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  • 1
    Electronic Resource
    Electronic Resource
    A separation chamber to sort cells and cell organelles by weak physical forces - III. Preparative electrophoresis of cells in stationary density gradients at low electric field strength
    Amsterdam : Elsevier
    Analytical Biochemistry 124 (1982), S. 432-439 
    Details
    ISSN: 0003-2697
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-2697(82)90061-6
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  • 2
    Electronic Resource
    Electronic Resource
    The flow of concentrated surfactant solutions through narrow capillaries (2000)
    Springer
    Colloid & polymer science 278 (2000), S. 418-424 
    Details
    ISSN: 1435-1536
    Keywords: Key words Microfiltration ; Admicelle mobility ; Micellar solutions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  The resistance of microfilters in a flow of micellar solutions indicates that the surfactant which is adsorbed in the pores forms a mobile admicelle. The flow in these admicelles can be stopped by Marangoni forces if there is a concentration gradient of surfactant across the filter. On the basis of thermodynamic concepts and experimental data it is argued that the resistance of the filters could be affected by shear-induced surfactant adsorption. To minimize the entropy production in the flow through a narrow pore the micellar solution separates into parallel fluxes of liquid through the lumen of the pore and of mobile surfactant in the flowing admicelle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003960050534
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Glucosylation of flavonoids in petals of Petunia hybrida (1981)
    Springer
    Planta 153 (1981), S. 459-461 
    Details
    ISSN: 1432-2048
    Keywords: Anthocyanin ; Flavonoid ; Glucosylation (flavonoids) ; Petunia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract During the biosynthesis of anthocyanins in Petunia hybrida, the 3-hydroxyl group is glucosylated. Their supposed biosynthetic precursors, the dihydroflavonols, are glucosylated at the 7 or 4′ positions. The question arose of whether these glucosides or the aglucones act as a substrate in anthocyanin synthesis. Using isolated flower buds of white flowering mutants that were blocked in an earlier step of biosynthesis, it was found that anthocyanin-3-glucosides and dihydroquercetin-7-glucoside were synthesized if dihydroquercetin, dihydroquercetin-7-glucoside, or dihydroquercetin-4′-glucoside were used as precursors in these experiments. Intracellular dihydroquercetin-glucosides were not used as a substrate for anthocyanin synthesis. The results are explained by deglucosylation of dihydroquercetin-glucosides during uptake by isolated flower limbs. Dihydroquercetin-7-glucoside, formed intracellularly, is not available as a precursor for anthocyanins. We conclude that the aglucone form of dihydroquercetin acts as a substrate in anthocyanin biosynthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00394986
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  • 4
    Electronic Resource
    Electronic Resource
    The pharmacokinetics of amygdalin (1982)
    Springer
    Archives of toxicology 49 (1982), S. 311-319 
    Details
    ISSN: 1432-0738
    Keywords: Amygdalin ; Prunasin ; Diatrizoate ; Pharmacokinetics ; Intestinal absorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Amygdalin (d-mandelonitrile-β-d-gentiobioside) is a cyanogenic glycoside claimed to show anti-cancer activity, sold under the incorrect name “Laetrile”. For a sensible discussion of its alleged activity and its established toxicity it is necessary that its fate in the organism is known. The pharmacokinetics of amygdalin have been investigated in the Beagle dog after both intravenous and oral administration. The excretion of amygdalin has also been studied in the rat. Amygdalin concentrations were determined by high performance liquid chromatography in plasma ultrafiltrate and urine. The pharmacokinetics of amygdalin after intravenous administration were compared with those of diatrizoate, a model substance for extracellular volume and glomerular filtration. The amygdalin clearance is significantly larger than that of diatrizoate. The volumes of distribution of both substance are the same. After oral administration only a few percents of the amygdalin dose are systemically available. A part of the oral dose is recovered from the urine as prunasin (d-mandelonitrile-β-d-glucoside).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00347879
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of clofibric and beclobric acid in rat and monkey hepatocyte primary culture: influence on peroxisomal and mitochondrial β-oxidation and the activity of catalase, glutathione S-transferase and glutathione peroxidase (1994)
    Springer
    Archives of toxicology 68 (1994), S. 506-511 
    Details
    ISSN: 1432-0738
    Keywords: Key words: Peroxisome proliferators – Rat and monkey hepatocyte cultures – Antioxidant enzyme activities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The effect of hypolipidaemic compounds on peroxisomal fatty acid β-oxidation and on peroxisome morphology in the liver differs widely between rodent and primate species. We studied the relative importance of peroxisomal and mitochondrial β-oxidation of palmitate in primary cultures of hepatocytes isolated from rat and monkey liver in the absence or presence of clofibric acid or beclobric acid. It was demonstrated that it is possible to differentiate between peroxisomal and mitochondrial β-oxidation activities in intact cells. Overall β-oxidation of palmitate was ca. 30% higher in rat hepatocytes than in monkey liver cells. In both monkey and rat cell cultures the mitochondrial component was over 90% of the total palmitate β-oxidation. In rat hepatocyte culture clofibric acid and beclobric acid caused a 5- to 8-fold stimulation of peroxisomal β-oxidation, while in monkey cells this activity was not significantly increased. However, in cells derived from both species mitochondrial palmitate β-oxidation was increased (rat 2.5-fold; monkey 1.5-fold). These results indicate that the species differences in the increase in peroxisomal fatty acid oxidation are not a result of an inability to metabolize fatty acids in rat liver cell mitochondria. A comparison of the activity of enzymes involved in the detoxification of hydrogen peroxide showed that catalase and glutathione-S-transferase activity is 2.9-fold higher in monkey hepatocytes than in rat liver cells, while glutathione peroxidase activity was 1.6-fold higher in rat cells. When a comparison between both species is made for the ratio of hydrogen peroxide production over catalase activity, it can be concluded that this peroxide will have much smaller possibilities to escape from the peroxisomal compartment in monkey hepatocytes. These findings suggest that species differences in these enzyme activities can contribute to differences in susceptibility for peroxisome proliferator-induced carcinogenicity between rodents and primates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050103
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    The Pharmacokinetics of Amygdalin (1982)
    Springer
    Archives of toxicology 50 (1982), S. 313-313 
    Details
    ISSN: 1432-0738
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310863
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    Paper (German National Licenses)
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