ISSN:
1569-8041
Keywords:
intermittent androgen suppression
;
prostate cancer
;
prostate specific-antigen
;
testosterone
;
tissue polypeptide-specific antigen
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Background:In an intermittent androgen suppression therapy (IAS)trial we observed regular cycles of tumor suppression and regrowth in themajority of patients (17 ± 2.6 month), with a subpopulation of patients(14 of 72) exhibiting a prolonged response of 28 ± 7 month (range18–64+ month) to the first eight-month androgen suppression cycle. Purpose:To compare clinical data and laboratory tests(testosterone, prostate-specific antigen, and tissue polypeptide-specificantigen) of matched IAS patients showing either regular treatment cycles(n= 16) or prolonged response (n= 14). Results:Periods of androgen suppression resulted in reversiblereduction of serum testosterone (〈1 nmol/l), PSA (〈1 ng/ml) indicatingpartial growth arrest and apoptotic regression of the tumors. The long-termresponse subgroup showed significantly lower mean values of tumor gradings,of pretreatment PSA values (11.36 ± 4.54 vs. 47.5 ± 12.4 ng/mlPSA), of PSA nadirs during androgen suppression (0.5 vs. 1 ng/ml PSA), and ofoverall testosterone values (3.9 ± 1.14 vs. 6.6 ± 1.18 mmol/lpretreatment) associated with low TPS values. Conclusions:Patients exhibiting prolonged response to a singlecycle of androgen suppression during IAS are characterized by a lower tumorburden, slow growing and less agressive tumors, lower testosterone serumconcentrations and lower absolute PSA nadirs during androgen suppressioncompared to a matched control group of short-term responders.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008347801886
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