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  • 1
    Electronic Resource
    Electronic Resource
    ATP synthesis by mitochondria of brain synaptosomes (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 23 (1974), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1974.tb10761.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    ELONGATION OF MITOCHONDRIAL FATTY ACIDS DURING BRAIN DEVELOPMENT (1971)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 18 (1971), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Elongation of mitochondrial fatty acids was studied in whole brain samples from rats before, during and after the period of myelination. The mitochondria were isolated by centrifugation in a discontinuous sucrose gradient and incubated under N2 in a medium containing NADH, NADPH, ATP and acetyl-[1-14C]coenzyme A. Fatty acids were extracted, methylated and analysed by gas-liquid chromatography. A distinct pattern emerged in which brain mitochondria from rats undergoing myelination synthesized longer chain fatty acids preferentially, particularly C22:4. Mitochondria from brains of mature rats synthesized shorter chain fatty acids preferentially, mainly C18:0 and C20:4. We suggest that eicosamonoenoic acid (C22:1) is a precursor in vivo of nervonic acid (C24:1).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1971.tb09595.x
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  • 3
    Electronic Resource
    Electronic Resource
    THE EFFECT OF γ-AMINOBUTYRIC ACID ON BRAIN MITOCHONDRIAL ATP SYNTHESIS (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 23 (1974), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —Rat brain mitochondrial ATP synthesis was studied by measuring labeled orthophosphate incorporation into ADP to form ATP. GABA stimulates ATP synthesis, and this effect requires glutamate since with GABA alone little ATP is formed. The significance of this effect by GABA is unclear, but the mechanism may relate to induction of conformational change or chelation of cation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1974.tb04396.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Elongation of fatty acids in human brain tissue (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 20 (1973), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1973.tb12162.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Chain elongation of linoleic and linolenic acids by brain mitochondria (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 19 (1972), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1972.tb06228.x
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  • 6
    Electronic Resource
    Electronic Resource
    Corticosteroid and growth hormone secretion in patients treated with L-dopa (1970)
    Springer
    Journal of molecular medicine 48 (1970), S. 1454-1456 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Sekretion von Corticosteroiden und Wachstumshormon wurde in fünf Patienten mit Parkinsonscher Krankheit vor und während der Behandlung mit L-Dihydroxyphenylalanin (L-Dopa) untersucht. Gemessen wurden die 17-Hydroxycorticosteroide und 17-Ketosteroide in Harn und der Anstieg der 11-Hydroxycorticosteroide (11-OHCS) und das Serum Wachstumshormon während eines Insulinhypoglykämietests. Plasma 11-OHCS und Wachstumshormon-Sekretion waren vor der Behandlung mit L-Dopa bei allen Patienten im Normbereich. Während der Behandlung mit L-Dopa zeigten 3 der 5 Patienten einen geringeren Anstieg der Plasma 11-OHCS. Ein Patient hatte nach 4 Wochen Therapie mit L-Dopa überhaupt keinen Anstieg der Plasma 11-OHCS während der durch Insulin induzierten Hypoglykämie. Der durch die Hypoglykämie provozierte Anstieg des Wachstumshormons wurde von L-Dopa nicht beeinflußt. Diese vorläufigen Ergebnisse sind mit der Annahme eines adrenergen, die ACTH-Sekretion blockierenden Systems im Zentralnervensystem vereinbar.
    Notes: Summary Corticosteroid and growth hormone release were studied in 5 patients receiving L-dihydroxyphenylalanine (L-dopa) for the treatment of Parkinson's disease. Evaluation consisted of urinary steroid determinations and measurements of plasma 11-hydroxycorticosteroid (11-OHCS) and serum growth hormone responses to insulin hypoglycemia before and during treatment with L-dopa. No significant abnormality in plasma 11-OHCS or growth hormone secretion was detected in Parkinsonian patients before treatment. During treatment with L-dopa, 3 of 5 patients had a lower plasma 11-OHCS response to hypoglycemia than before treatment. One patient showed no plasma 11-OHCS rise at all after 4 weeks of L-dopa therapy. Growth hormone responses to hypoglycemia were not affected by administration of L-dopa. This preliminary study provides support for the hypothesis of a central adrenergic neural system inhibiting ACTH secretion in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484684
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Acetyl transport mechanisms. Involvement of N-Acetyl aspartic acid in de novo fatty acid biosynthesis in the developing rat brain (1968)
    Springer
    Experimental brain research 5 (1968), S. 267-273 
    Details
    ISSN: 1432-1106
    Keywords: De novo fatty acid synthesis ; Acetyl transport mechanisms ; N-acetyl aspartic acid ; Brain development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The incorporation into fatty acids of N-acetyl aspartic acid, labeled in the acetyl group, was investigated during brain growth and development. Parasagittal injection of the acetyl amino acid into rats of various ages resulted in maximum incorporation just before and during myelination, a period in which the endogenous N-acetyl aspartic acid increases rapidly. The results indicate that the only barrier to the uptake of this compound is at the blood-brain barrier. Gas liquid chromatographic analysis of the fatty acid methyl esters isolated by mild base hydrolysis showed that the labeled fatty acids were primarily the C16 and C18 long-chain acids. These results indicate that N-acetyl aspartic acid is actively involved in de novo fatty acid synthesis throughout growth and development of the brain. It is suggested that, in the brain, N-acetyl aspartic acid is a constituent of the acetyl transport system for extra-mitochondrial fatty acid synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235902
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    Paper (German National Licenses)
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