ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Lactate dehydrogenase (LDH) and enzyme-linked immunosorbent assay (ELISA) haveattracted much attention recently for the evaluation of blood compatibility of biomaterials due totheir convenience and quantifiability. In this paper, the use of LDH and ELISA is described for insitu investigation of platelet behavior on biomaterial surfaces, including quantification of plateletadhesion and platelet activation, after suitable testing conditions have been established. Thematerial samples investigated in these tests included low temperature isotropic carbon (LTIC), Ti-Ofilms, and phosphorus- and aluminum-doped TiO2 films. The evaluation results show that thelowest platelet adhesion and activation are observed on phosphorus-doped TiO2 films while thehighest platelet adhesion and activation are observed on LTIC. In addition, conventional plateletadhesion experiments were performed for comparison, and yielding similar evaluation results asLDH and ELISA. It is suggested that LDH and ELISA tests can be successfully applied to evaluatethe blood compatibility of biomaterials and can show many advantages, such as quantification,reliability and objectivity, compared with conventional platelet adhesion test
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.841.pdf
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