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Irritancy testing of sodium laurate and other anionic detergents using an open exposure model (1997)

Tupker, R. A. ; Vermeulen, K. ; Fidler, V. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Skin research and technology 3 (1997), S. 0

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ISSN: 1600-0846

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: The irritant potency of soap (sodium laurate, LAU) as opposed to other anionic detergents is not uniformly agreed upon. The aim of the study was to compare the irritancy of sodium laurate with that of sodium laurylsulphate (SLS), sodium cocoyl isethionate and disodium lauryl 3-ethoxysulphosuc-cinate by means of a 4-day repeated open exposure model in order to achieve a more realistic mimicry of daily practice.〈section xml:id="abs1-2"〉〈title type="main"〉Methods: The effects of the exposures were evaluated by: a) number of fulfilled exposures, b) visual score after exposures, and c) transepidermal water loss (TEWL) after exposures.〈section xml:id="abs1-3"〉〈title type="main"〉Results: In the majority of subjects, exposure to LAU had to be stopped because of burning sensations, erythema and/or scaling. The number of fulfilled exposures to LAU was lower than that of SLS. The other agents were tolerated very well. These less irritative agents had much lower visual scores and TEWL values after the repeated exposures compared with LAU and SLS.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusions: The explanation for the irritant nature of LAU in the present study might be the type of alkyl chain length distribution. Its 12-carbon chain content was ≤ 99%, and this agent can therefore be designated as pure sodium laurate. The same holds true for SLS. In daily practice, however, soap is a mixture of different – less irritant – chain lengths. Therefore, these findings cannot be extrapolated to commercially available soap bars.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1600-0846.1997.tb00175.x

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Evaluation of analytical methods. Analysis of minocycline by liquid chromatography (1992)

Naidong, Weng ; Vermeulen, K. ; Quintens, I. ; [et al.]

Springer

Chromatographia 33 (1992), S. 560-566

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ISSN: 1612-1112

Keywords: Column liquid chromatography ; Official methods of analysis ; Method evaluation ; Minocycline

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Summary The liquid chromatographic methods laid out for the analysis of minocycline hydrochloride in the British Pharmacopoeia 1988, the United States Pharmacopeia XXII and the Pharmacopée Française 10 were examined. The major difference between these methods lies in the adjustment of the pH of the mobile phase. The analyst has to obtain the right pH of the mobile phase for his available column. This was found to be a less than easy task for the occasional analyst. Other disadvantages observed were poor solubility of the components of the mobile phase, reduced sensitivity due to UV absorbance by the mobile phase, rather high back pressure, the elution order for 9-minocycline depending on the brand of stationary phase, and above all, poor stability of the stationary phase.