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  • 1
    Electronic Resource
    Electronic Resource
    Emollients in a propanol-based hand rub can significantly decrease irritant contact dermatitis (2005)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Contact dermatitis 53 (2005), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The objective of this study is to determine the effect of emollients in a propanol-based hand rub on skin dryness and erythema. In this prospective, randomized, controlled, double-blind trial, 35 subjects participated; of them approximately half were atopic (modified Erlanger atopy score ≥8). 2 propanol-based formulations were tested in a repeated open application test, 1 contained a mixture of emollients (0.81%, w/w). 2 aliquots of 0.7 ml of each formulation were applied twice per day over 2 weeks to the cubital fossa of each subject after random assignment of the preparations. Treatment areas were assessed before each application and 3 days postfinal application by visual inspection for erythema and dryness according to a standard scale. The sum score over all assessment time-points served as primary parameter. The mean sum score for erythema and dryness was significantly lower for the hand rub with emollients (0.8 ± 2.4) in comparison with that for the hand rub without emollients (1.5 ± 3.5; P = 0.022; Wilcoxon signed rank test). A comparison of the atopic and non-atopic subjects revealed no significant difference for any of the products (P 〉 0.05; Mann–Whitney U-test). It is concluded that the addition of emollients to a propanol-based hand rub can significantly decrease irritant contact dermatitis under frequent-use conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2005.00727.x
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  • 2
    Electronic Resource
    Electronic Resource
    Scale-sensitive fractal analysis using the patchwork method for the assessment of skin roughness (2001)
    Copenhagen : Munksgaard International Publishers
    Skin research and technology 7 (2001), S. 0 
    Details
    ISSN: 1600-0846
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background/aims: As skin roughness and wrinkles are easily perceived by the consumer, quantifying skin surface structures is a vital parameter for cosmetic product development. As more tools are available for measuring three-dimensional (3-D) surface data, instead of two-dimensional (2-D) profile lines, new algorithms are desirable, to take advantage of the information gathered.Methods: The patchwork method tiles topographic data sets virtually and analyzes the change in apparent area as a function of tile scale. The patchwork method and conventional 2-D profilometric analysis were applied to 24 topographic skin data sets. The data sets were derived before and after application of 15% glycerol solution on the skin of eight volunteers.Results: One hour after application, skin roughness decreased by 20.8%, as measured by conventional analysis, and by 23.3%, as measured by the patchwork method. For both methods, the differences were not significant.Conclusions: The patchwork method can be applied to skin data and renders results similar in intensity and direction to conventional 2-D analysis. It is advantageous over conventional 2-D analysis in three ways: it makes use of the full topologic information, it requires no high-pass or low-pass filtering, and it is independent of the anisotropy of the skin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0846.2001.70304.x
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  • 3
    Electronic Resource
    Electronic Resource
    Cutaneous sodium Iauryl sulfate irritation potential: age and regional variability (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 23 (1990), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1990.tb05102.x
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  • 4
    Electronic Resource
    Electronic Resource
    The Darkest Regions of Solar Polar Coronal Holes Observed by SUMER on SOHO (1998)
    Springer
    Astrophysics and space science 264 (1998), S. 43-52 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1002411723017
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  • 5
    Electronic Resource
    Electronic Resource
    Eine neue Versuchsanordnung zur Belastbarkeitsprüfung von Achillessehnen (1973)
    Springer
    Research in experimental medicine 160 (1973), S. 80-88 
    Details
    ISSN: 1433-8580
    Keywords: Rupture of tendon ; Achilles tendon ; Sehnenriß ; Achillessehne
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde eine Apparatur entwickelt, die es ermöglicht, Achillessehnen so zu reißen, daß die Rißstelle zwischen den Einspannungsvorrichtungen für Sehnenspiegel und Calcaneus und somit im Bereich der freien Sehnenlänge liegt. Das Setzen einer Sollrißstelle ist bei dieser Versuchsanordnung nicht erforderlich. Mit dieser Apparatur wurde in zwei parallelen Versuchsreihen die maximale Rißfestigkeit bei a) dynamischen (impulsartigen) und b) statischen (langsam erfolgenden) Belastungen geprüft. Bei dynamischer Belastung ergaben sich wesentlich höhere Werte (maximal 930 kp) als bei statischer (maximal 680 kp).
    Notes: Summary An apparatus has been constructed which made it possible to tear Achilles tendons such as the rupture was located between the strain device of the tendon and calcaneus and thus in the reach of the free length of the tendon. Setting a propitious cut was not necessary with this method. With this construction the maximal solidity before rupture was examinated in two parallel experiments with a) dynamic (impulsive) and b) static (slowly imposed) charge. With dynamic charge there were obtained essentially higher data (max. 930 kp) than could be with static charge (max. 680 kp).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852582
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  • 6
    Electronic Resource
    Electronic Resource
    SLS-irritated human skin shows no correlation between degree of proliferation and TEWL increase (1998)
    Springer
    Archives of dermatological research 290 (1998), S. 615-620 
    Details
    ISSN: 1432-069X
    Keywords: Key words Skin barrier function ; Proliferation ; Sodium lauryl sulphate ; Keratinocytes ; Transepidermal ; water loss
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It is well known that cutaneous irritants influence epidermal proliferation but the pathogenesis is poorly understood. Recent investigations have shown that the skin barrier integrity influences the proliferation of the basal keratinocytes. Our question was whether the proliferating activity of keratinocytes is indeed regulated by the degree of skin barrier damage or by a direct toxic action of the irritant on the keratinocytes. Therefore various degrees of skin irritation were induced by the application of 0.1%, 0.5% and 2% sodium lauryl sulphate (SLS) solution to the forearm skin of six healthy volunteers. This experiment was performed to evaluate the relationship between SLS concentration and epidermal proliferation. In a second experiment another 14 volunteers were treated with a single SLS concentration (0.5%) to look for interindividual differences in the patterns of skin reaction and susceptibility to the irritant. Skin barrier function was evaluated by measurements of transepidermal water loss (TEWL) before and after irritation. Punch biopsies were taken after 96 h from exposed areas and from unexposed normal skin. Dividing keratinocytes were identified immunocytochemically using three different monoclonal antibodies: PCNA, MIB 1 and KiS1. Exposure to SLS resulted in concentration-dependent increases in both TEWL and epidermal proliferation. However, no significant correlation could be found between the degree of hyperproliferation and the TEWL changes. The results suggest that epidermal proliferation is modulated by a direct interaction of the surfactant with the keratinocytes and/or by release of mediators rather than the consequence of a barrier disturbance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050361
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  • 7
    Electronic Resource
    Electronic Resource
    Rotation and precession of comet Halley (1987)
    [s.l.] : Nature Publishing Group
    Nature 327 (1987), S. 27-30 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Measurements obtained during the recent appearance of comet Halley suggest that its nucleus undergoes free and forced precession motions. Periodicities of 2.2 and 7.4 days can be explained by a 2.2-day rotation about the minor axis and a free-precessional period of 14.8 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/327027a0
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  • 8
    Electronic Resource
    Electronic Resource
    Penicillamin-induzierte Elastosis perforans serpiginosa (1994)
    Springer
    Der Hautarzt 45 (1994), S. 45-47 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter: Elastosis perforans serpiginosa – M. Wilson – D-Penicillamin ; Key words: Elastosis perforans serpiginosa – Wilson disease –D-Penicillamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract. Elastosis perforans serpiginosa is a rare disease with variable etiology. We report on a 33-year-old male patient in whom the disease was induced by long-term treatment with the chelating agent D-penicillamine.
    Notes: Zusammenfassung. Die Elastosis perforans serpiginosa ist eine seltene Erkrankung mit unterschiedlicher Ätiologie. Bei dem von uns vorgestellten 35jährigen Patienten wurde das Krankheitsbild durch die langjährige Einnahme des Chelatbildners D-Penicillamin induziert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00013256
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  • 9
    Electronic Resource
    Electronic Resource
    In Vivo Skin Penetration of Acitretin in Volunteers Using Three Sampling Techniques (1993)
    Springer
    Pharmaceutical research 10 (1993), S. 1291-1294 
    Details
    ISSN: 1573-904X
    Keywords: acitretin ; human ; topical ; percutaneous penetration ; skin sampling techniques
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Etretinate and acitretin are given orally to treat psoriasis and various keratinization disorders. Acitretin, the main active metabolite of etretinate, has the pharmacokinetic advantage of being rapidly eliminated, but it shares etretinate's toxicologic profile. Thus a topical delivery of acitretin with no or reduced systemic adverse effects is desirable. To characterize the therapeutic potential of topically delivered acitretin, we quantitatively assessed its percutaneous penetration in healthy human volunteers. Additionally, three skin sampling techniques, the punch biopsy, the shave biopsy, and the suction blister technique, were validated to quantitate acitretin in the skin. The results suggest that topical delivery of acitretin renders skin concentrations which exceed those reported after oral administration of etretinate or acitretin. However, because of possible interlaminate drug contamination, drug localization within a particular skin compartment cannot be determined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018961511730
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  • 10
    Electronic Resource
    Electronic Resource
    Tierexperimentelle Untersuchungen zur Frage der intramedullären Schienung von Röhrenknochen mit Polymethylmethacrylat (1972)
    Springer
    Archives of orthopaedic and trauma surgery 73 (1972), S. 157-163 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Autoren geben ein neues Verfahren zur intramedullären Schienung von Röhrenknochen mit Polymethylmethacrylat an. Die Methode wurde an der Tibia von Kaninchen erprobt. Die röntgenologischen Ergebnisse sind günstig. Das Verfahren kann — nach weiteren tierexperimentellen Prüfungen — nach Ansicht der Autoren bei Quer- und Schrägfrakturen der Röhrenknochen des Handskeletes angewendet werden, da es die Nachteile der AO-Verfahren (überstehende Schrauben und Platten) nicht besitzt.
    Notes: Summary The authors suggest a new method of intramedullary splinting of long bone with polymethylmethacrylat. The method has been tested on the tibia of rabbits. The x-ray results proved to be favourable. One can imagine to use this method in oblique and transverse fractures of long bone of the hand-skeleton after further animal experiments, for it does not have the disadvantages of screws and plates jutting out, that has the AO-treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00415904
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