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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of fenoterol in pregnant and nonpregnant women (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 275-277 
    Details
    ISSN: 1432-1041
    Keywords: Fenoterol ; Pregnancy ; pharmacokinetics ; premature labour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of the β2-adrenergic drug fenoterol, which is used as a tocolytic agent in pregnancy, has been investigated in pregnant (n=9) and nonpregnant (n=5) women during a constant rate intravenous infusion. Clearance and mean residence time were found to be 1990 (1879/2220; Median, Q25/Q75) ml/min and 9.2 (8.0/14.0) min in the pregnant and 2126 (1915/2130) ml/min and 16.6 (16.5/32.1) min in the nonpregnant women, respectively. In addition, fenoterol clearance was estimated in 88 women from a single blood sample collected at steady state during IV therapy and the effect of gestational age on clearance was studied. Clearance displayed large inter-individual variation. There was no apparent correlation between clearance and gestational age. We conclude that there is no need to adjust the dose on pharmacokinetic grounds in the course of pregnancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315396
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  • 2
    Electronic Resource
    Electronic Resource
    The pharmacokinetics of theβ 2-adrenoceptor agonist fenoterol in healthy women (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 663-665 
    Details
    ISSN: 1432-1041
    Keywords: Fenoterol ; pharmacokinetics, non-linearity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied the pharmacokinetics of fenoterol in healthy women during and after a 3 h intravenous infusion of different doses within the therapeutic range for tocolysis (0.5 μg·min−1, 1.0 μg·min−1, and 2.0 μg·min−1). A specific and sensitive radioimmuno-assay was used for the determination of fenoterol. For compartmental analysis the plasma concentration time data were fitted with the TOPFIT program, assuming two exponentials. The total clearance of fenoterol increased with dose (1299 ml·min−1 at 0.5 μg·min−1, 1483 ml·min−1 at 1.0 μg·min−1, and 1924 ml·min−1 at 2.0 μg·min−1), as did the apparent volume of distribution (from 491 at the lowest to 851 at the highest dose). In contrast, the apparent half-lives were not dose-dependent, with t1/2·λ 1 4.8 min and t1/2·λ 2 52 min.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02284970
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Sequence divergence of mitochondrial DNA indicates cryptic biodiversity in Octopus vulgaris and supports the taxonomic distinctiveness of Octopus mimus (Cephalopoda: Octopodidae) (2000)
    Springer
    Marine biology 136 (2000), S. 29-35 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract DNA sequence diversity of octopods was investigated using the mitochondrial cytochrome oxidase III gene (mtCOIII). DNA was obtained from ethanol- or formalin-fixed tissue of 15 specimens belonging to Octopus mimus Gould, 1852, Octopus vulgaris Cuvier, 1797 and Scaeurgus unicirrhus d'Orbigny, 1840, from coastal waters of the Mediterranean (France), the southwestern Atlantic (Brazil), the Caribbean (Costa Rica) and the southeastern/tropical Pacific (north Chile/Costa Rica). A 612 bp fragment of the mtCOIII gene was sequenced and aligned to the orthologous sequences available from northeastern Pacific Octopus species. Possible phylogenetic relationships were reconstructed. The mtCOIII gene tree revealed two main clusters, one comprised O. rubescens, O. dofleini and O. californicus, while the other included all O. vulgaris specimens, O. bimaculatus, O. bimaculoides and O. mimus. With one exception all South American haplotypes including O. bimaculatus and O. bimaculoides appeared as the sister group of the Mediterranean haplotype of O. vulgaris, indicating that most of the South American O. vulgaris specimens investigated would not belong to the recently redescribed species O. vulgaris restricted to the Mediterranean and eastern Atlantic. The treatment of O. mimus as a species distinct from Mediterranean O. vulgaris is supported by a high nucleotide divergence of 12.7%. Based on the mtCOIII gene tree the existence of cryptic species among O. vulgaris-like octopods is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002270050004
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  • 4
    Electronic Resource
    Electronic Resource
    Outcome analysis of total knee-replacements in patients with rheumatoid arthritis versus osteoarthritis (1995)
    Springer
    Archives of orthopaedic and trauma surgery 114 (1995), S. 330-334 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A total of 524 knees underwent a primary PCA knee arthroplasty between 1982 and 1989. Of these 415 suffered from osteoarthritis (OA) and 61 from rheumatoid arthritis (RA). They were analyzed for differences regarding the outcome. Neither survivorhsip analysis nor number or type of revisons revealed statistical differences among these two groups. The knee score rose in the OA group from a median of 28 to 89 points after 1 year and then dropped to 87 points between 54 and 118 months. In the RA group the median of the knee score rose from a preoperative value of 21 points to 90 points after 1 year but then dropped to 77 points at the most recent followup. This development was probably the result of general progression of the disease. Even in the RA group the rating was still “good” at the latest follow-up. Regarding the benefit of such a procedure in a polyarticular disease and its preservation over a long period of time, total knee arthroplasty can be recommended for patients with RA, and preferably the cemented version.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00448956
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    Paper (German National Licenses)
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