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  • 1
    Electronic Resource
    Electronic Resource
    Effects of epinephrine on glucose metabolism in patients with alcoholic liver cirrhosis (1996)
    Springer
    Intensive care medicine 22 (1996), S. S78 
    Details
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion In contrast to its preserved stimulatory effect on lipolysis epinephrine failed to enhance hepatic glucose production in cirrhotic patients. Since this blunted response was not related to changes of ß-adrenoreceptors our findings suggest that epinephrine resistance in cirrhosis was due to a postreceptor defect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01921252
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Wert der Spiral-CT im Staging von Karzinomen der Mundhöhle und des Oro- und Hypopharynx (2000)
    Springer
    Der Radiologe 40 (2000), S. 632-639 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Spiral-CT ; Mundhöhle/Oropharynx/Hypopharynx ; Karzinome ; Staging ; Key words Spiral CT ; Oral cavity/oropharynx/hypopharynx ; Carcinoma ; Staging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Purpose. To compare spiral and conventional CT in the staging of carcinomas of the oral cavity, the oropharynx and hypopharynx. Method. Retrospectively 101 conventional CTs and prospectively 107 spiral CTs were analyzed regarding to correct T and N staging. CT results were compared with histological staging. Results. In conventional CT, there were correctly staged 85% of T stages (T1 62%, T2 74%, T3 81%, T4 94%) and 85% of N stages (N0 79%, N1 71%, N2 89%, N3 94%). Spiral CT showed correct results in 84% of T stages (T1 67%, T2 74%, T3 88%, T4 95%) and in 86% of N stages (N0 82%, N1 78%, N2 90%, N3 93%). No statistically significant differences could be found between both CT methods. Conclusion. In spite of the tendency of improved diagnosis of T1, N0 and N1 stages no clear improvement in the staging of carcinomas of the oral cavity, the oropharynx and hypopharynx could be expected by spiral CT.
    Notes: Zusammenfassung Fragestellung. Ziel der Studie war ein Vergleich konventioneller CT und Spiral-CT im Staging von Karzinomen der Mundhöhle, des Oro- und Hypopharynx. Methode. Retrospektiv wurden 101 konventionelle CTs und prospektiv 107 Spiral-CTs auf Korrektheit des T- und N-Stagings überprüft. Als Golden Standard galt das histologische Staging. Ergebnisse. Mit der konventionellen CT wurden jeweils 85% der Tumore korrekt einem T-Stadium (T1 62%, T2 74%, T3 81%, T4 94%) und einem N-Stadium (N0 79%, N1 71%, N2 89%, N3 94%) zugeordnet. Die Spiral-CT stufte 84% der Fälle richtig im T-Stadium (T1 67%, T2 74%, T3 88%, T4 95%) und 86% im N-Stadium (N0 82%, N1 78%, N2 90%, N3 93%) ein. Die Unterschiede im T- und N-Staging zwischen beiden CT-Methoden waren statistisch nicht signifikant. Schlussfolgerung. Trotz der Tendenz der besseren Beurteilbarkeit von T1-, N0- und N1-Stadien ist von der Spiral-CT keine eindeutige Verbesserung im Staging von Karzinomen der Mundhöhle, des Oro- und Hypopharynx zu erwarten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050785
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of atropine on feedback regulation of pancreatic secretion in rats (1989)
    Springer
    Research in experimental medicine 189 (1989), S. 221-228 
    Details
    ISSN: 1433-8580
    Keywords: Feedback regulation ; Pancreatic enzymes ; Camostate ; Atropine ; Cholecystokinin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the present study the effect of atropine on feedback regulation of pancreatic function was investigated in male rats. Orogastric tube feeding of a single dose of the protease inhibitor camostate (100 mg) caused a 6-fold increase in plasma CCK. This was accompanied by a 50% decrease in pancreatic enzyme content for up to 6h. The effect of i.v. infusion of atropine (100 µg · kg−1 · h−1) was studied 60 and 180 min after camostate feeding. Atropine completely abolished the decrease in enzyme content 180 min after camostate feeding. The stimulated CCK plasma levels were significantly lowered by the infusion of atropine 60 min, but not 180 min, after feeding of camostate. It is discussed that a cholinergic pathway mediates CCK release in the early phase of feedback regulation of pancreatic function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852170
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  • 4
    Electronic Resource
    Electronic Resource
    Stimulation of pancreatic secretory process in the rat by low-molecular weight proteinase inhibitor (1987)
    Springer
    Cell & tissue research 249 (1987), S. 63-67 
    Details
    ISSN: 1432-0878
    Keywords: Exocrine pancreas ; Proteinase inhibitor ; Cholecystokinin ; Protein synthesis ; Enzyme synthesis ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Oral application of a single dose of a new synthetic proteinase inhibitor Camostate (Foy-305) in male Wistar rats was carried out together with studies of in vitro amino acid incorporation followed by separation of proteins by two-dimensional gel electrophoresis. The aim of this experiment was to analyze changes produced by the inhibitor in total protein and individual enzyme biosynthesis. Administration of 100 mg/kg Foy-305 resulted in significant inhibition of total pancreatic protein synthesis, without changes in fractional rates for individual enzymes. 50 mg/kg Foy-305 induced a 10-fold elevation of cholecystokinin (CCK) levels in serum; this persisted for 3 h and led to a significant increase in the total rate of protein synthesis with peak values at 6 and 9 h (78% and 84% above control levels, respectively), returning to control by 15h. Changes in fractional rates of synthesis occurred with a latency of 6 h and were restricted to amylase and the anionic form of trypsinogen and chymotrypsinogen. Amylase biosynthesis decreased by about 40% from control levels at 9 h to return to control levels by 15 h. Increased synthesis of trypsinogen and chymotrypsinogen was observed; this was also phasic. The results show similar enzyme-specific regulation as previously described for exogenous CCK stimulation and for the adaptation of the pancreas to diets enriched in protein. They demonstrate the effectiveness of pulsatory endogenous hormone release in the regulation of protein synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00215419
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  • 5
    Electronic Resource
    Electronic Resource
    Das undifferenzierte Karzinom mit lymphozytärem Stroma im Kopf-Hals-Bereich (1999)
    Springer
    Der Onkologe 5 (1999), S. 968-974 
    Details
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Das undifferenzierte Karzinom mit lymphozytärem Stroma des Nasopharynx, auch Schmincke-Tumor oder lymphoepithelieales Karzinom genannt, macht ca. 30% aller Nasopharynxkarzinome aus. Es ist in Europa mit einer Inzidenz zwischen 0,1 bis 0,3/100.000 Einwohnern sehr selten und kommt häufiger in südasiatischen Ländern vor. Bei der Tumorentstehung spielt das Epstein-Barr-Virus eine Rolle. Die Lokalisation außerhalb des Nasopharynx stellt eine Rarität dar, es liegen lediglich einige Fallberichte vor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007610050457
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  • 6
    Electronic Resource
    Electronic Resource
    Stimulation of pancreatic secretory process in the rat by low-molecular weight proteinase inhibitor (1987)
    Springer
    Cell & tissue research 247 (1987), S. 187-193 
    Details
    ISSN: 1432-0878
    Keywords: Exocrine pancreas ; Proteinase inhibitor ; Feedback regulation ; Cholecystokinin ; Fine structure ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Application of a single dose of a new type of proteinase inhibitor camostate (FOY-305) via orogastric tube was used in rats to study the dose-response relationship of resulting pancreatic stimulation. Doses up to 10 mg/ kg failed to elicit any response, while significant decrease in enzyme content and increase in serum CCK-levels were observed with doses ranging from 25 to 400 mg/kg. A single dose of 100 mg/kg was selected for a time-sequence analysis, which revealed a 60 to 70% depletion of enzyme stores persisting over 6 h and reverting to control levels by 12 h. Peak increases in serum CCK-levels (15-fold above the elevation observed after regular food intake) were found after 30 min and persisted as an 8-to 10-fold elevation for at least 3 h, then declined to control levels by 9 h. This prolonged endogenous hormone release and resulting pancreatic stimulation were also verified in a separate group of animals in which volume, protein, and enzyme output were measured after cannulation of the pancreatic duct. While volume secretion was not altered by feeding a single dose of 100 mg/kg FOY-305, protein and enzyme output increased 2-to 3-fold over a period of 7 h. Fine-structural analysis of the pancreas demonstrated efficient depletion of zymogen granules from acinar cells with all doses between 50 and 400 mg/kg, accompanied by the appearance of membrane material in the acinar lumina at 3 and 6 h. The same transient increase in the number of lysosomal bodies predominantly containing mitochondria with all doses above 50 mg/kg was interpreted as increased organelle turnover due to persisting hormonal stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00216561
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