ISSN:
1432-0703
Source:
Springer Online Journal Archives 1860-2000
Topics:
Energy, Environment Protection, Nuclear Power Engineering
,
Medicine
Notes:
Abstract The aim of the study was to investigate the effect of 10 ppm sulfur dioxide (SO2) exposure on visual evoked potentials (VEPs), thiobarbituric acid reactive substances (TBARS), and the activities of Cu,Zn superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in diabetes mellitus. Forty healthy male albino rats, aged 3 months, were divided into four equal groups: control (C), sulfur dioxide + control (CSO2), diabetic (D), and sulfur dioxide + diabetic (DSO2) groups. Experimental diabetes mellitus was induced by IV injection of alloxane monohydrate in a dose of 50 mg/kg body weight. Ten ppm sulfur dioxide was administered to the animals of sulfur dioxide–exposed groups in an exposure chamber for 1 h/day × 7 days/week × 6 weeks while control and diabetic groups were exposed to filtered air in the same condition. SO2 exposure, though markedly decreasing retina CAT and GSH-Px activities, significantly increased retina Cu,Zn-SOD activity in the diabetic and nondiabetic groups. In contrast to SO2-related increase in the activity of Cu,Zn-SOD, decrease in GSH-Px activity was observed in the brain of those groups. Brain CAT activity was unaltered. SO2 exposure caused the significant elevation in brain TBARS levels of CSO2 and DSO2 groups, whereas only in the retina TBARS level of the CSO2 group. SO2 exposure caused the significant prolongations of P1, N1, P2, and P3 components of VEPs in the nondiabetic and all components of VEPs in the diabetic groups. SO2 exposure also resulted in significant amplitude reductions in both experimental groups.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002440010103
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