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  • 1
    Electronic Resource
    Electronic Resource
    Effects of oxprenolol on the airways of normal and bronchitic subjects (1976)
    Springer
    European journal of clinical pharmacology 9 (1976), S. 259-263 
    Details
    ISSN: 1432-1041
    Keywords: Oxprenolol ; airways obstruction ; beta-2 blockade ; statistical methods
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a double blind trial in 11 control subjects and 12 bronchitic patients against an inert control oxprenolol produced significant worsening in airways obstruction in 6 control and in 7 patients. There was marked individual variation in response and no way was found to predict the susceptible subjects. Objective measurement of indices of airways obstruction and the effect of oxprenolol on them is essential where there is significant respiratory impairment. Great care must continue to be exercised since a significant proportion of bronchitic patients will be adversely affected by this drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561658
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Respiratory function measurements in clinical pharmacological studies including an assessment of the area under the MEFV curve as a new parameter in chronic bronchitic patients (1988)
    Springer
    European journal of clinical pharmacology 34 (1988), S. 277-281 
    Details
    ISSN: 1432-1041
    Keywords: aminophylline ; bronchitis ; chronic obstructive airways disease ; respiratory function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have assessed the value of the area under the MEFV curve (AUC) as an index of respiratory function in chronic bronchitis and compared it with PFR, FEV1, FVC, volume at 75% PFR (V75), V50, V25, F50 and F75. The reproducibility of these parameters was tested in 10 normal subjects and 10 patients with chronic bronchitis. The FVC was the most reproducible while the coefficient of variation for the AUC was the same as for the other MEFV curve indices. The sensitivity (percentage change on bronchodilatation after intravenous aminophylline) of the above measurements was also tested in a further nine patients with chronic bronchitis. The AUC was much more sensitive to bronchodilatation than any of the other measurements. Therefore although the AUC was less reproducible than simple spirometric indices, it was more sensitive to bronchodilatation by a greater factor. This probably outweights its poor reproducibility and AUC would therefore seem to be a useful new index of bronchodilatation in chronic bronchitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00540956
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Assessment of a combination of doses of fenoterol and ipratropium suitable for a single metered-dose aerosol (1979)
    Springer
    European journal of clinical pharmacology 16 (1979), S. 97-100 
    Details
    ISSN: 1432-1041
    Keywords: bronchodilator ; ipratropium ; fenoterol ; combination ; chronic bronchitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary This paper reports a study of the bronchodilator effects of doses of the beta2 agonist fenoterol and the muscarinic blocker ipratropium suitable for administering in combination as a standard dose of two discharges from a single metereddose pressurised aerosol. In 12 middle-aged bronchitics who had already been shown to respond to both types of drug the combination was almost always a little (6% on average) more effective than either drug singly. It is possible that an equal or better effect could have been obtained if fenoterol or perhaps ipratropium had been given alone in an individually determined maximally effective dose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00563114
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The influence of theophylline on maximal response to salbutamol in severe chronic obstructive pulmonary disease (1982)
    Springer
    European journal of clinical pharmacology 22 (1982), S. 389-393 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; salbutamol ; bronchitis ; maximal response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have previously shown that inhaled salbutamol further increases the bronchodilator response after the maximum effect of theophylline has been obtained in patients with severe chronic bronchitis. We now report the results of adding maximally effective doses of theophylline to the maximum response obtainable from salbutamol in ten of these patients. We constructed dose response curves to ensure maximum possible effect from salbutamol. Response plateaus (in nine out of ten patients) were achieved with cumulative doses of between 200 µg and 3,000 µg salbutamol and there was a significant response (p〈0.05) in every subject: the mean FVC response was 1.1 l (ranging from 0.5 to 1.8 l) and the mean FEV1 response was 0.4 l (ranging from 0.1 to 0.8 l). Theophylline, in their previously determined maximally effective doses, produced statistically significant (p〈0.05) small further increases in both FVC (0.2 to 0.6 l) and FEV1 (0.1 to 0.6 l) in four patients only. The other six did not respond. In patients classified as chronic bronchitics there is clearly a wide variation in response to bronchodilators and a surprising degree of reversibility can be achieved. But because of this variation in response, conventional drug doses may be too small in some cases. Ideally, each bronchodilator should be prescribed after some form of individual dose response studies. Although this acute study shows little or no benefit in the height of the bronchodilator response the usefulness of this combination can only really be decided after similar studies including the duration of effect in long term administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542540
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    Paper (German National Licenses)
    Fulltext
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