Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Clinica Chimica Acta 108 (1980), S. 355-360 
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Polyneuropathie ; Enzephalopathie ; Organische Lösungsmittel ; Berufskrankheit ; Key words Polyneuropathy ; Encephalopathy ; Organic solvents ; Occupational disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Solvent induced polyneuropathy and encephalopathy have been acknowledged quite recently as occupational diseases in Germany. For compensation first of all the diagnosis has to be proven. For differential diagnosis other known causes as well as non-organic mental diseases must be taken into consideration. The causality between proven exposures and diagnosed disease has at least to be probable. To evaluate causation extensive experience of the experts is needed. In this context scientific criteria regarding neurotoxicity of the solvent, duration of exposure, individual aspects of non-occupational influences, time course of the disease are important within a thorough synoptic evaluation. Possibilities and limitations of sensitive diagnostic measures such as neurographic, neuropsychologic and neuroimaging examinations are discussed. The prognosis of toxic polyneuropathy and encephalopathy is in general favorable if exposure has stopped. Additionally, adequate therapy and rehabilitation measures are supportive for a good prognosis.
    Notes: Zusammenfassung Polyneuropathie und Enzephalopathie sind seit kurzem als Berufskrankheit (BK 1317) zu entschädigen, wenn sie durch organische Lösungsmittel oder Lösungsmittelgemische am Arbeitsplatz verursacht worden sind. Medizinische Voraussetzung ist die Diagnose der Polyneuropathie oder Enzephalopathie sowie deren differentialdiagnostische Abgrenzung gegenüber anderen organischen Ursachen sowie – im Falle der Enzephalopathie – gegenüber andersartigen psychischen Störungen, z.B. depressiven Störungen oder Somatisierungsstörungen. Die Beurteilung des Ursachenzusammenhanges zwischen Einwirkungen am Arbeitsplatz einerseits und der Erkrankungen andererseits ist schwierig und erfordert besondere Erfahrungen von seiten der Gutachter. Im Rahmen des interdisziplinären Vorgehens müssen zahlreiche internistische und neuropsychiatrische Differentialdiagnosen berücksichtigt werden. Die gesicherten arbeitsmedizinisch-neurotoxikologischen Kriterien, die für und gegen einen Ursachenzusammenhang sprechen, sind im Einzelfall umfassend zu prüfen. Möglichkeiten und Grenzen moderner diagnostischer Verfahren (Neurophysiologie, Neuropsychologie, bildgebender Methoden) sind bei der Kausalanalyse zu beachten. Für die Prognose sind die Beendigung der ursächlichen Expositionen und Maßnahmen der Rehabilitation entscheidend. Die Berufskrankheit ist im Einzelfall entsprechend der dadurch ausgelösten Minderung der Erwerbsfähigkeit zu entschädigen.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 42 (1978), S. 31-40 
    ISSN: 1432-1246
    Keywords: Biochemical investigations ; Conduction velocity measurements ; Trichloroethylene ; Chronically exposed collective ; Biochemische Untersuchungen ; Nervenleitgeschwindigkeitsmessungen ; Trichloräthylen ; chronisch exponiertes Kollektiv
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Sieben Personen, die chronisch gegenüber Trichloräthylen exponiert sind, wurden untersucht. Neben den Analysen im biologischen Material und arbeitsplatzbezogenen Raumluft-Messungen wurde die Nervenleitgeschwindigkeit (NLG) des N. ulnaris und N. radialis bestimmt. Im Blut analysierten wir die Konzentration von Trichloräthylen (TRI), Trichloräthanol (TCE) und Trichloressigsäure (TCA) und im Urin die Exkretion von WE und TCA. Durch die quantitative Erfassung der externen und internen Dosis wind die Halogenkohlenwasserstoff-Belastung arbeitsmedizinisch beurteilt. Bei einem Vergleichskollektiv von 13 Probanden, die eine ähnliche Altersverteilung zeigten, aber nicht Lösungsmittel-exponiert waxen, wurden die minimalen und maximalen Leitgeschwindigkeiten der betreffenden Nerven gemessen. Die erhaltenen Nervenleitgeschwindigkeiten stimmen für beide Kollektive mit den altersspezifischen Angaben in der Literatur überein. Zwischen den belasteten und nicht belasteten Personen ließ sich kein statistisch signifikanter Unterschied der Nervenleitgeschwindigkeit sichern. Eine Korrelation zwischen den biochemischen Parametern und den Nervenleitgeschwindigkeiten konnte nicht aufgezeigt werden.
    Notes: Summary The maximal and minimal conduction velocities of the Ulnar and Median Nerves of 7 persons, chronically exposed to trichloroethylene (TRI), were measured. To evaluate the solvent's load we analysed the biological material and the trichloroethylene-concentration in air at the working place. The amount of trichloroethylene, trichloroethanol (TCE) and trichloroacetic acid (TCA) in blood was determined as well as the excretion of TCE and TCA in urine. By the determination of the external and internal dosis the halogenated hydrocarbon load is commentable in occupational medicine. Additionally the conduction velocity of the corresponding nerves of a control group of 13 persons was measured which had a similar distribution of age, but which was not exposed to that solvent. Our results for both collectives agreed with the age-corresponding values given in the literature. There was no statistically significant difference between the exposed and non-exposed persons. Further no correlation between the biochemical parameters and the conduction velocity could be proved.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 64 (1992), S. 353-359 
    ISSN: 1432-1246
    Keywords: Neurotoxicity ; Organic solvents ; Spray painters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A multidisciplinary cross-sectional study was carried out in 105 spray painters with long-term solvent exposure (10–44 years) and in 58 control subjects not exposed to solvents. By means of air monitoring the solvent concentrations in the ambient air during spray painting were determined using charcoal and silicagel tubes with pumps and passive samplers. In general, the air concentrations of the individual compounds did not exceed the current limit values (MAK values). Aromatic hydrocarbons like toluene, xylene, ethylbenzene, trimethylbenzene, aliphatic hydrocarbons (e.g., heptane) and acetates (ethylacetate, butylacetate) were determined to be important components of paint solvents. However, in unfavorable work conditions the “exposure index” could exceed the permissible limits two or three times. To assess the body solvent load at the time of examination, biological monitoring (BM) was performed. The main finding was that there was no evidence of neuro-toxicologically relevant solvent exposure. Only in the case of methyl hippuric acid in urine spot samples did the spray painters show a higher mean value (80 mg/l) than control subjects (below 20 mg/l), indicating recent xylene exposure. Elevated urinary chromium concentrations (maximum value 29 μg/l) were found in 28 spray painters as a result of using zinc chromate-containing wash primers without taking protective measures. To assess the degree of past solvent exposure a special questionnaire was used. This included variables like duration and amount of solvent exposure, the presence of a technical ventilation system, health complaints during painting, etc. Additionally, three “solvent exposure indices” (SEI) were calculated and used for evaluation of “dose-effect relationships.” In summary, the responses to the questionnaire did not show a characteristic pattern of symptoms. The frequency of symptoms is more likely to be determined by age than by chronic solvent exposure. Health complaints like increased tiredness, deterioration in short-term memory, and headache were equally frequent in spray painters and controls. In correlation analyses no hints of a dose-response relationship could be found.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 64 (1992), S. 361-372 
    ISSN: 1432-1246
    Keywords: Neurotoxicity ; Organic solvents ; Spray painters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A multidisciplinary cross-sectional study was performed to examine the chronic neurotoxicity of organic solvents. Participating in the study were 105 persons employed as spray painters and having long-term solvent exposure (10–44 years) and a control group consisting of 58 construction workers, electricians, and plumbers without occupational contact to solvents. Samples were matched for age, preexposure intelligence level, occupation, and socioeconomic status. After controlling for potentially non occupational confounding factors (neuropsychiatric diseases, metabolic disorders, high blood pressure, alcohol intake) 83 spray painters and 42 controls were entered finally into the study. The evaluation included work history, self-rating questionnaire, neurologic investigation, psychiatric analysis using the Present State Examination (PSE), psychological testing, and computerized axial tomography (CAT) of the brain. Physical and neurologic examinations demonstrated no case of overt disorders of the central or peripheral nervous system. An important result of the psychiatric analysis was that the syndromes “special features of depression” and “loss of interest and concentration” occurred significantly more frequently among spray painters than among controls. Further analyses demonstrated an association with chronic exposure over 30 years and repeated acute neurotoxic effects during solvent exposures. Neither psychological nor performance tests demonstrated any statistically significant differences in the performance sets after adjustment according to premorbid intelligence level; this finding supports the presumption of only a low grade of mental dysfunction. Correlation analyses indicated a relationship between subjective health complaints and long-term solvent exposure; however, the effect of age cannot be completely ruled out. Visual evaluation of CAT scans of the brain demonstrated significantly higher values for spray painters on the Cella media index, a measure of the inner liquor system of the brain. None of the other CAT parameters of inner or external brain atrophy showed significant differences. The rate of diffuse cerebral atrophy was not increased in spray painters. No statistical relationship between the solvent exposure index and CAT parameters was found by correlation analysis. In summary, the results do not support the hypothesis of an increased risk of solvent-induced encephalopathy among spray painters. It is not possible to establish a typical picture of central nervous system dysfunction due to chronic solvent exposure. Differences in the frequency of PSE symptoms “special features of depression” and “loss of interest and concentration” could be considered solvent related only if long-term (on average 30-year) exposure in combination with repeated acute neurotic effects had occurred. Cerebral atrophy beyond that of normal aging was not found in long-term exposed spray painters.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1432-1246
    Keywords: Key words Painters ; Organic solvents ; Neurotoxicity ; Symptoms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: The main aim of the study was to examine possible solvent-associated effects on the nervous system in currently employed painters. Special attention was paid to evaluate subtle health effects. Materials and methods: A total of 401 painters and 209 construction workers without solvent exposure with at least 10 years of professional experience were subjected to a clinical, neurological, psychiatric, neuropsychological and neurophysiological examination. For personal medical and occupational history, standardized questionnaires were used. A quantitative rating of exposure was obtained by expert rating of the respective occupational history without knowledge of the individual test results. Results: There was no excess of somatic disorders or solvent-associated adverse effects on the nervous system. No distinct effects of solvent exposure on nerve conduction velocities (NCV) or cognition were found. Discrete NCV deficits in painters were not considered a sign of subclinical polyneuropathy. Painters, however, reported an excess of specific symptoms that could be assigned to “mood and behaviour”. The differences between specific and non-specific questionnaire outcomes on the one hand and the positive correlation between chronic exposure index and symptom scores on the other hand support the hypothesis of solvent-induced effects. Because data is lacking on past solvent exposure, it is not possible to relate these effects to current exposure limits. Conclusions: Currently employed painters differ from controls not exposed to solvents with respect to the frequency of certain symptoms in mood and behaviour. These symptoms are related to life-long solvent exposure rather than to current exposure. At present, the issue of time course and reversibility or irreversibility of these symptoms cannot be answered. The predictive value for subsequent neuropsychiatric morbidity remains to be elucidated in follow-up studies.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 72 (1999), S. 521-527 
    ISSN: 1432-1246
    Keywords: Key words Manganese ; Biomonitoring ; Ambient air monitoring ; Hair analysis ; Dry cell manufacturing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: A cross-sectional study was carried out on 100 workers from three different workplace areas in a dry cell battery manufacturing plant and on 17 currently nonexposed referents, to examine the relationship between the external exposure to manganese dioxide (MnO2) and the body burden of manganese in blood, urine and hair. Methods: Inhalable dust was measured gravimetrically after stationary active sampling. Manganese was analyzed in dust samples, blood, urine and axillary hair by atomic absorption spectro- metry. Results: The average air concentrations of manganese in the three workplace areas were 4 μg/m3 (range: 1–12 μg/m3), 40 μg/m3 (12–64 μg/m3) and 400 μg/m3 (137–794 μg/m3). Manganese in blood and axillary hair correlated with airborne manganese in group-based calculations but not on an individual level. The manganese concentrations varied between 3.2 μg/l and 25.8 μg/l in the blood (mean: 12.2 ± 4.8 μg/l) and between 0.4 μg/g and 49.6 μg/g in hair (mean: 6.2 ± 6.2 μg/g in the proximal sequence), respectively. The results for the nonexposed referents were 7.5 ± 2.7 μg/l (mean) in the blood (range: 2.6–15.1 μg/l) and 2.2 ± 1.8 μg/g (mean) in axillary hair (range: 0.4–6.2 μg/g). In these matrices, manganese differed significantly between the highly exposed workers and both the reference and the low-exposure group. Manganese in blood revealed the lowest background variance. No differences for manganese in urine were observed between workers (mean: 0.36 ± 0.42 μg/l, range: 0.1–2.2 μg/l) and referents (mean: 0.46 ± 0.47 μg/l, range: 0.1–1.7 μg/l). Conclusions: Manganese in blood is a specific and suitable parameter for the biomonitoring of MnO2 exposure, although its validity is limited to group-based calculations. Urinary manganese failed to allow a differentiation between exposed workers and referents. The suitability of manganese analysis in hair for biomonitoring purposes suffers from a relatively great background variation as well as from analytical problems.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 73 (2000), S. 361-361 
    ISSN: 1432-1246
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 42 (1978), S. 129-135 
    ISSN: 1432-1246
    Keywords: 1.1.2-Trichloro-1.2.2-trifluoroethane ; External-internal dose ; Occupational exposure ; 1,1,2-Trichlor-1,2,2-trifluoräthan ; externe-interne Dosis ; berufliche Exposition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Rahmen einer arbeitsmedizinischen Studie wurden 10 Frauen und 3 Männer untersucht, die beruflich gegenüber dem Halogenkohlenwasserstoff 1,1,2-Trichlor-1,2,2-trifluoräthan (Frigen R 113) kurzfristig exponiert waren. Neben der Durchfürhrung von Erstuntersuchungen nach den Bestimmungen der Berufsgenossenschaftlichen Grundsätze erfolgte die quantitative Bestimmung der externen und internen Dosis des Halogenkohlenwasserstoffes. Die Analyse von 1,2,2-Trichlor-1,2,2-trifluoräthan in der Raum- und Ausatemluft führten wir infrarotspektrometrisch durch. Die Raumluftkonzentrationen schwankten von Tag zu Tag zwischen ca. 13 and 111 ppm. Zur Ermittlung der internen Dosis wurden die Serumproben gaschromatographisch untersucht. Die Halogenkohlenwasserstoff-Konzentrationen bewegten sich fur die länger belasteten Arbeiterinnen zwischen 3,15 und 9,75 mg/l und für die weniger stark exponierten Männer zwischen 1,20 und 4,85 mg/l. In der Ausatemluft fanden sich Lösungsmittelkonzentrationen zwischen 1,0 and 33,8 ppm am Ende der täglichen Exposition. Die Auswertung der klinisch-chemischen Parameter ergab keinen Hinweis für Lösungsmittel-bedingte adverse Effekte.
    Notes: Summary 10 women and 3 men, occupationally exposed to the halogenated hydrocarbon 1.1.2-trichloro-1.2.2-trifluoroethane (Frigen R 113) were examined. Additionally to the performance of the ‘Primary Examinations’ (‚Erstuntersuchungen’) concerning the specifications of the Berufsgenossenschaftlichen Grundsätze’ the external and internal dose of the solvent was quantitatively determined. 1.1.2-trichloro-1.2.2-trifluoroethane in the air at the working place and in exhaled air was analysed by infrared-spectrometry. The concentration in the air at the working place varied from day to day between about 13 and 111 ppm. The serum samples were analyzed gaschromatographically to determine the internal dose. The halogenated hydrocarbon concentrations ranged between 3.15 and 9.75 mg/l in women and between 1.20 and 4.85 mg/l in men who were less exposed than the women. At the end of the daily exposure the solvent concentration in exhaled air was between 1.0 and 33.8 ppm. The evaluation of the clinical-chemical parameters showed no indication of solvent caused adverse effects.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 61 (1989), S. 423-424 
    ISSN: 1432-1246
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...