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  • 1
    Electronic Resource
    Electronic Resource
    Estrogen Hormones Reduce Lipid Peroxidation in Cells and Tissues of the Central Nervous System (1999)
    Oxford UK : Blackwell Science Ltd.
    Journal of neurochemistry 72 (1999), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Effects of estrogen hormones on lipid peroxidation (LPO)were examined in rat brain homogenates (RBHs), hippocampal HT 22 cells, ratprimary neocortical cultures, and human brain homogenates (HBHs).Dose-response curves indicated half-maximal effective concentrations(EC50) of 5.5 and 5.6 mM for iron-induced LPO in RBHs andHT 22 homogenates. Incubation of living rat primary neocortical cultures withiron resulted in an EC50 of 0.5 mM, whereas culturehomogenates showed an EC50 of 1.2 mM. Estrogen hormonesreduced LPO in all systems: In RBHs, estrone inhibited iron-induced LPO to74.1 ± 5.8% of control levels (17β-estradiol: 71.3 ± 0.1%)at a concentration of 10 μM. In hippocampal HT 22 cellhomogenates, levels of LPO were reduced to 74.8 ± 5.5% by estrone andto 47.8 ± 6.2% by 17β-estradiol. In living neocortical cultures,17β-estradiol decreased iron-induced LPO to 79.2 ± 4.8% andincreased the survival of cultured neuronal cells. Of the other steroidcompounds tested (corticosterone, progesterone, testosterone), onlyprogesterone decreased LPO in HT 22 cell homogenates. In HBHs, LPO wasdose-dependently increased by iron concentrations from 2.7 to 6.0 mM.Incubation with estrogens resulted in a dose-dependent inhibition of LPO to53.89 ± 8.6% with 10 μM 17β-estradiol, whereas estrone failed to affect iron-induced LPO to a significant extent. Nonestrogenic steroids, including hydrocortisol, did not show significant effects on LPO in HBHs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1999.0722531.x
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  • 2
    Electronic Resource
    Electronic Resource
    The potential energy barrier of the Na2 B 1Πu state (1987)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 86 (1987), S. 3082-3088 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The technique of modulated gain spectroscopy has provided detailed information about the shape of the Na2 B 1Πu state potential barrier to dissociation. By measuring the rotation–vibration energies (to ±0.006 cm−1) of all (v'=27–33) quasibound vibrational levels and the rotation-dependent tunneling rates (as obtained from linewidth measurements) of the highest quasibound vibrational level, v'=33, we have been able to characterize this barrier. Our studies show that the barrier height is U(rmax,J=0)=375.2±3.9 cm−1, relative to the center of gravity of the Na(3s)+Na(3p) atomic limit, and the barrier maximum is located at rmax=6.85±0.02 A(ring).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.452019
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  • 3
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    Die Bergdama in Südwest-Afrika (1930)
    London : Periodicals Archive Online (PAO)
    Africa. 3:2 (1930) 178 
    Details
    ISSN: 0001-9720
    Topics: Ethnic Sciences , Political Science , Sociology
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4011-1930-003-02-000004
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  • 4
    Electronic Resource
    Electronic Resource
    Konzentrationen von Immunglobulinen, Alpha-1-Fetoprotein, Alpha-2-Makroglobulin, Albumin und Präalbumin im Fruchtwasser bei Risikoschwangerschaften (1981)
    Springer
    Archives of gynecology and obstetrics 232 (1981), S. 489-490 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02429660
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  • 5
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    The New Church History (1913)
    Philadelphia : Periodicals Archive Online (PAO)
    Social studies. 4:10 (1913:Dec.) 275 
    Details
    ISSN: 0037-7996
    Topics: History
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:3111-1913-004-10-000001
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  • 6
    Electronic Resource
    Electronic Resource
    Dose-dependence of bacterial lipopolysaccharide (LPS) effects on peak response and time course of the immune-endocrine host response in humans (1999)
    Springer
    Inflammation research 48 (1999), S. 67-74 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Lipopolysaccharide — Hormones — Cytokines — Cortisol — Neuro-immune-endocrine network
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: Dose-dependence of lipopolysaccharide (LPS) effects on peak and time course parameters of the immune-endocrine host response was examined in a placebo-controlled design.¶Subjects: Data from 42 male volunteers were included.¶Treatment: 0.4 or 0.8 ng LPS/kg body weight were applied at 7.00 p.m.¶Methods: Body temperature, heart rate and leukocyte counts were quantified. Plasma levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), adrenocorticotropic hormone (ACTH), cortisol and human growth hormone (hGH) were measured.¶Results: LPS increased significantly the levels of immune (TNF-α, IL-6) and endocrine (ACTH, cortisol) parameters. HGH secretion was advanced without changes in the total amount of hGH released. Dose-dependence of endotoxin's effects was significant for neuroendocrine (cortisol) and physiological (temperature, heart rate) parameters. Examination of time course parameters demonstrated that the higher dose of endotoxin prolonged the increases in temperature, IL-6 and cortisol levels.¶Conclusions: Our data show that increases in the dosage of LPS lead to differential peak responses and changed time course patterns of the human host response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050408
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  • 7
    Electronic Resource
    Electronic Resource
    High resolution molecular spectroscopy with lasers (1986)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 324 (1986), S. 479-485 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Summary Several sensitive detection techniques, such as excitation spectroscopy or resonant two-photon ionization spectroscopy are applied to laser spectroscopy with sub-Doppler resolution in collimated molecular beams. Due to internal cooling during the adiabatic expansion in supersonic beams rotational temperatures below 10 K can be reached which results in a drastic simplification of otherwise complex molecular spectra. Different schemes of optical-optical double resonance spectroscopy with two cw or pulsed narrow band lasers are discussed which allow the unambiguous assignment of perturbed molecular spectra. The techniques are illustrated by their application to NO2, SO2, Cs2 and to the study of Rydberg states of Li2.
    Notes: Zusammenfassung Empfindliche Nachweismethoden der Laserspektroskopie, wie z. B. die Anregungsspektroskopie oder die resonante Zweiphotonen-Ionisation werden angewandt auf die Doppler-freie Untersuchung kleiner Moleküle, wie NO2 und SO2 in kollimierten Überschallstrahlen. Durch die drastische Abkühlung bei der adiabatischen Expansion können Rotationstemperaturen unter 10 K erreicht werden, was die Liniendichte in den Spektren stark reduziert und damit die Analyse der Spektren wesentlich vereinfacht. Verschiedene Techniken der optischen-optischen Doppelresonanz-Spektroskopie mit zwei kontinuierlichen oder gepulsten Lasern werden illustriert am Beispiel der Untersuchung von Rydberg-Zuständen von Li2 und des langreichweitigen Potentials von Cs2. Der Vorteil dieser Techniken für die Analyse komplexer Molekülspektren wird diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00474120
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  • 8
    Electronic Resource
    Electronic Resource
    Die Rolle der Östrogene in der Prävention und Therapie von Demenzen (2000)
    Springer
    Reproduktionsmedizin 16 (2000), S. 310-318 
    Details
    ISSN: 1434-808X
    Keywords: Schlüsselwörter Alzheimer-Demenz • Risikofaktoren • Neuroprotektion •Östrogen • Therapie ; Keywords Alzheimer • Dementia • Risk factors •¶Neuroprotection • Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Estrogens induce a pleiotropy of relevant neuroprotective effects. They occur via actions on vascular factors, on the metabolism of toxic free radicals, on the cholinergic system and on growth factor systems. Beside this, estrogens affect neurocellular phosphorylation, antiapoptotic proteins and the metabolism of Alzheimer's disease-related proteins, partly mediated by their “classical genomic receptors” and partly by other mechanisms. The available clinical and epidemiological database however, reveals no relevant effects (except for some verbal functions) in already demented patients and on normal neuropsychological symptoms of ageing. Whether estrogen treatment in earlier periods (e. g. perimenopause) or the endogenous hormone production reduce the risk of dementia in later life, is not clear yet. Pathophysiological interactions of a variety of biological, psychological and social factors must be taken into account. The article defines questions to be solved.
    Notes: Zusammenfassung Östrogene induzieren eine Vielzahl von relevanten neuroprotektiven Wirkungen. So konnten bisher Effekte auf vaskuläre Funktionen, auf den Metabolismus freier Radikale, auf die Lipidperoxidation sowie auf cholinerge Parameter und Wachstumsfaktorsysteme beschrieben werden. Daneben werden intrazelluläre Phosphorylierungsprozesse, antiapoptotische Stoffwechselwege, sowie die Sekretion von Proteinen, die bei der Alzheimer-Erkrankung von Bedeutung sind, beeinflusst. Neben direkten Wirkungen werden viele Effekte durch „klassische Östrogenrezeptoren“über genomische Regulationsvorgänge vermittelt. Die vorliegenden klinischen und epidemiologischen Untersuchungen konnten einen relevanten therapeutischen Effekt auf bereits Demenzkranke nicht nachweisen, auch Effekte auf neuropsychologische Funktionen im normalen Alter ließen sich kaum zeigen, allenfalls auf sprachgebundene Leistungen. Die interessante Frage, inwieweit Hormongaben in früheren Lebensabschnitten oder endogene Hormonspiegel das Risiko für eine Demenzerkrankung verändern und somit präventive Effekte zu verzeichnen sind, kann noch nicht abschließend beantwortet werden. In der Übersicht werden mögliche Zusammenhänge und noch zu klärende Fragen dargestellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004440000207
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  • 9
    Electronic Resource
    Electronic Resource
    Das Rotationsschwingungsspektrum des Methans (1933)
    Springer
    The European physical journal 86 (1933), S. 137-156 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Zusammenfassung Photographiert wird im Gebieteλλ 10000 bis 7000 Å das Absorptionsspektrum des Methans mit Schichtdicken bis zu 20 m und mit Drucken bis 5 Atm. Zur Ausmessung gelangen 7 Banden beiλλ 9880, 9700, 8900, 8600, 8400, 7800, 7250. Zwar gelingt es nicht, die komplizierte Rotationsstruktur der Banden zu analysieren, doch kann eine Zuordnung der 23 bisher in Absorption gefundenen Banden und der drei Ramanfrequenzen zu den vier Normalschwingungen des Moleküls gegeben werden. Diese sindν (a)=3015-15ν;ν (s) = 2945-50 (νs+ νa;δ (a)=1320-15 (ν a +ν s );δ(s)=1530- 10 (ν a +ν s ). Eine Schwingungsberechnung zeigt, daß die Voraussetzungen des Valenzkraftsystems hier weitgehend erfüllt sind, indem sich die CH-Kräfte zu den Winkel- und den HH-Kräften verhalten wie 5,5 ∶ 1 ∶ 0,12.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01343281
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