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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 40 (1995), S. 2192-2196 
    ISSN: 1573-2568
    Keywords: esophagus ; stricture ; dysphagia ; accuracy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract There are many opinions as to the accuracy of a patient's subjective localization of an obstructing esophageal lesion. However, there are few studies specifically examining this issue. Over a 35-month period, all patients evaluated by our gastroenterology service undergoing endoscopy for dysphagia were prospectively identified. The patient's subjective localization for the level of obstruction was evaluated by an investigator blinded to the results of prior barium esophagography and recorded on a schematic of the bony skeleton. At the time of endoscopy, the most proximal level of the obstructing lesion was documented. In all, 139 patients with dysphagia and an esophageal stricture were evaluated. Barium esophagograms were performed prior to endoscopy in all but nine patients (6.5%). The most common lesions causing dysphagia were carcinoma (34.5%), gastroesophageal reflux disease (22.3%), and a Schatzki's ring (15.8%). The level of obstruction was localized exactly in 30 patients (21.6%), within ±2 cm in 72 (52%), and within ±4 cm in 31 additional patients (74%). Eight patients (15%) with a distal esophageal lesion localized the obstruction to the proximal esophagus, whereas only two patients (5%) with a lesion in the proximal esophagus localized the level of obstruction to the distal esophagus. Overall, patients with distal obstructing lesions were more likely to have referral 〉6 cm proximally than proximal lesions with referral to the distal esophagus (P=0.003). There were no significant differences in accuracy based on the cause of dysphagia. In conclusion, a patient's subjective localization of the level of an esophageal stricture is highly accurate. Patients appear to be most accurate in localizing proximal rather than distal lesions.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-2568
    Keywords: BLEEDING ; HEMORRHAGE ; NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; ASPIRIN ; DIVERTICULOSIS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the association between nonsteroidalantiinflammatory drug (NSAID) use and uppergastrointestinal bleeding (UGIB) and lowergastrointestinal bleeding (LGIB), we performed aprospective case-control study at a large inner-cityhospital over a 28-month period evaluating 461consecutive patients hospitalized for UGIB and 105 withLGIB. During the same period, 1895 in-patients evaluatedby our gastroenterology consultative service served ascontrols. At the time of initial evaluation, allpatients were asked about the use of any prescription orover-the-counter NSAID product within one week of admission. Endoscopic examination was performedin most patients with bleeding. NSAID use was almostequivalent in patients with UGIB and LGIB (60%) andsignificantly greater than controls [34%; P 〈 0.001; odds ratio (OR) 3.0; 95% CI, 2.4-3.6]. The age,race, and gender adjusted risk for LGIB associated withNSAID use was significant [adjusted OR (AOR) 2.6; 95% CI1.7-3.9], although less than UGIB (AOR 3.2; P = 0.34). The risk associated withdiverticular bleeding (N = 53, AOR 3.4; 95% CI 1.9-6.2)was higher than duodenal ulcer bleeding although notsignificantly (N = 97, AOR 3.0). We conclude that NSAIDuse is strongly associated with LGIB and from lesionsnot considered associated with mucosal ulceration suchas diverticulosis.
    Type of Medium: Electronic Resource
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