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  • 1
    Electronic Resource
    Electronic Resource
    Insulin resistance as cause of increased blood pressure in the elderly: effects on intracellular ion contents
    Amsterdam : Elsevier
    Archives of Gerontology and Geriatrics 11 (1990), S. 23-32 
    Details
    ISSN: 0167-4943
    Keywords: Blood pressure ; Cell cation content ; Elderly ; Insulin resistance
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4943(90)90053-9
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The combined insulin and sulfonylurea therapy in diabetes of elderly people
    Amsterdam : Elsevier
    Archives of Gerontology and Geriatrics 13 (1991), S. 245-253 
    Details
    ISSN: 0167-4943
    Keywords: Combination therapy ; Elderly diabetes ; Insulin-gliclazide ; Secondary failure
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4943(91)90046-S
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Glucose intolerance in the elderly: an open debate
    Amsterdam : Elsevier
    Archives of Gerontology and Geriatrics 11 (1990), S. 125-132 
    Details
    ISSN: 0167-4943
    Keywords: Aging ; Environmental factors ; Glucose intolerance ; Insulin secretion ; Insulin sensitivity
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4943(90)90004-P
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  • 4
    Electronic Resource
    Electronic Resource
    Exaggerated orthostatic hypotension as first sign of diabetic autonomic neuropathy in the elderly
    Amsterdam : Elsevier
    Archives of Gerontology and Geriatrics 9 (1989), S. 107-113 
    Details
    ISSN: 0167-4943
    Keywords: Autonomic neuropathy ; Cardiovascular functions ; Diabetes mellitus ; Elderly
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4943(89)90031-9
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Changes in glucose turnover parameters during muscular exercise: role of age
    Amsterdam : Elsevier
    Archives of Gerontology and Geriatrics 10 (1990), S. 253-260 
    Details
    ISSN: 0167-4943
    Keywords: Euglycaemic clamp ; Glucose turnover parameters ; Muscular exercise ; Oral glucose tolerance test
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4943(90)90026-3
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  • 6
    Electronic Resource
    Electronic Resource
    Impaired insulin-induced erythrocyte magnesium accumulation is correlated to impaired insulin-mediated glucose disposal in Type 2 (non-insulin-dependent) diabetic patients (1988)
    Springer
    Diabetologia 31 (1988), S. 910-915 
    Details
    ISSN: 1432-0428
    Keywords: Erythrocyte ; Type 2 (non-insulin-dependent) diabetes ; insulin ; insulin-resistance ; magnesium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma and erythrocyte magnesium levels were measured by atomic absorption spectrometry in 12 healthy subjects and 12 moderately obese patients with Type 2 (non-insulin-dependent) diabetes mellitus. Basal plasma and erythrocyte magnesium levels were significantly lower in diabetic patients than in control subjects. In vitro incubation in the presence of 100 mU/l insulin significantly increased magnesium erythrocyte levels in both control subjects (p〈0.001) and patients with diabetes (p〈0.001). However, even in the presence of 100mU/l insulin, the erythrocyte magnesium content of patients with Type 2 diabetes was lower than that of control subjects. The in vitro dose-response curve of the effect of insulin on magnesium erythrocyte accumulation was shifted to the right when red cells of diabetic patients were used, with a highly significant reduction of the maximal effect. Such reduction of the maximal effect of insulin suggests that the impairment of insulin-induced erythrocyte magnesium accumulation observed in Type 2 diabetic patients results essentially from a post-receptor defect. In the diabetic patients, the Δ increase in erythrocyte magnesium levels (calculated as the net increase between basal and 100 mU/l insulin-induced erythrocyte magnesium levels) was negatively correlated with plasma insulin levels (r=−0.86; p〈0.001) and with body mass index (r=−0.90; p〈0.001); it was positively correlated with the glucose disappearance constant Kg after intravenous glucose injection (r=0.79; p〈0.01), with the amount of glucose required to keep euglycaemia despite hyperinsulinaemia in a glucose clamp (r=0.88; p〈0.001), and with the metabolic clearance rate of glucose during the clamp (r=0.82; p〈0.001). These results demonstrate that insulin-induced erythrocyte magnesium accumulation is impaired in patients with Type 2 diabetes and that such defect is correlated to impaired insulin-mediated glucose disposal in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265376
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  • 7
    Electronic Resource
    Electronic Resource
    Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects (1995)
    Springer
    Diabetologia 38 (1995), S. 1295-1299 
    Details
    ISSN: 1432-0428
    Keywords: Key words Non-esterified fatty acids ; plasma insulin ; acute insulin response ; respiratory quotient.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Our study investigates short- and long-term effects of infusion of non-esterified fatty acids (NEFA) on insulin secretion in healthy subjects. Twelve healthy individuals underwent a 24-h Intralipid (10 % triglyceride emulsion) infusion at a rate of 0.4 ml/min with a simultaneous infusion of heparin (a bolus of 200 U followed by 0.2 U/min per kg body weight). After an overnight fast (baseline), at 6 and at 24 h of Intralipid infusion and 24 h after Intralipid discontinuation (recovery test), all subjects underwent an intravenous glucose tolerance test (ivGTT) (25 g of glucose/min). Intralipid infusion caused a threefold rise in plasma NEFA concentrations with no difference between the 6- and the 24-h concentrations. Compared to baseline acute insulin response (AIR) (AIR = 63 ± 8 mU/l), short-term (6-h) Intralipid infusion was associated with a significant increase in AIR (86 ± 12 mU/l p 〈 0.01); in contrast, long-term (24-h) Intralipid delivery was associated with inhibition of AIR (31 ± 5 mU/l) compared to baseline (p 〈 0.001) and to the 6-h (p 〈 0.03) triglyceride emulsion infusion. Intralipid infusion was associated with a progressive and significant decline in respiratory quotient (RQ). A positive correlation between changes in fasting plasma NEFA concentrations and AIR at the 6-h infusion (r = 0.89 p 〈 0.001) was found. In contrast, at the end of the Intralipid infusion period, changes in plasma NEFA concentrations and AIR were negatively correlated (r = − 0.87 p 〈 0.001). The recovery test showed that fasting plasma NEFA concentrations, RQ and AIR had returned to baseline values. In the control study (n = 8) 0.9 % NaCl infusion did not mimick the effect of Intralipid. In conclusion, our study demonstrates that short- and long-term exposures of beta cells to high plasma NEFA concentrations have opposite effects on glucose-induced insulin secretion. [Diabetologia (1995) 38: 1295–1299]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401761
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  • 8
    Electronic Resource
    Electronic Resource
    Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects (1995)
    Springer
    Diabetologia 38 (1995), S. 1295-1299 
    Details
    ISSN: 1432-0428
    Keywords: Non-esterified fatty acids ; plasma insulin ; acute insulin response ; respiratory quotient
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Our study investigates short- and long-term effects of infusion of non-esterified fatty acids (NEFA) on insulin secretion in healthy subjects. Twelve healthy individuals underwent a 24-h Intralipid (10% triglyceride emulsion) infusion at a rate of 0.4 ml/min with a simultaneous infusion of heparin (a bolus of 200 U followed by 0.2 U/min per kg body weight). After an overnight fast (baseline), at 6 and at 24 h of Intralipid infusion and 24 h after Intralipid discontinuation (recovery test), all subjects underwent an intravenous glucose tolerance test (iv-GTT) (25 g of glucose/min). Intralipid infusion caused a threefold rise in plasma NEFA concentrations with no difference between the 6- and the 24-h concentrations. Compared to baseline acute insulin response (AIR) (AIR=63±8 mU/l), short-term (6-h) Intralipid infusion was associated with a significant increase in AIR (86±12 mU/l p〈0.01); in contrast, long-term (24-h) Intralipid delivery was associated with inhibition of AIR (31±5 mU/l) compared to baseline (p〈0.001) and to the 6-h (p〈0.03) triglyceride emulsion infusion. Intralipid infusion was associated with a progressive and significant decline in respiratory quotient (RQ). A positive correlation between changes in fasting plasma NEFA concentrations and AIR at the 6-h infusion (r=0.89 p〈0.001) was found. In contrast, at the end of the Intralipid infusion period, changes in plasma NEFA concentrations and AIR were negatively correlated (r=−0.87 p〈0.001). The recovery test showed that fasting plasma NEFA concentrations, RQ and AIR had returned to baseline values. In the control study (n=8) 0.9% NaCl infusion did not mimick the effect of Intralipid. In conclusion, our study demonstrates that short- and long-term exposures of beta cells to high plasma NEFA concentrations have opposite effects on glucose-induced insulin secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401761
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  • 9
    Electronic Resource
    Electronic Resource
    Pulsatile glucagon has greater hyperglycaemic, lipolytic and ketogenic effects than continuous hormone delivery in man: effect of age (1990)
    Springer
    Diabetologia 33 (1990), S. 272-277 
    Details
    ISSN: 1432-0428
    Keywords: Glucagon ; glycerol ; β-hydroxybutyrate ; ketogenesis ; lipolysis ; non esterified fatty acids ; pulsatility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present study aimed at investigating the hyperglycaemic, lipolytic and ketogenic effects of small doses of glucagon delivered continuously or in a pulsatile manner. The study was performed in eight healthy young volunteers (24.2±1.2 years) and in eight healthy aged subjects (69.4±2.0 years). In all the subjects, endogenous pancreatic hormone secretion was inhibited by somatostatin and only glucagon was replaced. Consequently, the effects of pulsatile and continuous glucagon delivery were studied in conditions of progressive somatostatin-induced insulin deficiency. In both the young and the aged subjects, pulsatile glucagon delivery resulted in increases in plasma glucose, non-esterified fatty acid, glycerol and β-hydroxybutyrate levels greater than those observed when the same amount of glucagon was delivered in a continuous manner. The net increases in plasma glucose, glycerol and non-esterified fatty acid levels were similar between the young and the aged subjects when glucagon was infused continuously; in contrast, the rise in plasma β-hydroxybutyrate in the aged was only about half that observed in the young subjects. Surprisingly, when glucagon was infused in a pulsatile manner, the rises in plasma glycerol, non-esterified fatty acid and β-hydroxybutyrate levels were all significantly smaller in the aged subjects, while no significant differences were observed in the blood glucose responses. We conclude that, in the presence of somatostatin-induced insulin deficiency, pulsatile glucagon exerts greater effects on blood glucose, plasma non-esterified fatty acid, glycerol and β-hydroxybutyrate levels than its continuous delivery. In the elderly, the lipolytic and ketogenic, but not the hyperglycaemic, responses to pulsatile glucagon are significantly reduced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403320
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of sparteine sulphate upon basal and nutrient-induced insulin and glucagon secretion in normal man (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 477-480 
    Details
    ISSN: 1432-1041
    Keywords: sparteine sulphate ; insulin ; glucagon/insulin secretion ; glucose tolerance test ; food interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Infusion of a therapeutic dose of sparteine sulphate, increased the basal plasma insulin level and lowered plasma glucose. When an intravenous glucose tolerance test was performed with the infusion, the total insulin AUC was significantly larger than in absence of sparteine (2025 vs 1464 µU/ml×min), plasma glucose levels were lower and improved glucose utilization was observed (kg:1.55 vs 1.39%). In the presence of arginine, sparteine sulphate stimulated both β and α cells, increasing both the total insulin (1907 vs 1516 µU/ml×minp〈0.02) and total glucagon AUCs (7616±654 vs 6789±707 pg/ml×minp〈0.01). Thus, sparteine sulphate increased both basal and nutrient-induced insulin and glucagon secretion in normal man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637673
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