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  • 1
    Electronic Resource
    Electronic Resource
    Decreased mineralization in hemodialysis patients after subtotal parathyroidectomy (1982)
    Springer
    Calcified tissue international 34 (1982), S. 16-20 
    Details
    ISSN: 1432-0827
    Keywords: Histomorphometry ; Renal osteodystrophy ; Mineralization ; Subtotal parathyroidectomy ; Densitometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Many hemodialysis patients undergo subtotal parathyroidectomy (sPTx) because of the complications of severe secondary hyperparathyroidism. In some patients, however, renal osteodystrophy fails to regress. In uremia, the high levels of circulating immunoreactive parathyroid hormone (iPTH) which accompany osteitis fibrosa are associated with accelerated bone formation. After sPTx, the fall in iPTH may decrease mineralization and increase osteoid formation. Bone histomorphometry, densitometry, and serum biochemical determinations were done in 20 patients on regular maintenance hemodialysis and after sPTx in 3 additional patients. Densitometry at the radial diaphysis was inversely related to osteoid volume so that low bone mineral content indicated excess osteoid. Elevated serum alkaline phosphatase activity was associated with osteitis fibrosa. Tetracycline double labels identified 5 patients with an increased rate of mineralization. Levels of iPTH and serum phosphorus were positively correlated to the mineralization rate. The fall in iPTH after sPTx was accompanied by a reduction in osteitis fibrosa and decreased mineralization. The nonosteoblastic osteoid became more abundant. After sPTx some hemodialysis patients may convert the osteitis fibrosa to a poorly treatable low turnover osteomalacia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02411202
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  • 2
    Electronic Resource
    Electronic Resource
    Pseudofractures in the absence of osteomalacia (1982)
    Springer
    Skeletal radiology 8 (1982), S. 17-19 
    Details
    ISSN: 1432-2161
    Keywords: Pseudofractures ; Osteomalacia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The presence of bilateral pseudofractures is generally considered a reliable radiologic diagnostic feature of osteomalacia. We report two women with long-standing bilaterally symmetrical femoral pseudofractures that did not demonstrate the histologic features of osteomalacia upon examination of non-decalcified sections of iliac crest bone. One patient treated empirically for osteomalacia developed evidence of early vitamin D intoxication. We conclude that there is no completely reliable non-invasive diagnostic test for osteomalacia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00361362
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Focal mineralization defect during disodium etidronate treatment of calcinosis (1982)
    Springer
    Calcified tissue international 34 (1982), S. 224-228 
    Details
    ISSN: 1432-0827
    Keywords: Diphosphonates ; Histomorphometry ; Mineralization ; Calcinosis ; Osteomalacia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The use of disodium etidronate (EHDP) for the treatment of calcinosis is complicated by the threat of drug-induced inhibition of skeletal mineralization. Adults with Paget's disease of bone treated for 6 months with 10–20 mg/kg/day of EHDP have been reported to show both a marked delay in mineralization and a diffuse excess of unmineralized bone matrix. Drug-induced bone disease is, however, a function of growth as well as of the dose and duration of therapy. Therefore, children treated with EHDP may respond differently to the drug-induced mineralization defect. A 10-year-old girl with dermatomyositis developed incapacitating ectopic calcification. After 9 months of therapy with 12 mg/kg/Day of EHDP, a small decrease in the calcinosis was accompanied by a dramatic increase in joint mobility. Bone mineral content of the radial diaphysis showed a failure to gain mineral density as expected with prepubertal growth (8 cm/year). Bone biopsy revealed a patchy excess of osteoid. Although the percentage of osteoid surface labeled by tetracycline was reduced, normal mineralization was evident in the double-labeled areas. In children, the mineralization defect occurring with EHDP treatment may be focal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02411241
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    Paper (German National Licenses)
    Fulltext
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