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  • 1
    Electronic Resource
    Electronic Resource
    Fluid loading of a Lamb-wave sensor (1988)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 52 (1988), S. 1653-1655 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We describe the fluid loading of Lamb waves propagating in a 3 mm×9 mm composite membrane consisting of low-stress silicon nitride deposited by low-pressure chemical vapor deposition (2.0 μm thick) supporting an aluminum ground plane (0.3 μm), a piezoelectric zinc oxide layer (0.7 μm), and a pair of 100-μm-period interdigital Al transducers (0.5 μm). When this device is operated in air, the phase velocity of the lowest antisymmetric mode is 474 m/s; it changes to 304 and 322 m/s, respectively, when the membrane is loaded on one side with de-ionized water and with methanol. The large fluid-loading effect, in excellent agreement with theory, and the stability of an oscillator made with this membrane (stability better than 1 part in 106) suggest the utility of the device as a sensitive densitometer and pressure sensor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.99047
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  • 2
    Electronic Resource
    Electronic Resource
    Analytic comparison of the sensitivities of bulk-wave, surface-wave, and flexural plate-wave ultrasonic gravimetric sensors (1989)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 54 (1989), S. 1976-1978 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We show that, for small added masses, the sensitivities of bulk-mode, surface-mode, and flexural plate-mode gravimetric ultrasonic sensors are respectively 2/ρλ, ≈1/ρλ, and 1/2ρd, where ρ is the density of the sensor substrate material, λ is the wavelength, and d is the plate thickness of the flexural-mode sensor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.101189
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of treatment with omalizumab, an anti-IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma (2005)
    Oxford, UK : Munksgaard International Publishers
    Allergy 60 (2005), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Patients with severe persistent asthma who are inadequately controlled despite treatment according to current asthma management guidelines have a significant unmet medical need. Such patients are at high risk of serious exacerbations and asthma-related mortality.Methods:  Here, we pooled data from seven studies to determine the effect of omalizumab, an anti-immunoglobulin E (IgE) monoclonal antibody, on asthma exacerbations in patients with severe persistent asthma. Omalizumab was added to current asthma therapy and compared with placebo (in five double-blind studies) or with current asthma therapy alone (in two open-label studies). The studies included 4308 patients (2511 treated with omalizumab), 93% of whom had severe persistent asthma according to the Global Initiative for Asthma (GINA) 2002 classification. Using the Poisson regression model, results were calculated as the ratio of treatment effect (omalizumab : control) on the standardized exacerbation rate per year.Results:  Omalizumab significantly reduced the rate of asthma exacerbations by 38% (P 〈 0.0001 vs control) and the rate of total emergency visits by 47% (P 〈 0.0001 vs control). Analysis of demographic subgroups showed that the efficacy of omalizumab on asthma exacerbations was unaffected by patient age, gender, baseline serum IgE (split by median) or by 2- or 4-weekly dosing schedule, although benefit in absolute terms appeared to be greatest in patients with more severe asthma, defined by a lower value of percentage predicted forced expiratory volume in 1 s (FEV1) at baseline.Conclusions:  These results suggest that omalizumab may fulfil an important need in patients with severe persistent asthma, many of whom are not adequately controlled on current therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.2004.00770.x
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  • 4
    Electronic Resource
    Electronic Resource
    Mechanisms of severe asthma (2003)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 33 (2003), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The mechanisms behind the development of severe asthma are poorly understood. However, these patients disproportionately consume healthcare resources related to asthma. Severe asthma may develop over time, or may develop shortly after onset of the disease. The genetic and environmental elements that may be most important in the development of severe disease are poorly understood. Physiologically, these patients often have air trapping and airway collapsibility. The pathology demonstrates a heterogeneity of findings, including continued eosinophilic inflammation, an apparently different pathology, structural changes likely to be remodelling related, and predominant distal disease. Treatment remains problematic and likely will remain so until a better understanding of this disease develops.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2003.01799.x
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  • 5
    Electronic Resource
    Electronic Resource
    Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition (2002)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 32 (2002), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Although 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), a product of 15-lipoxygenase (15-LO), may be involved in mild to moderate asthma, little is known about its potential roles in severe asthma.Objectives This study was performed to evaluate 15(S)-HETE levels in bronchoalveolar lavage fluid (BALF) from severe asthmatics with and without airway eosinophils and from the control groups. In addition, 15-LO protein expression was examined in endobronchial biopsy, while its expression and activation were evaluated in BAL cells.Results While 15(S)-HETE levels in BALF were significantly higher in all severe asthmatics than normal subjects, severe asthmatics with airway eosinophils had the highest levels compared with mild, moderate asthmatics and normal subjects. 15(S)-HETE levels were associated with tissue eosinophil numbers, sub-basement membrane thickness and BALF tissue inhibitor of metalloproteinase-1 levels, and were accompanied by increased 15-LO expression in bronchial epithelium. In addition, activation of 15-LO was suggested by the increased proportion of 15-LO in the cytoplasmic membrane of alveolar macrophages from severe asthmatics.Conclusion The data suggest that severe asthmatics with persistent airway eosinophils manifest high levels of 15(S)-HETE in BALF, which may be associated with airway fibrosis. It is likely that 15-LO expression and activation by airway cells explain the increased 15(S)-HETE levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2002.01477.x
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  • 6
    Electronic Resource
    Electronic Resource
    Ultrastructural findings on the skeletal muscles of pigs following ultrarapid chilling in the initial phase of meat maturation
    Amsterdam : Elsevier
    Meat Science 31 (1992), S. 367-380 
    Details
    ISSN: 0309-1740
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0309-1740(92)90021-U
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  • 7
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1994)
    Springer
    Naturwissenschaften 81 (1994), S. 231-233 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01138551
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  • 8
    Electronic Resource
    Electronic Resource
    Tumoroxygenierung unter kombinierter Ganzkörperhyperthermie und Polychemotherapie Untersuchungen am Beispiel eines Rezidivkarzinoms der Mundhöhle (2000)
    Springer
    HNO 48 (2000), S. 949-954 
    Details
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Tumoroxygenierung ; Hyperthermie ; Polychemotherapie ; Rezidiv- und Mundhöhlenkarzinom ; Keywords Tumor oxygenation ; Hyperthermia ; PolychemotherapyRecurrent squamous epithelium carcinoma of the oral cavity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background and objective. Previous studies have reported synergistic effects of combined hyperthermia and chemotherapy and/or irradiation. The response to irradiation and chemotherapy of well-oxygenated and vascularized tumors generally is better than that of hypoxic tumors. Therefore, tumor oxygenation is recognized as an important predictive factor in the therapy of malignant tumors. In practice, the head and neck area remains outside of the hyperthermia chamber during whole-body hyperthermia. It was the aim of this study to evaluate if the head and neck region receives sufficient warmth and, if so, if tumor oxygenation increases accordingly. Patients/methods. Whole-body hyperthermia, as heat radiation (Enthermics Medical Systems RHS-7500), was applied to the narcotised 60-year-old male patient with a local recurrence tumor pT3 pN2b M0 squamous cell carcinoma of the oral cavity. Tumor oxygenation and temperature were measured by LICOX catheters via one-point measurement during the entire hyperthermia treatment (3.5 h). Parallelly, chemotherapy (ifosfamide/Carboplatin) was given in four cycles (one cycle/month). Results. With a latency of 10 min the increase of intratumoral temperature was comparable to temperatures achieved in the esophagus. The maximum intratumoral temperature was 41.8°C. The average increase in tumor oxygenation was more than 100%. The clinical outcome in the case presented was a partial tumor remission (PR). Conclusions. During combined whole-body hyperthermia and polychemotherapy, tumor oxygenation is also significantly improved in the head and neck area, despite the fact that the head and neck area remained outside the hyperthermia chamber. The intratumoral temperature was comparable to esophageal and rectal temperatures.
    Notes: Zusammenfassung Hintergrund und Fragestellung. Die Wirksamkeit der Hyperthermie in der Kombinationsbehandlung mit ionisierender Strahlung und/oder Chemotherapie ist in zahlreichen Studien postuliert worden. Der Wirkungsmechanismus ist derzeit nicht vollständig geklärt. Eine Hyperthermie führt zu einer Erhöhung der Durchblutung und sollte dadurch eine Erhöhung der Tumoroxygenierung bewirken, die ein wichtiger prognostischer Faktor in der Behandlung maligner Tumoren ist. Diese Untersuchung sollte klären, ob unter den Bedingungen der Ganzkörperhyperthermie des Rumpfes außerhalb der Wärmekammer gelegene Regionen wie das Kopf-Hals-Gebiet adäquat erwärmt werden und welchen Einfluss dies auf die Tumoroxygenierung hat. Patient/Methodik. Die Ganzkörperhyperthermie wurde als strahlende Wärme (Enthermics Medical Systems RHS-7500) einem 60jährigen Patienten mit Rezidiv eines pT3pN2bM0-Mundhöhlenkarzinoms der Zunge unter intensivmedizinischen Bedingungen in Intubationsnarkose appliziert. Die Tumoroxygenierung und -temperatur wurde mit Licox®-Messsonden an jeweils einem Messpunkt im Zentrum des Tumors über die gesamte Behandlungsdauer (3,5 h) aufgezeichnet. Parallel dazu wurde die Chemotherapie (Ifosfamid/ Carboplatin) über 4 Therapiezyklen appliziert. Ergebnisse. Der Temperaturverlauf im Tumor entspricht mit einer Latenz von 10 min den ösophageal gemessenen Werten. Das Temperaturmaximum beträgt sowohl im Ösophagus als auch im Tumor 41,8°C. Parallel zur Temperaturerhöhung im Tumor stieg der Tumor pO2 um durchschnittlich 100% während der Behandlung. Klinisch ließ sich eine partielle Remission erreichen. Schlussfolgerungen. Eine kombinierte Ganzkörperhyperthermie und Polychemotherapie verbessert bei Kopf-Hals-Tumoren die Tumoroxygenierung. Die erreichbaren Temperaturen entsprechen den ösohagealen oder rektalen Messwerten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050693
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of lesions of the locus coeruleus complex on the circadian rhythm of plasma corticosterone in the mouse (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 1126-1127 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary An apparently transient elevation of basal morning (08.00 h) plasma corticosterone levels in male mice was found 48 h after bilateral electrolytic lesions of the brainstem locus coeruleus complex but was not observed 6 weeks after lesioning.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01949984
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  • 10
    Electronic Resource
    Electronic Resource
    Versorgung einer thorakalen Aortenruptur ohne Einsatz einer Herz-Lungen-Maschine (2000)
    Springer
    Intensivmedizin und Notfallmedizin 37 (2000), S. 48-52 
    Details
    ISSN: 1435-1420
    Keywords: Key words Blunt chest trauma – rupture of the thoracic aorta – risks of aortic cross-clamping ; Schlüsselwörter Stumpfes Thoraxtrauma – Ruptur der thorakalen Aorta – Risiken der Clampingtechnik
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Am Beispiel eines 37jährigen Patienten, der im Rahmen eines Verkehrsunfalls ein stumpfes Thoraxtrauma mit Rippenserienfrakturen beidseits, eine Lungenkontusion mit Hämatothorax sowie akute Blutungen in Mediastinum und Pleura aufgrund einer Ruptur der thorakalen Aorta erlitt, soll erörtert werden, inwieweit ein solches Verletzungsmuster bei dringlicher chirurgischer OP-Indikation auch an Kliniken ohne Verfügbarkeit einer extrakorporalen Zirkulation behandelt werden kann, und welche Risiken sich daraus ergeben. Das Abklemmen (Clamping) der thorakalen Aorta, ohne die Möglichkeit einer aktiven oder passiven distalen Perfusion, birgt Risiken sowohl in Bezug auf die Entwicklung einer Paraplegie als auch in Bezug auf eine akute kardiale Dekompensation, weshalb diese Technik nur zur Anwendung kommen sollte, wenn eine Verlegung in ein Zentrum mit extrakorporaler Zirkulation aufgrund lebensbedrohlicher Begleitumstände nicht mehr möglich erscheint. Im vorliegendem Fall kam es trotz langer Abklemmzeit zu keinerlei neurologischen Defiziten.
    Notes: Summary We take this case-report of a 37 year old patient who had a rupture of the thoracic aorta as a result of traffic accident, to discuss how this injury can be managed in a hospital with no possibility of extra-corporeal circulation, and which specific risks can appear by using the simple clamping technique for aortic repair surgery. As the result of the accident we found a blunt chest trauma with multiple rib fractures on both sides, a contusion of the lungs, a hemato-thorax and acute bleeding into the mediastinum and the pleura. The clamping of the thoracic part of the aorta has high risks concerning paraplegia and acute cardiac decompensation. Therefore, this technique should only be used when transport to a clinic with extra-corporeal circulation is not practicable because of additional severe circumstances. Although we had a long period of aortic cross-clamping, no neurological deficit occurs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003900050007
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