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  • 1
    Electronic Resource
    Electronic Resource
    YM872: A Selective, Potent and Highly Water-Soluble α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptor Antagonist (2002)
    Oxford, UK : Blackwell Publishing Ltd
    CNS drug reviews 8 (2002), S. 0 
    Details
    ISSN: 1527-3458
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This review focuses on the in vitro and in vivo neuropharmacology of YM872, a potential neuroprotective agent currently undergoing clinical trials in the United States (trial name: AMPA Receptor Antagonist Treatment in Ischemic Stroke — ARTIST). Its neuroprotective properties in rats and cats with induced focal cerebral ischemia are described. YM872, [2,3-dioxo-7-(1H-imidazol-1-yl)-6-nitro-1,2,3,4-tetrahydroquinoxalin-1-yl]-acetic acid monohydrate, is a selective, potent and highly water-soluble competitive α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor antagonist. YM872 has a potent inhibitory effect on [3H]AMPA binding with a Ki value of 0.096 μM. In contrast, YM872 has very low affinity for other ionotropic glutamate receptors. The solubility of YM872 is approximately 500 to 1000 times higher than that of the other competitive AMPA antagonists: YM90K, NBQX, or CNQX. The neuroprotective efficacy of YM872 was investigated in rats and cats subjected to permanent occlusion of the left middle cerebral artery. The animals were assessed either histologically or neurologically following ischemia. In rats with occluded middle cerebral artery (MCAO) YM872, by i.v. infusion, significantly reduced infarct volume measured at 24 h and 1 week after ischemia. Significant neuroprotection was maintained even when drug administration was delayed for up to 2 h after ischemia. In addition, YM872 significantly improved neurological deficit measured at 1 week after ischemia. In cats with MCAO YM872, by i.v. infusion, dose-dependently reduced infarct volume at 6 h after ischemia. YM872 produced no behavioral abnormalities and was not nephrotoxic. The evidence for the neuroprotective efficacy of YM872 suggests its therapeutic potential in the treatment of acute stroke in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1527-3458.2002.tb00232.x
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  • 2
    Electronic Resource
    Electronic Resource
    Low Levels of mRNA for Dopamine D4 Receptor in Human Cerebral Cortex and Striatum (1996)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 66 (1996), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Significant densities of mRNA for the dopamine D4 receptor in cerebral cortex, particularly in frontal lobe, have been reported in rats and monkeys, supporting the D4 hypothesis in the pathology of schizophrenia. Using northern blot analysis and the competitive reverse transcription-polymerase chain reaction (RT-PCR) method, we determined the relative levels of D4 mRNA in human brain regions to clarify whether the cortical level is also higher in humans. Northern blot analysis revealed an unexpected profile of D4 mRNA in the brain. The detected mRNA size, 1.5 kb, was quite different from the 5.3 kb reported in human neuroblastoma SK-N-MC cells. Higher levels of D4 mRNA were detected not only in the mesolimbic system but also in the corpus callosum, spinal cord, medulla, and subthalamic nucleus. It was surprising that in the cerebral cortex regions as well as the striatum, D4 mRNA was hardly detected. The competitive RT-PCR revealed these relative densities to be at least three orders of magnitude lower than that of the striatal D2 receptor. Our results demonstrate a remarkable difference in cortical D4 mRNA density in humans compared with that in rats and monkeys. Furthermore, the mRNA distribution suggests that the higher density of D4-like binding sites reported recently in normal human striatum is not due to the D4 receptor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1996.66030915.x
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  • 3
    Electronic Resource
    Electronic Resource
    Control of calcium oscillations by phosphorylation of metabotropic glutamate receptors (1996)
    [s.l.] : Nature Publishing Group
    Nature 383 (1996), S. 89-92 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Two cell lines, HEK293 and NIH3T3 cells, were stably trans-fected with complementary DNA encoding rat mGluRla or mGluRSa, and increases in [Ca2+]j elicited by glutamate exposure were analysed by single-cell Ca2+ recording. In both cell lines, glutamate induced a single-peaked, non-oscillatory ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/383089a0
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  • 4
    Electronic Resource
    Electronic Resource
    Rupture of liver metastasis of malignant melanoma —A case of hepatic resection— (1991)
    Springer
    Surgery today 21 (1991), S. 480-484 
    Details
    ISSN: 1436-2813
    Keywords: malignant melanoma ; liver metastasis ; rupture ; hepatectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case is reported in which resection of the left lateral segment of the liver was performed for rupture of a metastatic malignant melanoma in an attempt to control hemorrhaging. The primary lesion was located in the skin of the head, and there were multiple metastases to the lung, liver and distant nodes. The patient, a 47-year-old woman, had been undergoing systemic chemotherapy for the disseminated disease, but she presented with intraabdominal bleeding from a metastatic nodule in the left lateral segment of the liver. An emergency operation was performed, and the immediate postoperative course was uneventful. She was discharged 10 days after the operation. The patient died, however, of hemorrhagic shock due to renewed intraabdominal bleeding on the 39th postoperative day. It is concluded from the above case that hepatic resection for a bleeding metastasis of malignant melanoma is a viable option even in patients with disseminated disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02470981
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  • 5
    Electronic Resource
    Electronic Resource
    Recurrent valvular pneumoperitoneum caused by a minute gastric ulcer —A case report— (1991)
    Springer
    Surgery today 21 (1991), S. 571-575 
    Details
    ISSN: 1436-2813
    Keywords: valvular pneumoperitoneum ; gastric ulcer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A rare case of valvular pneumoperitoneum is reported. A 49-year-old Japanese man underwent an emergency laparotomy under a tentative diagnosis of perforating panperitonitis on the 19th post-open heart surgery day. A large volume of free intraperitoneal gas was revealed, but no identification of gastrointestinal perforation. On the 17th postlaparotomy day, pneumoperitoneum recurred. On the 41st postalaparotomy day, a tiny gastric perforation was detected with an oral contrast medium. The patient died of liver failure due to serum hepatitis. The autopsy revealed a minute gastric ulcer scar 2 mm in diameter in the mucosa of the fornix, which was thought to have caused the valvular pneumoperitoneum. A literature review was made of 8 reports on 11 cases. In two cases of valvular pneumoperitoneum, the perforating site could not be found even during laparotomy. It is suggested that either gastrointestinal series or endoscopy must be carefully repeated in order to identify the perforating site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02470997
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  • 6
    Electronic Resource
    Electronic Resource
    Histometric analysis of the distal pancreas in pancreatic head cancer (1997)
    Springer
    Surgery today 27 (1997), S. 420-428 
    Details
    ISSN: 1436-2813
    Keywords: fibrosis ; islet of Langerhans ; B cell ; diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To clarify the histological status of the pancreas tail after pancreatoduodenectomy (PD), fibrosis, islets of Langerhans, and A, B, and D cells were examined histometrically in surgical cases of pancreatic cancer. The same investigations were also performed during an autopsy examination of the pancreas tail of survivors of surgery who had received either PD or total pancreatectomy with segmental autotransplantation (SAT). In the surgical cases, fibrosis and the islet percentage compared with nonpancreatic cancer cases were significantly higher while the B cell ratio was significantly lower. In addition, in pancreatic cancer patients, the fibrosis and islet ratio in the group with a blocked pancreatic duct were higher while the B cell ratio was lower than in the group with an open pancreatic duct. A direct relationship between the islet ratio and the degree of fibrosis, and an inverse relationship between the B cell ratio and the degree of fibrosis, were thus found. From the autopsy cases, the fibrosis progressed and the islet ratio increased following PD, but after SAT only the islet ratio increased compared to the time of surgery. The progression of fibrosis after PD thus suggests the presence of some problems in both the surgical method and postoperative management.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02385705
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  • 7
    Electronic Resource
    Electronic Resource
    An adult case of duodenal anomaly (1997)
    Springer
    Surgery today 27 (1997), S. 749-752 
    Details
    ISSN: 1436-2813
    Keywords: duodenum ; anomaly ; duodenal atresia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A distal gastrectomy reconstruction using the Billroth II procedure was performed for epigastralgia and liver dysfunction caused by a duodenal anomaly in an adult. Hypotonic duodenography revealed the duodenum to be obliterated at the junction of the second and third portion, while the third portion was joined to the first portion. Endoscopic retrograde cholangiopancreaticography (ERCP) and ultrasonography showed a normal construction of the common bile and pancreatic ducts, as well as gallstones. To prevent ingested food from the stomach from entering the obliterated second portion, a distal gastrectomy (Billroth II) was thus performed. The patient has remained asymptomatic for 4 years since surgery. A distal gastrectomy reconstructed by a gastrojejunostomy is thus considered to be an effective method for improving the symptoms caused by food stasis in the obliterated second portion of the duodenum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02384990
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  • 8
    Electronic Resource
    Electronic Resource
    Increased Urinary Excretion of Bilirubin Metabolites in Association with Hyperbilirubinemia After Esophagectomy (1998)
    Springer
    Surgery today 28 (1998), S. 1119-1123 
    Details
    ISSN: 1436-2813
    Keywords: Key Words: esophagectomy ; bilirubin metabolites ; hyperbilirubinemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950050298
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  • 9
    Electronic Resource
    Electronic Resource
    Papillary cystic neoplasm (PCN) of the pancreas with lymph node metastasis: Case report of a 77-year-ood woman and a review of 198 reported cases (1994)
    Springer
    Journal of hepato-biliary-pancreatic surgery 1 (1994), S. 413-418 
    Details
    ISSN: 1436-0691
    Keywords: pancreatic neoplasm ; papillary cystic neoplasm ; lymph node metastasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of papillary cystic neoplasm (PCN) of the pancreas in a 77-year-old woman, the oldest patient in the English literature, is reported. Distal pancreatectomy with regional lymphadenectomy was performed for the tumor in the pancreatic tail. Postoperative pathology examination revealed a metastatic lesion in one of the regional lymph nodes. This patient is well doing without recurrence 5 years after surgery. One hundred and ninety-eight cases of PCN, including the present case, have been reported in the English literature. The patients were aged from 2 to 77 years (mean, 25.8); there were 187 females and 11 males. Sixteen patients with metastasis, 22 with local invasion, and 3 with peritoneal dissemination were reported. Complete resection of the tumor was performed in 151 patients, including 6 with metastasis and 11 with local invasion. Only one patient died of recurrent tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02391105
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  • 10
    Electronic Resource
    Electronic Resource
    Recurrence of cancer in the heterotopically auto-transplanted caudal pancreas (1994)
    Springer
    Journal of hepato-biliary-pancreatic surgery 1 (1994), S. 583-588 
    Details
    ISSN: 1436-0691
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We performed segmental auto-transplantation of the caudal pancreas to the groin after total pancreatectomy and sufficiently preserved the endocrine functions of the pancreas in 20 patients with advanced pancreatic head cancer. Nineteen patients have died, and autopsies were permitted for 18 of these 19 patients. The autopsies were performed 49–922 (mean 404) days after surgery. Cancer cells were microscopically noted in the transplanted pancreas in 2 of 2 patients in whom cancer cells had been noted on the transected plane of the pancreas in the postoperative examination. Cancer cells were also noted in the transplanted pancreas in 10 of 16 patients whose transected plane had been free of cancer cells in the postoperative examination. In the surviving patient, the transplanted pancreas was removed 39 months after surgery, due to recurrence. Thus, the recurrence rate was 11/17 (64.7%). The site of recurrence was the proximal portion of the graft in 10 of these 11 patients. It is suggested that there were some precursor cells left in the transected portion of the transplanted pancreas which subsequently developed into cancer cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01211925
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