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  • 1
    Electronic Resource
    Electronic Resource
    Haemodynamic, metabolic, and lymphocyte beta2-adrenoceptor changes following chronic beta-adrenoceptor antagonism (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 237-243 
    Details
    ISSN: 1432-1041
    Keywords: beta-antagonists ; beta2-adrenoceptor ; selectivity ; intrinsic sympathomimetic activity ; adrenaline hypokalaemia ; vasidilatation ; receptor up-regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have examined the effects of 7 days treatment with beta adrenoceptor antagonists in 8 healthy volunteers in a placebo controlled, crossover study. We investigated three beta-adrenoceptor antagonists (atenolol, oxprenolol, and propranolol), which have differing profiles of selectivity and partial agonist properties (intrinsic sympathomimetic activity, ISA). We studied adrenaline-induced hypokalaemia, the vasodilator response to an infusion of adrenaline (0.06 µg·kg−1·min−1 for 90 min), and lymphocyte beta2-adrenoceptor number, determined by (-) [125I]-iodocyanopindolol binding, and measured these variables both before and after 7 days of treatment. The beta2-mediated depressor response to adrenaline infusion was abolished by propranolol and oxprenolol but persisted after atenolol. In contrast, the hypokalaemia induced by adrenaline was abolished by all three beta-blockers. Lymphocyte beta2-adrenoceptor number increased significantly following propranolol treatment, but not after oxprenolol for atenolol. We conclude that up-regulation of lymphocyte beta2-adrenoceptors is dependent on beta2-receptor blockade and is modified by ISA. The reversal of the hypokalaemic response by atenolol suggests that beta1 receptors may contribute to the former effect. Alternatively, since different populations of beta2-adrenoceptors differ in their susceptibility to antagonists there may also be differences in agonist coupling to beta2-responses between tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607569
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of diuretic therapy on adrenaline-induced hypokalaemia and hypomagnesaemia (1988)
    Springer
    European journal of clinical pharmacology 34 (1988), S. 333-337 
    Details
    ISSN: 1432-1041
    Keywords: diuretics ; hypokalaemia ; hypomagnesaemia ; arrhythmias ; bendrofluazide ; frusemide ; spirolactone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have examined the interaction between the administration of bendrofluazide, frusemide, spironolactone, and placebo and increased plasma adrenaline concentrations in a double-blind, placebo-controlled, cross over study. We studied healthy subjects on the fourteenth day of each treatment period and after a two hour infusion of adrenaline (0.06 µg·kg−1·min−1 {0.33 nmol·kg−1·min−1}) we measured their heart rates, blood pressures, and plasma potassium and magnesium concentrations. There were no differences in heart rates or blood pressures for all four treatments. Baseline potassium concentrations were not significantly different compared to placebo, and plasma potassium fell during the period of the infusion on all study days. this fall was significantly greater on frusemide (0.5 mmol·l−1) and bendrofluazide (0.4 mmol·l−1) compared with both placebo and spironolactone. Baseline plasma magnesium concentration were not different and similar falls in plasma magnesium were seen on all four treatments during and after the adrenaline infusion. We conclude that chronic diuretic therapy with a thiazide diuretic or frusemide may increase the severity of hypokalaemia during short-term rises in plasma adrenaline. Pretreatment with spironolactone had no effect on adrenaline-induced hypokalaemia. None of the diuretics studied altered adrenaline-induced hypomagnesaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542432
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  • 3
    Electronic Resource
    Electronic Resource
    An observational study of entraining convection using balloon-borne turbulence probes and high-power Doppler radar (1979)
    Springer
    Boundary layer meteorology 16 (1979), S. 261-278 
    Details
    ISSN: 1573-1472
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Features associated with the upper limit of convection, observed by turbulence probes supported by a tethered kite balloon and by high-power Doppler radar, are described. The observations illustrate the interaction of thermal plumes with the capping inversion (and stable air aloft) and confirm the existence of non-turbulent, intermittently turbulent and fully turbulent layers. Evidence is presented for entrainment processes occurring on scales ranging from a few metres to several hundred metres. Individual distortions of the inversion interface, tracked by the radar, have a lifetime of about 5 minutes. Other, larger scale (i.e., 〉 1 km) perturbations of the top of the boundary layer were observed over longer periods, and are thought to be due to topographical effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02220486
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    Paper (German National Licenses)
    Fulltext
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