ISSN:
1435-4373
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract This study was undertaken to characterize the epidemiology and clinical presentation of infection withChlamydia pneumoniae in a population composed primarily of middle-aged and older adults. Pharyngeal swabs and acute and convalescent phase sera were obtained from outpatients presenting with signs and symptoms of an acute respiratory infection. Sera were examined using the micro-immunofluorescence (MIF) test to detect antibody toChlamydia pneumoniae and complement fixation tests to detectMycoplasma pneumoniae, influenza A virus, influenza B virus, respiratory syncytial virus and adenovirus. Pharyngeal swab specimens were cultured forChlamydia pneumoniae and tested forChlamydia pneumoniae by the polymerase chain reaction (PCR). A total of 743 patients with a mean age of 40.5 ± 16.1 years were enrolled in the study. Twenty-one patients were serologically positive for acuteChlamydia pneumoniae infection in the MIF test. PCR was positive in 15 of the 20 serologically positive patients tested. AcuteChlamydia pneumoniae infection was identified in 3 % (2/76) of subjects with pneumonia, 5 % (12/247) of those with bronchitis, 5 % (3/61) of those with sinusitis only and 2 % (2/103) of those with pharyngitis only. Of the 21 patients withChlamydia pneumoniae infection, seven (mean age of 33 years) had an antibody pattern suggesting a primary infection while 14 (mean age of 54 years) had a reinfection pattern. Patients with reinfection had milder disease than those with primary infection. PCR testing in the current study confirms the previously proposed serologic criteria of acuteChlamydia pneumoniae infection.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02111337
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