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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 27 (1995), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The clinicopathological features of nine cases of recurrent thymomas have been studied. At presentation, all cases were histologically classified as thymomas with cortical differentiation, including predominantly cortical thymoma, cortical thymoma and well-differentiated thymic carcinoma. In five cases the morphological features of the recurrence(s) were suggestive of a histological progression of the tumour from predominantly cortical thymoma to cortical thymoma and/or well-differentiated thymic carcinoma, usually associated with a more advanced clinical stage, the latter indicating a clinical progression. These findings suggest that all types of thymoma with cortical differentiation are histologically and histogenetically related neoplasms, associated with a more aggressive clinical behaviour and a significant risk of recurrence. The overall outcome of patients with recurrent thymoma in this series was poor, since six patients (66.6%) died due to the disease, 2–14 years after the first diagnosis. The clinical implication of our findings is that thymomas with cortical differentiation always need careful follow-up, even in those cases which are not obviously invasive at onset.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 20 (1992), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Twenty cases of macroscopically non-neoplastic thymuses obtained from patients with myasthenia gravis have been studied histologically. Seven cases were characterized by lymphoid follicular hyperplasia and 13 by involutional changes of variable degree. In three cases (15%), one with lymphoid follicular hyperplasia and two with involutional changes, multiple microscopic epithelial lesions, 0.2–0.4 mm in diameter and consistent with foci of microscopic thymoma, were observed. Most of them were related to the thymic cortex and one, displaying a different histological pattern, was located in a medullary area. These observations provide morphological evidence of a possible multifocal origin of thymoma from distinct epithelial clones present in the different topographic areas of the human thymus.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Clinical Anatomy 5 (1992), S. 16-24 
    ISSN: 0897-3806
    Keywords: morphology ; bile duct ; duodenal wall ; Life and Medical Sciences ; Miscellaneous Medical
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The precise morphology of the human sphincter of Oddi was investigated. Anatomic samples, including the terminal portion of the bile duct and main pancreatic ducts, the major duodenal papilla, and the periampullary duodenal wall, were removed from 22 cadavers of various ages of patients who had died without any history of biliary or pancreatic disease.The specimens were fixed and processed by routine techniques and examined by light microscopy; serial sections were stained with haematoxylin-eosin, Masson's trichrome, and Van Gieson methods.The muscular bundles of the human sphincter of Oddi were divided into the following tracts: The X-Y tract, the distance from the papillary opening to the first muscular thickening that showed a circular trend; the Y-Z tract, the thickest portion of the circular muscular bundles (the true sphincter of the hepatopancreatic ampulla( (HPA) (Oddi), reinforced by fibres arising from the duodenal wall and the Z-W tract, the terminal thinner portion of the circular bundles that pass from the duodenal wall to the bile duct. The X′, Y′, Z′, and W′ points were fixed by the same criteria along the wall of the main pancreatic duct.The single tracts were measured, and the data derived therefrom subjected to statistical analysis.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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