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  • 1
    Digitale Medien
    Digitale Medien
    Abnormalities of IgA1 production in IgA nephropathy (2002)
    Oxford, UK : Blackwell Science Pty
    Nephrology 7 (2002), S. 0 
    Details
    ISSN: 1440-1797
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: SUMMARY: IgA nephropathy (IgAN) is characterized by the mesangial deposition of polymeric IgA1 (pIgA1). The original view that this pIgA1 is derived from the mucosal immune system can no longer be sustained. Studies of duodenal mucosa and marrow indicate increased production of pIgA1 in the marrow and decreased production in the mucosa. These changes are consistent with immunization studies showing exaggerated and prolonged pIgA responses to systemic immunization, and reduced mucosal responses to mucosal neoantigens. However, the IgA1 and IgG systemic responses to mucosal antigen are increased in IgAN, a finding consistent with impairment in oral tolerance, the process by which systemic immune responses to mucosal antigen challenge are normally suppressed. Both IgA1 production and the induction of oral tolerance are under T-cell control. T-cell populations involved in these processes include γδ T cells, Tr cells and T-helper (Th)3 cells; cytokines with a key role in the control of IgA production include interleukin (IL)-10 and transforming growth factor (TGF)-β. There is evidence of abnormal γδ T-cell V region usage in both mucosa and marrow in IgAN. Increased expression of relevant cytokines has also been reported in circulating T cells in IgAN. The increased O-glycosylation of circulating IgA1 in IgAN may also be further evidence of a shift in the production of mucosal-type pIgA1 from the mucosa to marrow. These findings suggest that the specific lymphocyte homing mechanisms that normally maintain oral tolerance and control the site of IgA production require further study in IgAN.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1440-1797.7.s3.4.x
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  • 2
    Digitale Medien
    Digitale Medien
    Abnormalities of IgA1 production in IgA nephropathy (2002)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 7 (2002), S. 0 
    Details
    ISSN: 1440-1797
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: SUMMARY: IgA nephropathy (IgAN) is characterized by the mesangial deposition of polymeric IgA1 (plgA1). the original view that this plgA1 is derived from the mucosal immune system can no longer be sustained. Studies of duodenal mucosa and marrow indicate increased production of plgA1 in the marrow and decreased production in the mucosa. These changes are consistent with immunization studies showing exaggerated and prolonged plgA responses to systemic immunization, and reduced mucosal responses to mucosal neoantigens. However, the IgA1 and IgG systemic responses to mucosal antigen are increased in IgAN, a finding consistent with impairment in oral tolerance, the process by which systemic immune responses, to mucosal antigen challenge are normally suppressed. Both IgA1 production and the induction of oral tolerance are under T-cell control. T-cell populations involved in these processes include γδ T cells, Tr cells and T-helper (Th)3 cells; cytokines with a key role in the control of IgA production include interleukin (IL)-10 and transforming growth factor (TGF)-β. There is evidence of abnormal γδ T-cell V region usage in both mucosa and marrow in IgAN. Increased expression of relevant cytokines has also been reported in circulating T cells in IgAN. the increased O-glycosylation of circulating IgA1 in IgAN may also be further evidence of a shift in the production of mucosal-type plgA1 from the mucosa to marrow. These findings suggest that the specific lymphocyte homing mechanisms that normally maintain oral tolerance and control the site of IgA production require further study in IgAN.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1797.2002.tb00518.x
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  • 3
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    Unbekannt
    Cup and Shakers (1922)
    Washington, D.C. : Periodicals Archive Online (PAO)
    Arts Education Policy Review. 24 (1922:May-1923:Apr.) 40 
    Details
    ISSN: 1063-2913
    Thema: Kunstgeschichte
    Notizen: CONVENTIONAL
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:3091-1922-024-00-000008
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  • 4
    facet.materialart.
    Unbekannt
    Salt Shaker (1922)
    Washington, D.C. : Periodicals Archive Online (PAO)
    Arts Education Policy Review. 24 (1922:May-1923:Apr.) 115 
    Details
    ISSN: 1063-2913
    Thema: Kunstgeschichte
    Notizen: CONVENTIONAL
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:3091-1922-024-00-000033
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  • 5
    facet.materialart.
    Unbekannt
    Marmalade Jar, Coffee Cup, Salt and Tea Caddy (1922)
    Washington, D.C. : Periodicals Archive Online (PAO)
    Arts Education Policy Review. 24 (1922:May-1923:Apr.) 148 
    Details
    ISSN: 1063-2913
    Thema: Kunstgeschichte
    Notizen: CONVENTIONAL
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:3091-1922-024-00-000046
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  • 6
    Digitale Medien
    Digitale Medien
    Anticholinergic serum levels and cognitive performance (1990)
    Springer
    European archives of psychiatry and clinical neuroscience 240 (1990), S. 28-33 
    Details
    ISSN: 1433-8491
    Schlagwort(e): Anticholinergic ; Dementia ; Psychopharmacology ; Geriatrics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Integrity of central cholinergic neurotransmission is essential for adequate cognitive functioning. Many psychotherapeutic medications have anticholinergic side-effects. In order to determine the impact of circulating anticholinergic activity on cognitive performance, 28 geropsychiatric inpatients underwent cognitive testing at different levels of anticholinergic serum activity. In 10 subjects with a diagnosis of probable Alzheimer's disease, significant deterioration of selected cognitive functions was observed at anticholinergic serum levels that caused no dysfunction in the 18 non-demented subjects. The data suggest that non-demented elderly patients with psychiatric problems tolerate psychotropic pharmacotherapy without significant negative impact on their cognitive competency. By contrast, patients with Alzheimer's disease are at risk of additional impairment. The introduction of anticholinergic serum activity as a monitoring technique for safe psychopharmacotherapy in geriatric patients is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02190089
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