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  • 1
    Electronic Resource
    Electronic Resource
    Effects of attentional and stressor manipulations on the P50 gating response (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Psychophysiology 34 (1997), S. 0 
    Details
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: The decline in amplitude of the P50 component of the event-related potential to the second of paired clicks has been suggested as a measure of preattentional gating. Two experiments were conducted to assess the effects of attention and .a psychological stressor on P50. Experiment 1 included two choice reaction time tasks designed to direct attention selectively to the first or second click in each pair. Results suggest that the NIOO component was responsive to attentional manipulations, whereas P50 was not affected. Experiment 2 examined the impact of a brief psychological stressor on the P50 response Parallel mental arithmetic tasks were administered silently and orally. Self-report and measures of autonomic activity were used to assess the level of stress occurring during the performance of the mental arithmetic tasks Results indicate that P50 suppression was sensitive to the acute stressor, the oral mental arithmetic task Implications of these findings for studies ofP50 suppression in schizophrenia are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-8986.1997.tb02145.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Experimental modification of P50 suppression (2001)
    Oxford, UK : Blackwell Publishing
    Psychophysiology 38 (2001), S. 0 
    Details
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: White and Yee (1997) found that normal suppression of the P50 component of the event-related potential was disrupted during a paired-click paradigm when nonpsychiatric subjects performed mental arithmetic (MA) problems aloud, concurrently with the presentation of auditory stimuli. In fact, the degree of disruption reflected in the P50 suppression ratio fell within the range that is typically observed in schizophrenia patients. The present study was conducted to clarify the processes that might underlie the apparent disruption of P50 suppression during performance of an oral MA task. Participants completed a series of tasks designed to examine the impact of competing cognitive activity, competing auditory stimulation, muscle activity, and acute psychological stress on P50 amplitude and P50 suppression. Results suggested that psychological stress and heightened facial muscle activity may exert modulatory effects on P50 suppression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1017/S0048577201981454
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Gender and suppression of mid-latency ERP components during stress (2005)
    Malden, USA : Blackwell Publishing Inc
    Psychophysiology 42 (2005), S. 0 
    Details
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Substantial research evidence suggests that women may be more reactive to stress than men. This study examined the influence of gender and stress on suppression of the P50 and N100 components of the auditory event-related potential. During a stressor task, women (n=13) showed disrupted P50 and N100 suppression whereas men (n=15) exhibited only alterations in N100 suppression. Additionally, reduced skin conductance level during stress correlated with impaired P50 suppression and elevated Click 2 amplitude of the P50 response in women. These data suggest that gender differences in response to perceived stress may be an important factor to consider in studies relying upon the P50 suppression paradigm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-8986.2005.00365.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells (2006)
    [s.l.] : Nature Publishing Group
    Nature 441 (2006), S. 984-987 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sensory hair cells of the mammalian organ of Corti in the inner ear do not regenerate when lost as a consequence of injury, disease, or age-related deafness. This contrasts with other vertebrates such as birds, where the death of hair cells causes surrounding supporting cells to re-enter the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature04849
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    Paper (German National Licenses)
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