ISSN:
1573-2622
Keywords:
Aqueous humor
;
toxoplasma
;
cytomegalovirus
;
varicella zoster virus
;
herpes simplex virus
;
uveitis
;
diagnostic test
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Analysis of local intraocular antibody production is a valuable tool with which to confirm a suspected clinical diagnosis in uveitis. We have analysed paired serum and aqueous samples for the presence of specific antibodies against toxoplasma, cytomegalovirus, herpes simplex virus and varicella zoster virus. Of the patients retrospectively diagnosed as having toxoplasma chorioretinitis 75% had a positive antibody coefficient indicating specific antibody production in the eye. Local antibody production in the eye directed against CMV confirmed the suspected diagnosis of CMV retinitis in 50% of the AIDS patients investigated. So far we have not been able to demonstrate local antibody production against herpes simplex virus (26 samples tested). Two of three patients with acute retinal necrosis had a positive antibody coefficient against varicella zoster virus. Both of these patients had an even higher titer in the aqueous than in serum. Since the choice of therapy, in infectious uveitis, depends on the causative organisms, it is very important to confirm a suspected clinical diagnosis by means of aqueous humor analysis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00164835
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