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  • 1
    Electronic Resource
    Electronic Resource
    Cytokeratin 20 expression by non-invasive transitional cell carcinomas: potential for distinguishing recurrent from non-recurrent disease (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 27 (1995), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Although approximately 50% of patients with non-invasive (Ta) papillary transitional cell carcinoma show no recurrence of their disease, current histopathological approaches cannot distinguish this sub-group from those patients in whom the disease will recur. In this 5 year retrospective study, we have shown that cytokeratin 20 (CK20) was expressed in 19 of 29 (65.5%) of non-invasive papillary tumours of grades 1 or 2. CK20 expression patterns were predictive of disease non-recurrence in a sub-group of eight patients, representing 51.7% of patients with non-recurrent disease. In normal bladder mucosa, CK20 expression was restricted to the terminally-differentiated superficial cell. In eight CK20-positive tumours which showed no recurrence at 5 years, CK20 expression was either restricted to, or most intense in, the luminal cells of the papillae. This pattern of expression was not seen in any of the 15 tumours from the recurrent group. Disruption of normal CK20 expression was highly significantly correlated with recurrent tumours. These results suggest that changes in the expression of differentiation-associated antigens, such as CK20, may be useful in predicting benign versus malignant behaviour and may, therefore, be useful in defining treatment strategies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1995.tb00025.x
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  • 2
    Electronic Resource
    Electronic Resource
    Tumor lysis syndrome following hemi-body irradiation for metastatic breast cancer (2000)
    Springer
    Annals of oncology 11 (2000), S. 1349-1351 
    Details
    ISSN: 1569-8041
    Keywords: breast cancer ; radiotherapy ; tumor lysis syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tumor lysis syndrome (TLS) is a rare serious acute complication of cancertherapy, reported mainly following chemotherapy in patients with large tumorload and chemosensitive disease. These are mainly patients with non-Hodgkin'slymphoma, leukemia and rarely in solid tumors. It is less frequently describedafter radiotherapy for lymphoid and hematological malignancies. TLS followingradiotherapy for solid tumors is a very rare complication. In thisreport/review we describe a seventy-three-year-old male patient withprogressive metastatic carcinoma of the breast to the lungs, liver and bone.He was referred for radiotherapy because of generalized bony pains. Thepatient was planned for sequential hemi-body irradiation starting with themore symptomatic upper half body. After premedication, he was given 8.5 Gy tothe mid point at the maximum chest separation with anterior lung attenuatorlimiting uncorrected lung dose to 6.15 Gy. A further 3.5 Gy electron boost tothe fungating breast tumor was given to the 100%. Forty-eight hours after irradiation he developed hyperkalemia,hyperphosphatemia, hyperuricemia, hypocalcemia and renal failure. Theseclinical and biochemical changes are typical of tumor lysis syndrome (TLS).Despite hydration, and treating the hyperuricemia, the patient developed comaand died eight days after irradiation. The prophylaxis and management of TLS and in high-risk patients aredescribed to avoid this frequently fatal complication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008347226743
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  • 3
    Electronic Resource
    Electronic Resource
    Aqueous iron-sulfur systems in rice field soils of Louisiana (1972)
    Springer
    Plant and soil 36 (1972), S. 251-260 
    Details
    ISSN: 1573-5036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary A phase diagram of an aqueous iron-sulfur system constructed from thermodynamic data for initial concentrations of 100 ppm H2S and 100 ppm Fe permitted us to predict that the principal precipitate found in the Eh - pH range of flooded Louisiana rice paddys would be FeS2. Analysis of precipitates formed in the laboratory at Eh and pH levels simulating paddy conditions showed that both FeS2 and FeS were present; however more FeS than predicted was actually precipitated in the FeS2 field of dominance. A multiparameter diagram for an aqueous system was constructed relating equilibrium iron concentration, Eh, pH and the equilibrium H2S concentration (that H2S which is in equilibrium with precipitated sulfides). It was demonstrated from the diagram and associated thermodynamic equations that the H2S⇌FeS2 equilibrium predicts theoritical values of H2S in agreement with experimental values of H2S from rice paddy soil samples8.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01373480
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  • 4
    Electronic Resource
    Electronic Resource
    Aqueous iron-sulfur systems in rice field soils of Louisiana (1972)
    Springer
    Plant and soil 36 (1972), S. 251-260 
    Details
    ISSN: 1573-5036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary A phase diagram of an aqueous iron-sulfur system constructed from thermodynamic data for initial concentrations of 100 ppm H2S and 100 ppm Fe permitted us to predict that the principal precipitate found in the Eh - pH range of flooded Louisiana rice paddys would be FeS2. Analysis of precipitates formed in the laboratory at Eh and pH levels simulating paddy conditions showed that both FeS2 and FeS were present; however more FeS than predicted was actually precipitated in the FeS2 field of dominance. A multiparameter diagram for an aqueous system was constructed relating equilibrium iron concentration, Eh, pH and the equilibrium H2S concentration (that H2S which is in equilibrium with precipitated sulfides). It was demonstrated from the diagram and associated thermodynamic equations that the H2S⇌FeS2 equilibrium predicts theoritical values of H2S in agreement with experimental values of H2S from rice paddy soil samples8.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01373480
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  • 5
    Electronic Resource
    Electronic Resource
    OnS-closed spaces (1991)
    Springer
    Acta mathematica hungarica 57 (1991), S. 11-14 
    Details
    ISSN: 1588-2632
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01903797
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  • 6
    Electronic Resource
    Electronic Resource
    Some kinetic studies on ribonucleosides degradation by extracts of penicillium citrinum (1991)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 11 (1991), S. 227-233 
    Details
    ISSN: 0138-4988
    Keywords: Life Sciences ; Life Sciences (general)
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Cell-free extracts of 3-4 days old mats of nitrate-grown Penicillium citrinum catalyze the hydrolytic cleavage of the N-glycosidic bonds of inosine, guanosine and adenosine optimally at pH 4, 0.1 M citrate buffer. The same extracts catalyze the hydrolytic deamination of cytidine at a maximum rate in 0.08 M Tris-acetate buffer pH 6.5, 40°C and 50°C were the most suitable degrees for purine nucleoside hydrolysis and cytidine deamination, respectively. The incubation of the extracts at 60°C, in the absence of cytidine caused a loss in the deaminating activity, while freezing and thawing had no effect on both activities. The deaminating activity seems to be cytidine specific as neither cytosine, adenine, adenosine nor guanosine could be deaminated. Uridine competively inhibited this activity, while ammonia had no effect. The apparent Km value of this enzyme for cytidine was 1.57×10-3M and its Ki value for uridine was 7.8×10-3M. The apparent Km values of the N-glycosidic bond cleaving enzyme for inosine, guanosine and adenosine were 13.3, 14.2 and 20×10-3 M, respectively.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/abio.370110310
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