ISSN:
1432-1130
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract An analytical method has been developed which allows the determination of 22 different neutral and weakly basic drugs belonging to several different medicinal classes like antiphlogistics, betablockers, β2-sympathomimetics, lipid regulators, antiepileptic agents, psychiatric drugs and vasodilators in waste water as well as in river and drinking water. A method including solid phase extraction, derivatization by silylation and detection by GC/MS permits detection down to 5 ng/L. The recovery rates mostly exceeded 70%. However, the determination of phenazone, carbamazepine, cyclophosphamide, ifosfamide and pentoxiphylline is frequently disturbed by organic co-extractants in real samples of rivers and waste waters. Therefore, a time saving alternative method has been developed, combining solid phase extraction (as an enrichment step) together with detection by LC-electrospray/MS/MS allowing the measurement of 5 neutral drugs. Detection limits down to 10 ng/L have been achieved even for organically highly contaminated waters like sewage treatment plant effluents.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002160051083
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