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  • 1
    Electronic Resource
    Electronic Resource
    The diagnostic significance of immunoglobulin and fibrin deposition in lichen planus (1975)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 93 (1975), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Direct immunofluorescent (IF) staining was performed on biopsy specimens from fifty-three patients with active lichen planus. In fifteen of these cases uninvolved skin sites were also examined. Globular or cytoid body-like deposits of immunoglobulins, mainly IgM, were detected in forty-six of the active lesions, and in half the uninvolved skin biopsies. The deposition of fibrin in the papillary dermis and around follicular structures was seen only in the active lichen planus papules.The significance of these findings was assessed by comparison with the IF results obtained in 252 biopsies from various cutaneous disorders, stained by the same technique during the period of this study. Although the presence of immunoglobulin cytoid bodies and fibrin was found to be highly characteristic of lichen planus, these findings were not specifically diagnostic. Morphologically identical deposits were seen not infrequently in lupus erythematosus and in eczema. Active lesions of dermatitis herpetiformis, erythema multiforme and other rare dermatoses also showed these cytoid body-like immunoglobulin deposits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1975.tb06470.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Secondary syphilis: a clinico-pathological review (1975)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 93 (1975), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The histological appearances found in biopsies from fifty-seven patients with secondary syphilis have been correlated with the clinical morphology of the eruptions. Considerable variation of histological pattern was encountered, and the frequency with which some of the classically described changes were found to be absent or inconspicuous is stressed. Of particular interest were the findings that, in nearly one-quarter of the biopsies, plasma cell infiltration was either absent or very sparse, and that vascular damage was seen in less than half. Where present, the vessel changes were almost entirely confined to swelling of the endothelial cells. Proliferation of the endothelial cells was most uncommon.The epidermis was very frequently involved in the inflammatory process. Exocytosis, spongiosis, parakeratosis, and acanthosis were the most frequent changes. No consistent histological difference between papular and papulo-squamous lesions could be found but macular lesions demonstrated more superficial and less intense dermal infiltration as well as less severe epidermal involvement.In late secondary lesions, the infiltrate became granulomatous, but in other respects the duration of the exanthem could not be correlated with the pathology.The differential diagnosis from pityriasis lichenoides and other inflammatory dermatoses is discussed and the value of histopathology in the diagnosis of secondary syphilis is emphasized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1975.tb06476.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacology and Treatment The treatment of idiopathic hyperhidrosis by glycopyrronium bromide and tap water iontophoresis (1974)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 91 (1974), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A method of treating idiopathic hyperhidrosis usitig direct current iontophoresis is described. Employing a solution of glycopyrronium bromide, such treatment produces prolonged periods of suppression of palmar and plantar hyperhidrosis but only occasionally do useful periods of dryness result from treatment of axillary hyperhidrosis.Tap water iontophoresis can also be used to produce sweat suppression but its effects are generally less satisfactory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1974.tb06722.x
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  • 4
    Electronic Resource
    Electronic Resource
    TREATMENT OF PSORIATIC NAIL DYSTROPHY (1972)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 86 (1972), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY.— A rapid, relatively painless method of treating psoriatic dystrophy of finger nails is described using a “Porton type” of needleless injector. Following treatment, 21 of 27 nails showed satisfactory return of normal appearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1972.tb01897.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Epidermal antigens in lichen planus (1975)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 92 (1975), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The loss of intercellular and basement membrane amigens has been associated with the development of epidermal cell dysplasia and ncoplasia. The antigenic components of the epidermis have been investigated in lichen planus, lupus erythematosus and eczema, using pemphigoid and pemphigus sera by the indirect immunofluorescent staining method. In areas of active lichen planus there was extensive reduction or complete absence of basement membrane antigen. Intercellular antigen was preserved in lichen planus although in some damaged retc ridges it appeared to be reduced. Both these antigens were well preserved in lupus erythematosus and eczema. Loss of epithelial antigens is therefore not confined to the development of neoplasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1975.tb03142.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Immunoglobulin and complement deposits in the skin in inflammatory facial dermatoses—an immunofluorescence study (1974)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 91 (1974), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Biopsy material from ninety-one cases of inflammatory facial dermatoses was stained by the direct immunofluorescence method. The presence of immunoglobulins and complement in a distinct basement membrane band was seen only in lupus erythematosus. Negative results were found in thirty five cases of rosacea.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1974.tb12897.x
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Granuloma annulare and necrobiosis lipoidica treated by jet injector (1975)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 93 (1975), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A Porto-jet injector was employed to treat forty-five cases of granuloma annulare and five cases of necrobiosis lipoidica with triamcinolone acetonide or sterile normal saline. Complete clearance of granuloma annulare lesions was achieved in nearly 70% of those receiving triamcinolone and in 44% with saline. Inadequate penetration of lesions was responsible for a number of failures. The rate of recurrence after treatment was high but retreatment was usually successful. In three cases of necrobiosis lipoidica complete resolution occurred, while in one, partial improvement was obtained. No serious complications of this type of treatment were observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1975.tb06481.x
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  • 8
    Electronic Resource
    Electronic Resource
    The junctional zone beneath migrating epidermis (1975)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 92 (1975), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The changes that take place in skin explants in vitro at the interface between migrating epidermal cells and dermis have been examined by light and electron microscopy and by immunofluorcscent antibody techniques. In the first 24 h epidermal cell migration occurred in the absence of any of the usual components of this junctional zone. After 48 h of incubation antigenic determinants of the basal zone were detected and basal lamina was demonstrated ultrastructurally. It is proposed that migrating epidermal cells do not need a complex and specialized junctional zone and that these cells are themselves responsible for the elaboration of new basal lamina.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1975.tb03081.x
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Intradermal triamcinolone treatment of nail dystrophies (1973)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 89 (1973), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: With a needleless injector (Port-O-Jet), triamcinolone acetonide can readily be injected into the area of the finger-nail matrix, through the posterior nail fold. 100 cases of various nail dystrophies have been treated in this way.Dystrophies involving the nail matrix have been found to resolve substantially in the majority of cases. Onycholysis was found to improve occasionally, but generally relapsed rapidly. However, when onycholysis was associated with matrix abnormalities more consistent and prolonged remissions of the onycholytic areas occurred.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1973.tb02956.x
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  • 10
    Electronic Resource
    Electronic Resource
    Mucinous syringometaplasia mimicked by a clear cell hidradenoma with mutinous change (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 18 (1991), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An adnexal tumor with features of both clear cell hidradenoma and mucinous syringometaplasia is reported. The lesion occurred as a solitary, asymptomatic, slow growing nodule of 6-months duration on the anterior neck of a 55-year-old woman. Serous fluid could be expressed from a central skin opening. Histologically, there was a squamous-lined imagination with foci of mucin-ladcn cells. A ductal component with a variable admixture of mucinous cells merged with a nearby clear cell hidradenoma. Because clinicopathologic similarities exist between mucinous syringometaplasia and clear cell hidradenoma with mucinous change, thorough sectioning of mucinous syringo-metaplasia-like lesions is necessary to exclude an associated sweat gland neoplasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1991.tb01546.x
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