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  • 1
    Electronic Resource
    Electronic Resource
    Generation of cytotoxic ef fector cells against human melanoma (1995)
    Springer
    Cancer immunology immunotherapy 40 (1995), S. 397-409 
    Details
    ISSN: 1432-0851
    Keywords: Key words. Generation ; Lymphocytes ; Melanoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Metastatic or tumor-draining lymph nodes from six of nine melanoma patients undergoing lymph node dissection for metastatic melanoma generated cytotoxic T cells against autologous melanoma when these lymph node cells were treated by in vitro sensitization and recombinant interleukin-2 (IL-2). During the initial lymphocyte culture (2–6 weeks), cross-reactivity with autologous tumor cells, K562 and Daudi cells was usually noted. Cold-target inhibition assay with K562 and Daudi showed K562/Daudi-associated antigens on melanoma cells. During the later phase of lymphocyte culture with repeated in vitro sensitization (over 6–10 weeks), cytotoxicity was noted against autologous and allogeneic melanoma cells but not against K562, Daudi cells or autologous fibroblasts. Repeated in vitro sensitization resulted in the selection of specific cytotoxic lymphocytes against melanoma. Cold-target inhibition assay with autologous and allogeneic melanoma cells revealed shared and individual antigens. Using blocking monoclonal antibodies, MHC-restricted killing was noted in the autologous system. Further, both the autologous and allogeneic systems could be mediated through adhesion molecules such as ICAM-1 and LFA-3 on melanoma cells and LFA-1 on T cells. This study suggests that a constellation of cytotoxic effector cells and melanoma-associated antigens may be pivotal in tumor killing. Thus, future adoptive immunotherapy should modulate and enhance this complex interaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01525391
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  • 2
    Electronic Resource
    Electronic Resource
    Identification and Genetic Studies of the Inhibition of Dominant Male Sterility in Brassica napus (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 113 (1994), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: By transferring dominant male sterility (DMS), caused by the gene Ms, to genotypes with various types of cytoplasm 12 DMS lines were developed and a number of crosses made between the DMS lines and other genotypes of Brassica napus. During the course of this population improvement programme, 16 genotypes were identified as having the capacity to restore the fertility of F1 plants with the Ms gene. According to pedigree analysis, the inhibitory gene in those lines probably originated from a few genotypes from Australia and Germany. In further studies the inheritance of the sterility inhibition was determined, providing definite evidence that dominant male sterility and its inhibition in B. napus are controlled by two dominant interacting genes rather than by multiple alleles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0523.1994.tb00726.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    [Tris(2-pyridyl-κN-methyleneamino-κN-ethyl)amine-κN]manganese(II) diperchlorate (1999)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 55 (1999), S. 742-744 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270198017624
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  • 4
    Electronic Resource
    Electronic Resource
    Microinstabilities associated with a high Mach number, perpendicular bow shock (1984)
    Springer
    Space science reviews 37 (1984), S. 63-109 
    Details
    ISSN: 1572-9672
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The instabilities associated with a high Mach number perpendicular shock are reexamined in light of recent enhanced understanding of the Earth's bow shock. The insights provided by both the ISEE observations and hybrid simulations are reviewed and subsequently incorporated into the instability analyses. The discussion of the instabilities is divided according to their location in the shock layer. In the regions in front of and at the shock transition the cross-field instabilities are subdivided into low frequency modes (e.g. ion-ion streaming, kinetic cross-field streaming, drift lower hybrid instabilities) and high frequency modes (electron cyclotron drift, ion sound and electron whistler instabilities). Further downstream various ion ring-like and anisotropy driven instabilities are considered. In each case the instability analysis is reviewed and recent developments are emphasized. Implications of these results concerning the wave signatures and plasma heating and acceleration are also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00213958
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    Paper (German National Licenses)
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