ISSN:
1590-3478
Keywords:
Pericellular nets
;
Golgi
;
Ramón y Cajal
;
History of neuroscience
;
Extracellular matrix
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Description / Table of Contents:
Sommario Gli involucri perineuronali sono strutture a rate che avvolgono i pirenofori e i grossi dendriti di numerose popolazioni neuronali. Scoperti da Camillo Golgi, che li descrisse dettagliatamente net 1898, furono studiati intensamente dai maggiori neuroistologi dell’epoca per circa un ventennio. L’opinione di Ramón y Cajal the gli involucri perineuronali fossero artefatti delta fissazione interruppe la prima fase di ricerche. Solo pochi ricercatori, fra cui i neurologi Besta e Belloni, continuarono gli studi fino agli anni Trenta, documentando la morfologia degli involucri perineuronali nell’ encefalo di diversi mammiferi e dell’ uomo in condizioni normali e patologiche. Solo dopo un cinquantennio, i progressi in campo citochimico consentirono di chiarire non solo l’effettiva esistenza degli involucri perineuronali, ma anche la loro composizione chimica, dimostrando the essi sono complesse organizzazioni di molecole delta matrice extracellulare, principalmente glicoproteine e proteoglicani. Le ricerche sugli involucri perineuronali coinvolgono oggi numerosi gruppi di ricerca impegnati a chiarirne le proprietà biologiche e it significato funzionale.
Notes:
Abstract Perineuronal nets are reticular structures enwrapping cell bodies and the largest dendrites of several neuronal populations. Discovered by Camillo Golgi, who described them in detail in 1898, they were intensely studied by the most famous contemporary neurohistologists for about twenty years. The opinion of Ramón y Cajal that perineuronal nets were a fixation artifact ended the first period of studies. Only a few researchers, among whom the Italian neurologists Besta and Belloni, went on with their studies up to the 1930s documenting the morphology of perineuronal nets of different mammals and of man both in normal and in pathological conditions. Only after about fifty years, the advances in the field of cytochemistry allowed the elucidation of not only the actual existence of perineuronal nets, but also their chemical nature, showing conclusively that they are complex organisations of extracellular matrix molecules, namely glycoproteins and proteoglycans. The research on perineuronal nets today involves several groups engaged to elucidate their biological properties and functional role.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02427613
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