ISSN:
1432-0533
Keywords:
Neuron-specific β-tubulin
;
TUJ1 monoclonal antibody
;
Pituitary gland
;
Pituitary adenoma
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Pituitary adenomas surgically resected from 61 consecutive patients and 9 normal pituitary glands were studied by immunohistochemistry to determine the localization of the class IIIβ-tubulin isotype (neuron-specific) which is recognized by the monoclonal antibody TUJ1. In normal pituitary glands only a few cells were weakly immunopositive for TUJ1, whereas, in 43(73%) of 61 adenomas, more than 5% of tumor cells were immunopositive. The result may indicate that this neuron-specific β-tubulin isotype may be either expressed de novo or enhanced under the transformation of pituitary acinar cells to tumors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00228589
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