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  • 1
    Digitale Medien
    Digitale Medien
    Fractionation of the liver extract on sephadex G25 (1962)
    Springer
    Cellular and molecular life sciences 18 (1962), S. 568-569 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Zusammenfassung Es werden einige niedrigmolekulare Stoffe aus Rattenleberextrakt nach der Sephadex G25-Fraktionierung beschrieben. Die Lokalisierung von Zukker, Aminosäuren, Peptiden, Nukleopeptiden und verwandter Stoffe wurde im Elutionsdiagramm vorgenommen.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02172185
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  • 2
    Digitale Medien
    Digitale Medien
    Isolation of the missing 5′-end of the encoding region of the bovine leukemia virus cell receptor gene (1994)
    Springer
    Archives of virology 138 (1994), S. 379-383 
    Details
    ISSN: 1432-8798
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The missing 5′-end of the encoding region of the bovine leukemia virus (BLV) cell receptor gene (BLVRcp1/5′) was isolated from a lambda gt11 cDNA library using the32P-labeledEcoRI-SamI fragment corresponding to the 5′-end of a 2.3 kbp cDNA fragment encoding the binding domain of the bovine leukemia virus cell receptor gene (BLVRcp1). The nucleotide and amino acid sequence analysis of the BLVRcp1/5′ cDNA revealed that the 1058 bpEcoRI fragment at its 5′-end contained a new 114 amino acid long sequence, and at its 3′-end contained a completely identical 88 amino acid overlapping region with the 5′-end of the BLVRcp1 cDNA. The combined sequences of both cDNAs represent the whole encoding region of the BLV cell receptor gene. The longest open reading frame of the BLV cell receptor gene encodes a protein containing 843 amino acids with a calculated molecular mass of 94.2 kDa which concurs with experimentally detected native BLV receptor protein. Search for homology has shown that about 250 bp of the BLV cell receptor gene is highly homologous to Venter's tag sequences of an unidentified gene from the human brain library.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01379141
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  • 3
    Digitale Medien
    Digitale Medien
    The human homologue of the bovine leukemia virus receptor BLVRcp1 is the δ-subunit of adaptor-related AP-3 protein that does not bind the BVLgp51 (1999)
    Springer
    Archives of virology 144 (1999), S. 2013-2022 
    Details
    ISSN: 1432-8798
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary.  The relationship between the putative bovine leukemia virus receptor gene (BVLRcp) and the susceptibility of human cells to BLV infection was studied. Three cDNA clones encoding different portions of the human equivalent of bovine BLVRcp1 were isolated by DNA-DNA hybridization by comparison of the human cDNA clones to bovine BLVRcp1. Amino acid sequence indicated that the human sequence encodes the $\trdelta$ subunit of the AP-3 adaptor-related protein. When the recombinant human homologue BLVRcp2 was expressed in E. coli, it failed to bind the BLVgp51. However, the BVLVgp51 binding ability was restored when the chimerical BLVRcp molecule was prepared by exchanging 5′ ends between bovine and human BLVRcp cDNAs. This finding implies that this BLVgp51 binding site is present only on the bovine BLVRcp and therefore its human homologue cannot be recognized by BLVgp51. This might also explain the resistance of human cells to BLV infection.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s007050050722
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  • 4
    Digitale Medien
    Digitale Medien
    Avian sarcoma virus transformed hamster cells resistant to bromodeoxyuridine and deficient in thymidine kinase activity (1973)
    Springer
    Archives of virology 41 (1973), S. 40-51 
    Details
    ISSN: 1432-8798
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Hamster cells transformed with the Schmidt-Ruppin strain of avian sarcoma virus were selected for resistance to 5-bromodeoxyuridine (BUDR). The resistant cell lines Ha(SR)BU-25 and Ha(SR)BU-100, proliferated in the presence of 25 and 100 μg/ml BUDR, respectively. The resistant cells were deficient in thymidine kinase activity. They did not grow in HATG medium and did not incorporate labelled thymidine into DNA. Several single-cell clones were isolated in medium containing 100 μg/ml BUDR from Ha(SR)BU-100 cells. These isolated cell clones differed in morphology and modal number of chromosomes from each other. None of the clones incorporated thymidine into DNA. The BUDR resistant cells were tested for their tumorigenicity in young hamsters. The number of cells needed for induction of tumor growth was higher with the BUDR resistant cells than with original clone of Ha(SR) cells. All clones of thymidine kinase deficient cells were tested for the presence of the virus genome by fusion with chicken embryo cells. All clones of Ha(SR)BU-100 cells contained the virus genome, and infectious virus could be rescued from these cells. Therefore, the genome of avian sarcoma virus can persist in virogenic hamster cells growing in the presence of 5-bromodeoxyuridine. These virogenic cells deficient in thymidine kinase activity are useful for preparation of cell hybrids.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01249927
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