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  • 1
    ISSN: 1573-7225
    Keywords: Age ; breast neoplasms ; Italy ; marital status ; survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: A population-based series of 4,764 women from Piedmont, Italy, who were diagnosed with breast cancer during 1979–81 and for whom information on social and demographic factors was available, was followed-up for mortality until 1986 or 1987. Relative survival rates at one, three, and five years were 94.6, 81.6, and 71.1 percent, respectively, and were similar to those of other European series. Women aged 40–49 years at diagnosis experienced a better survival than women in other age groups. The mortality was highest between one and four years after diagnosis, and lowest between five and seven years. Survival rates were lowest for women above the age of 80, and single women had a worse prognosis than married women. Women with less than seven years of education had nonsignificantly lower survival rates than more educated women. No difference in survival was found according to occupation, size of town of residence, place of birth, or type of hospital.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-7225
    Keywords: Brain neoplasms ; epidemiology ; histology ; incidence ; medulloblastoma ; New Zealand ; occupation ; race ; secular trends
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: We used New Zealand data on occurrence of different types of brain cancer to investigate: (i) a possible secular increase which has been seen worldwide and has generated considerable debate; (ii) possibly higher rates among Maori; and (iii) possibly higher risks related to social class and occupation. Data from the NZ Cancer Registry on the 5,684 brain cancers diagnosed among NZ residents from 1948–88 were used to study the pattern of occurrence by gender, age, race, calendar year, social class, occupation, and histology. Agestandardized brain-cancer incidence rates per 100,000 more than doubled over the 41-year period (from 2.9 to 6.9 in males and from 2.1 to 5.1 in females). A strong trend of increasing incidence with increasing social class is seen in males (P trend=0.01). Among Maori, the proportion of all brain cancer that is medulloblastoma is four times that among non-Maori, and the proportion of all brain cancers that lack histologic confirmation is about 40 percent higher. Elevated risks are seen among: dairy farmers (odds ratio [OR]=3.4, 95 percent confidence interval [CI]=1.9–6.0); sheep handlers (OR=2.7, CI=1.4–5.3); livestock workers (OR=3.8, CI=1.7–8.4); and farm managers (OR=3.2, CI=1.4–7.2); as well as among electrical engineers (OR=8.2, CI=20–34.7); electricians (OR=4.6, CI=1.7–12.2); and other electrical workers. Brain cancer rates in NZ have increased steadily since 1948, but this increase has leveled off in the most recent five-year period. Although brain cancer rates are likely to be underestimated among the Maori, an excess of medulloblastoma is evident in this group.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-7225
    Keywords: Breast cancer ; dioxins ; herbicides ; females ; international ; neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: The association between exposure to chlorophenoxy herbicides contaminated with dioxins and occurrence of cancer has been studied mainly in male populations. In animal experiments, gender differences have been recorded in the cancer response to administered 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Mortality and cancer incidence in an international cohort of 701 women from an International Register of Workers occupationally exposed to chlorophenoxy herbicides, chlorophenols, and dioxins is examined. Cause-specific, national death rates and cancer incidence rates were used as referents. Cancer risk was not increased overall, with a standardized incidence ratio (SIR) of 96 and 95 percent confidence interval (CI) of 64–137, based on 29 cases. Among workers exposed to those chlorophenoxy herbicides contaminated with TCDD, excess cancer incidence (for all sites) was observed (SIR=222, CI=102–422, 9 cases); this was highest in the first 10 years after exposure. No excess was observed for breast cancer, the most common cancer in this cohort. Results on cancer mortality were consistent with those on incidence.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-7225
    Keywords: Hematologic cancers ; leukemia ; men ; New Zealand ; non-Hodgkin's lymphoma ; nuclear tests
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We previously reported a study of deaths and cancer incidence in Royal NewZealand (RNZ) Navy personnel who participated in atmospheric nuclear weaponstests conducted by the United Kingdom in the Pacific in 1957-58. The studyinvolved 528 men known to have participated in the tests, and a control groupof 1,504 men who were in the RNZ Navy during the same period but were notinvolved in the tests. The original follow-up was carried out for the period1957-87 with an observed increase in risk of leukemia and other hematologiccancers, but little or no increase of non-hematologic cancers or non-cancerdeaths in test participants. Follow-up now has been extended for the period1988-92. For the total follow-up period, there were 97 deaths in testparticipants and 256 deaths in controls, a relative risk (RR) of 1.1 (90percent confidence interval [CI] = 0.9-1.3). The RR of death from causesother than cancer was 1.0 (CI = 0.8-1.3), whereas the RR of cancer death was1.2 (CI = 0.8-1 .7) and that of cancer incidence was 1.0 (CI = 0.8-1.4). Forcancers other than hematologic malignancies, the RR was 1.0 (CI = 0.7-1.5)for mortality, and 1.0 (CI = 0.7-1.3) for incidence. However, there wereeight deaths from hematologic cancers in test participants (RR = 3.8, CI =1.4-10.8), including four leukemias (RR = 5.6, CI = 1.0-41.7). The RR forincidence of hematologic cancers was 1.9 (CI = 0.8-4.3), and that forleukemia was 5.6 (CI = 1.0-41.6). We concluded that the evidence is stillconsistent with the hypothesis that some leukemias and other hematologiccancers may have resulted from participation in the nuclear weapons testprogram, but the further follow-up strengthens the evidence that there is noincreased risk for non-hematologic cancers or for causes of death other thancancer in the test participants.
    Type of Medium: Electronic Resource
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