ISSN:
1619-7089
Keywords:
Key words: Tumor vaccine-draining lymph nodes
;
Immune deviation
;
Sentinel lymph nodes
;
Immunological monitoring
;
Tumor vaccines
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract. Recently, it was recognized that an immune response develops along one of two major pathways. One leads to a destructive immune response (type 1), while the alternative leads to a nondestructive immune response (type 2). Our studies in animal models suggest that therapeutic vaccines induce a tumor-specific type 1 immune response while ineffective vaccines induce a type 2 response. These results have led us to examine the immune response in sentinel lymph nodes draining tumor vaccines of patients entered onto clinical trials for melanoma, breast and renal cell cancer.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002590050578
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