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  • 1
    Electronic Resource
    Electronic Resource
    Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes (2000)
    [s.l.] : Nature America Inc.
    Nature genetics 24 (2000), S. 180-183 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Double-stranded RNA interference (RNAi) is an effective method for disrupting expression of specific genes in Caenorhabditis elegans and other organisms. Applications of this reverse-genetics tool, however, are somewhat restricted in nematodes because introduced dsRNA is not stably inherited. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/72850
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  • 2
    Electronic Resource
    Electronic Resource
    Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans (2002)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 419 (2002), S. 939-944 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Necrotic cell death underlies the pathology of numerous human neurodegenerative conditions. In the nematode Caenorhabditis elegans, gain-of-function mutations in specific ion channel genes such as the degenerin genes deg-1 and mec-4, the acetylcholine receptor channel subunit gene deg-3 and the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature01108
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  • 3
    Electronic Resource
    Electronic Resource
    eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans (2007)
    [s.l.] : Nature Publishing Group
    Nature 445 (2007), S. 922-926 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Regulation of protein synthesis is critical for cell growth and maintenance. Ageing in many organisms, including humans, is accompanied by marked alterations in both general and specific protein synthesis. Whether these alterations are simply a corollary of the ageing process or have a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature05603
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  • 4
    Electronic Resource
    Electronic Resource
    Genetic evidence for functional specificity of the yeast GCN2 kinase (1996)
    Springer
    Molecular genetics and genomics 251 (1996), S. 613-618 
    Details
    ISSN: 1617-4623
    Keywords: Key words GCN4 ; eIF-2 ; DAI kinase ; tRNA ; Translational regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  In yeast the GCN2 kinase mediates translational control of GCN4 by phosphorylating the α subunit of eIF-2 in response to extracellular amino acid limitation. Although phosphorylation of eIF-2α has been shown to inhibit global protein synthesis, amino acid starvation results in a specific activation effect on GCN4 mRNA translation. Under the same conditions, translation of other mRNAs appears only slightly affected. The mechanism responsible for the observed selectivity of the GCN2 kinase is not clear. Here, we present genetic evidence that suggests that locally restricted action of the GCN2 kinase facilitates GCN4-specific translational regulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02173652
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  • 5
    Electronic Resource
    Electronic Resource
    Transcriptional interference caused by GCN4 overexpression reveals multiple interactions mediating transcriptional activation (1995)
    Springer
    Molecular genetics and genomics 247 (1995), S. 571-578 
    Details
    ISSN: 1617-4623
    Keywords: Transcriptional squelching ; Adaptors ; TFIIB ; GCN5 ; ADA2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Overproduction of Gcn4p in yeast cells resulted in the inhibition of transcription from promoters controlled by the GAL4 or dA: dT elements. We have demonstrated that this effect is mediated through the activation domain of Gcn4p and that the function of the transcriptional activator at the affected promoter is impaired. The inhibitory effect of Gcn4p on these promoters persisted in yeast strains disrupted for the ADA2 and/or GCN5 genes, whose products are required for only part of the transcriptional activation capacity of Gcn4p and other activators, but was alleviated by overexpression of yTFIIB. These results support the hypothesis that general transcription factors become unavailable at certain promoters when an activator is overexpressed and strongly imply the existence of an Ada2p/Gcn5p-independent pathway of communication between acidic activators and the basic transcription machinery. In a genetic screen, we have isolated a mutation which neutralises the squelching effects of Gcn4p. This AFR1-1 (activation function reduced) mutation is dominant, it affects the transcriptional activation properties of a number of activators and results in lethality when combined with a gcn5 disruption. Our results suggest that the AFR1 gene product is involved in the mediation of transcriptional activation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00290348
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  • 6
    Electronic Resource
    Electronic Resource
    Sequence analysis of a 40·7 kb segment from the left arm of yeast chromosome X reveals 14 known genes and 13 new open reading frames including homologues of genes clustered on the right arm of chromosome XI (1996)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 12 (1996), S. 787-797 
    Details
    ISSN: 0749-503X
    Keywords: genome sequencing ; Saccharomyces cerevisiae ; chromosome X ; VPS35 ; INO1 ; SnR128 ; SnR190 ; MP12 ; YAK1 ; RPB4 ; YUR1 ; TIF2 ; MRS3 ; URA2 ; RSP25 homologue ; leucine zippers ; membrane proteins ; glycogenin glycosyltransferase ; human phospholipase D ; chromosome XI ; gene cluster translocation/recombination ; Life Sciences ; Life Sciences (general)
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The complete nucleotide sequence of a 40·7 kb segment about 130 kb from the left end of chromosome X of Saccharomyces cerevisiae was determined from two overlapping cosmids. Computer analysis of that sequence revealed the presence of the previously known genes VPS35, INO1, SnR128, SnR190, MP12, YAK1, RPB4, YUR1, TIF2, MRS3 and URA2, three previously sequenced open reading frames (ORFs) of unknown function 5′ of the INO1, 5′ of the MP12 and 3′ of the URA2 genes and 13 newly identified ORFs. One of the new ORFs is homologous to mammalian glycogenin glycosyltransferases and another has similarities to the human phospholipase D. Some others contain potential transmembrane regions or leucine zipper motifs. The existence of yeast expressed sequence tags for some of the newly identified ORFs indicates that they are transcribed. A cluster of six genes within 10 kb (YUR1, TIF2, two new ORFs, an RSP25 homologue and MRS3) have homologues arranged similarly within 28·5 kb on the right arm of chromosome XI. The sequence has been deposited in the EMBL data library under Accession Number X87371.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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