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  • 1
    Electronic Resource
    Electronic Resource
    Effects of TMK688, a novel anti-allergic drug, on allergic nasal obstruction and exudative responses in sensitized guinea pigs (1997)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 356 (1997), S. 815-819 
    Details
    ISSN: 1432-1912
    Keywords: Key words Rhinitis ; Leukotrienes ; 5-Lipoxygenase ; Histamine ; TMK-688 ; Anti-allergic Drug
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract TMK688 (1-[{5’-(3”-methoxy-4”-ethoxy-carbonyloxyphenyl)-2’,4’-pentadienoyl} aminoethyl]-4-diphenylmethoxypiperidine) is being developed as an orally effective antiallergic drug having both 5-lipoxy-genase inhibitory activity and anti-histamine activity (Shizawa et al. 1996; Tohda et al. 1997). The efficacy of TMK688 against allergic rhinitis was examined in passively sensitized guinea pigs. TMK688 inhibited the increase in intranasal resistance following antigen challenge at doses of 1 and 3.2mg/kg p.o. The allergic nasal obstruction was also suppressed by 10mg/kg i.v. of FPL-55712, a peptide leukotriene receptor antagonist, but not by 3.2mg/kg i.v. pyrilamine, a histamine H1 receptor antagonist, or by 10mg/kg p.o. of ketotifen, an anti-allergic drug having anti-histamine activity, suggesting that the nasal obstruction was caused by leukotrienes. Following antigen challenge, the intranasal release of leukotrienes B4 and C4, and histamine increased in passively sensitized guinea pigs. TMK688 tended to suppress the increase in immunoreactive leukotrienes B4 and C4 in the nasal lavage fluid at a dose of 1mg/kg p.o., and significantly inhibited the increase at 3.2mg/kg. The brilliant blue dye leakage following antigen challenge from the blood stream into the na-sal cavities was significantly inhibited by not only TMK688 and FPL-55712 but also pyrilamine, suggesting that the allergic dye leakage was caused cooperatively by leukotrienes and histamine. However, keto-tifen showed no significant suppression of the dye leakage even at 10mg/kg p.o., although this drug inhibited the histamine-induced dye leakage at far lower doses (0.1mg/kg p.o. or higher) in unsensitized guinea pigs. Therefore, histamine is not necessarily the major mediator of allergic dye leakage in our experiment. These findings demonstrate that TMK688 may be superior to antihistamines as a therapeutic agent for allergic rhinitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005122
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Output feedback stabilizability and stabilization algorithms for 2D systems (1994)
    Springer
    Multidimensional systems and signal processing 5 (1994), S. 41-60 
    Details
    ISSN: 1573-0824
    Keywords: 2D system ; polynomial matrices ; unilateral equation ; Bezout equation ; Gröbner basis ; module ; output feedback ; stabilizability ; stabilization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract Alternative methods are proposed for test of output feedback stabilizability and construction of a stable closed-loop polynomial for 2D systems. By the proposed methods, the problems can be generally reduced to the 1D case and solved by using 1D algorithms or Gröbner basis approaches. Another feature of the methods is that their extension to certain specialnD (n〉2) cases can be easily obtained. Moreover, the “Rabinowitsch trick,” a technique ever used in showing the well-known Hilbert's Nullstellensatz, is generalized in some sense to the case of modules over polynomial ring. These results eventually lead to a new solution algorithm for the 2D polynomial matrix equationD(z, w)X(z, w)+N(z, w)Y(z, w)=V(z, w) withV(z, w) stable, which arises in the 2D feedback design problem. This algorithm shows that the equation can be effectively solved by transforming it to an equivalent Bezout equation so that the Gröbner basis approach for polynomial modules can be directly applied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00985862
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Bilateral polynomial matrix equations in two indeterminates (1990)
    Springer
    Multidimensional systems and signal processing 1 (1990), S. 363-379 
    Details
    ISSN: 1573-0824
    Keywords: Polynomial matrices ; Bilateral equations ; 2-D systems ; 2-D polynomial ; skew primeness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract Two special cases of the bilateral 2-D polynomial matrix equationDU +VN=C whenC=I andC=αI withα being a Ω-stable 2-D polynomial, which are related respectively to deadbeat and asymptotic control problems of 2-D systems, are first considered. By generalizing the concepts of factor coprimeness, zero coprimeness and zero skew primeness in the 2-D polynomial ring to the ring of causal Ω-stable 2-D rational functions, a constructive solution of these two problems mentioned is proposed. Based on these results, we derive a solvability condition for the bilateral equiation whereC is a general 2-D polynomial matrix. The general solutions are investigated as well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01937366
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    Paper (German National Licenses)
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