excyclotropia decreased significantly in all fields of gaze, with 8° of reduction by synoptophore and 12.3° of reduction by fundus photography on average. There was no associated vertical or horizontal deviation. All three patients reported improvements of cyclofusion. • Conclusion: One-half muscle width temporal transposition of the superior rectus and nasal transposition of the inferior rectus muscles was effective in ameliorating excyclotropia and corrected subjective complaints without altering vertical muscle balance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01007829
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  • 6
    Electronic Resource
    Electronic Resource
    Exotropia secondary to vitreous hemorrhage (1997)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 235 (1997), S. 143-148 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract • Background: Diplopia after cataract surgery has been reported by several authors, but diplopia after recovery from vitreous hemorrhage (VH) has not been described. •Methods: We examined eight patients with manifest exotropia and binocular diplopia after recovery from dense VH by vitreous surgery. VH was bilateral in three patients and unilateral in five, and lasted for an average of 7.7 years. • Results: Visual acuity before vitrectomy ranged from 20/200 to light perception; that after vitrectomy ranged from 20/20 to 20/60. Exotropia was present in all patients after vitrectomy. Additionally, seven out of eight patients had vertical strabismus with an average deviation of 6 prism diopters (Δ). Fusion was confirmed in four patients with an average amplitude of 13 Δ. Four patients underwent horizontal strabismus surgery. Fusion was present in two before strabismus surgery and in all four after surgery; however, unstable diplopia persisted in three of the four after surgery. • Conclusion: Diplopia after vitrectomy for longstanding VH may occur due to fusion impairment comparable to that occasionally seen after surgery for traumatic cataract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00941721
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  • 7
    Electronic Resource
    Electronic Resource
    Retinal function with lens-induced myopia compared with form-deprivation myopia in chicks (1997)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 235 (1997), S. 320-324 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract • Background: The retina is known to be involved in the development of form-deprivation myopia (FDM); however, it is not clear whether the retinal changes that lead to lens-induced myopia (LIM) are the same as those involved in FDM. To gain insight into the retinal mechanism(s) that cause myopia, we investigated differences in the results of electroretinography (ERG) in eyes with FDM and LIM. • Methods: LIM or FDM was induced in chick eyes by placing various powers of spectacles or an occluder over the left eyes of 6-day-old chicks. After 6 days, the spectacles or occluder was removed, refraction and axial length were measured and ERG was performed. Results for eyes treated with spectacles and those treated with occluders were compared. • Results: Refraction and axial length changed concomitant with the power of the lens used, but components of the ERG of eyes with LIM were not related to the power of lens added. Refraction and axial lengths of eyes covered with a — 16 D lens did not differ from these values in eyes covered with an occluder. The a- and b-waves were also similar for the two groups. However, oscillatory potentials decreased significantly in the chicks with FDM. • Conclusion: Retinal function differs in LIM and FDM, as indicated by differences in the oscillatory potentials. This difference may stem from the fact that in FDM the retinal image is continuously defocused, whereas images are ultimately focused on the retina in LIM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01739642
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  • 8
    Electronic Resource
    Electronic Resource
    Experimental neovascularization of the retina (1980)
    Springer
    International ophthalmology 2 (1980), S. 33-37 
    Details
    ISSN: 1573-2630
    Keywords: neovascularization ; retina ; fibroblasts ; intravitreal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intravitreal autotransplantation of tissue cultured rabbit skin fibroblasts results in neovascularization of the retina. Where proliferating fibroblasts reach the vascularized parts of the retina new capillaries arise and are clinically visible in at least 20% of the cases. The new vessels are shown to be immature by fluorescein angiography and electron microscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00149253
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  • 9
    Electronic Resource
    Electronic Resource
    Serum-induced collagen gel contraction (1995)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 233 (1995), S. 430-434 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract • Purpose: To understand the molecular events underlying disease-related vitreous gel contraction, the effect of serum components on collagen was investigated. • Methods: Bovine vitreous or dermal collagen was incubated with a mixture of transglutaminase (TG; factor XIIIa) and fibronectin (FN), and the biochemical changes of collagen were monitored by gel electrophoresis. In addition, serum-induced changes in the volume of the collagen gel were monitored. • Results: Gel electrophoresis revealed a new high-molecular-weight band (Mr 240 000) presumably due to intermolecular cross-links of collagen peptides and FN. The serum components also were shown to cause a significant decrease in the volume of the collagen gel. • Conclusion. Collagen gel contraction could be attributed to the collagen-FN-collagen cross-links catalyzed by TG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180947
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  • 10
    Electronic Resource
    Electronic Resource
    Novel polymorphisms in the βig-h3 gene (1998)
    Springer
    Journal of human genetics 43 (1998), S. 214-215 
    Details
    ISSN: 1435-232X
    Keywords: Key wordsβig-h3 gene ; Polymorphism ; Gelatinous drop-like corneal dystrophy ; Corneal dystrophy ; Linkage analysis ; Intragenetic marker
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We found three novel polymorphisms in the βig-h3 gene in patients with gelatinous drop-like corneal dystrophy: (1) a substitution from CTC to CTT at codon 472 that did not alter an amino acid; (2) a substitution from GCG (Ala) to GTG (Val) at codon 480; and (3) a substitution from C to T in intron 10, three nucleotides upstream from the acceptor site of exon 11. The allelic frequencies of the C : T polymorphism at codon 472 and in intron 10 in the Japanese population were estimated to be 0.778 : 0.222 and 0.954 : 0.046, respectively. Although the codon 480 substitution was not observed in 54 unrelated healthy Japanese people, the substation did not co-segregate with the disease phenotype, suggesting that this was a rare, non-deleterious alteration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380050075
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