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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Marine biology 117 (1993), S. 409-414 
    ISSN: 1432-1793
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The reproductive cycle of the bipolar sipunculan Golfingia margaritacea collected from Ushuaia, Argentina (54°49′ S; 68°13′W) in 1986 and 1987 is reported. The population sampled showed a sex ratio of 1:1. Males, however, frequently outnumbered females. Measurements of coelomic oocytes delineated an annual reproductive cycle. Small oocytes were present in the coelom all year: a subpopulation began to increase size about the middle of spring and reached its maximum size in late summer. Spawns may occur from the end February to April. May is characterized by resorption of large oocytes. Monthy monitoring of the gonads revealed mitotic activity and a continuous release of gametocytes to the coelom. Parasites were detected in the gonads. Large coelomic oocytes were also present in the coelom during the same season in the Northern and Southern Hemispheres, but egg sizes were significantly larger in boreal populations.
    Materialart: Digitale Medien
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  • 2
    ISSN: 1432-1793
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Mineral composition, granulometry, cohesion, relative and absolute density, and the pH of samples of the Santa Elena sedimentary rock shoal (37°56′02″ S; 58°11′35″ W; Argentina) were determined in order to relate the endolithic fauna with the properties of the substrate. Twenty three samples were collected in December 1987, applying a systematic sampling method to an intertidal area of 5 500 m2. The mineral composition was determined using x-ray diffraction. Cohesion was determined by visual evaluation of the disintegration of the sample following various periods of immersion in water and by recording the resistance to compressive fracture according to the American Society for Testing and Materials (ASTM) standard. The ASTM standard was also followed for measurement of absolute and relative densities and porosity. The rock was ground up in distilled water and the pH of the resulting liquid measured over a period of 24 h. The data were analysed using numerical taxonomy, and in a supplementary study a granulometric analysis was attempted using five representative samples. The endolithic species selected were: the sipunculanThemiste petricola; the polychaetesPolydora sp. andPherusa sp., and the bivalvesLithophaga patagonica, Petricola patagonica, Saxicava solida, Barnea lamellosa, andPholadidea darwini. The mineral analysis indicated heterogeneous composition and spatial distribution characteristic of a loess. In terms of cohesion, the substrate displayed varying degrees of disintegration, with resistance ranging from zero to very high (254.6 kg/cm2). The endolithic faunaThemiste petricola, Polydora sp.,Pherusa sp.,Lithophaga patagonica, Petricola patagonica, andSaxicava solida were found in areas of low to very high cohesion, with or without calcite. The Pholadidae were found in areas of zero to low cohesion, with absence or traces of calcite. This study indicates the important role of cohesion in determining the distribution of the endolithic fauna.
    Materialart: Digitale Medien
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  • 3
    ISSN: 1043-4666
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Archives of toxicology 62 (1988), S. 291-294 
    ISSN: 1432-0738
    Schlagwort(e): Acetaminophen ; Cadmium ; β2-microglobulin ; Potentiation of toxicity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The possible interactions between acetaminophen and cadmium (Cd) on the kidney were investigated in female Sprague-Dawley rats. Acetaminophen was administered in the food at an average dose of 900 mg/kg and Cd in drinking water at the concentration of 200 ppm. The treatment with acetaminophen and Cd lasted 2 and 10 months, respectively. No interaction between Cd and acetaminophen was observed during the period of their concomitant administration: the increase in albuminuria caused by Cd and acetaminophen was additive, while the tubular impairment caused by acetaminophen (increased β2-microglobulinuria and decreased kidney concentrating ability) was not exacerbated by Cd. None of these treatments affected the glomerular filtration rate. Four months after the end of acetaminophen treatment, the renal changes had almost completely disappeared in the rats which had received the analgesic alone. Those continously exposed to Cd had developed slight tubular damage, as evidenced by an increased urinary excretion of β2-microglobulin and β-N-acetylglucosaminidase. By contrast, rats pretreated with acetaminophen for 2 months and exposed to Cd showed a marked increase in urinary excretion of albumin and β2-microglobulin, suggesting an interaction between both treatments. At the end of the study, only the interaction with β2-microglobulin excretion was still evident; that with the urinary excretion of β-N-acetylglucosaminidase and albumin having been masked by the chronic progessive nephrosis affecting most animals at that stage. As acetaminophen had no effect on the renal accumulation of Cd, it may be concluded that pretreatment with this analgesic at a dose causing slight tubular dysfunction renders rat kidney more sensitive to the nephrotoxic action of Cd. This observation may be of clinical relevance for population groups occupationally or environmentally exposed to Cd.
    Materialart: Digitale Medien
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Archives of toxicology 66 (1992), S. 272-278 
    ISSN: 1432-0738
    Schlagwort(e): Cd nephrotoxicity ; Albuminuria ; β2-Microglobulinuria ; Glomerular polyanion ; Proteinuria ; Enzymuria ; Alcian blue
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The relationship between proteinuria and glomerular polyanion (GPA) charge has been studied in a model of experimental cadmium (Cd) nephropathy. Female Sprague-Dawley rats were administered Cd in drinking water for up to 18 months. From month 2, the animals showed an elevation of albuminuria preceding by about 6 months the rise of urinary β2-microglobulin and IgG. The nephrotoxic action of Cd was not readily detectable on the basis of the urinary output of β-N-acetylglucosaminidase, alanine aminopeptidase and lactate dehydrogenase. These enzymes showed either little variation or were affected late in the intoxication process. Administration of Cd for 12 or 18 months did not impair the GFR. The glomerular origin of the albuminuria induced by Cd was demonstrated by estimating the glomerular filtration of rat or human (injected intravenously) albumin in rats whose tubular reabsorption had been blocked by a saturating dose of cytochrome C. The GPA charge was assessed by measuring the binding of the cationic dye, Alcian blue (AB), to membranes of isolated glomeruli. The sialic and sulfate content of these membranes was also determined. The Cd induced-albuminuria was negatively correlated (r=−0.73;n=37) with the AB binding to glomerular membranes, their sialic acid contentr=−0.39) but not with their sulfate content (r=−0.15). A negative correlation (r=−0,62;n=37) was also observed between the albuminuria and red blood cell membrane negative charges largely contributed by sialic acid. All these observations can be interpreted as the evidence that Cd enhances the glomerular filtration of proteins through a GPA depletion involving mainly sialic acid.
    Materialart: Digitale Medien
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  • 6
    Digitale Medien
    Digitale Medien
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 45 (1989), S. 782-785 
    ISSN: 1600-5759
    Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Thema: Chemie und Pharmazie , Geologie und Paläontologie , Physik
    Materialart: Digitale Medien
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  • 7
    Digitale Medien
    Digitale Medien
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 43 (1987), S. 1587-1589 
    ISSN: 1600-5759
    Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Thema: Chemie und Pharmazie , Geologie und Paläontologie , Physik
    Materialart: Digitale Medien
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  • 8
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    Unbekannt
    Leiden : Periodicals Archive Online (PAO)
    Arabica. 30 (1983) 267 
    ISSN: 0570-5398
    Thema: Allgemeine und vergleichende Sprach- und Literaturwissenschaft. Indogermanistik. Außereuropäische Sprachen und Literaturen , Ethnologie , Geschichte , Theologie und Religionswissenschaft
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Annals of hematology 64 (1992), S. 286-291 
    ISSN: 1432-0584
    Schlagwort(e): Myeloproliferative disorders ; Megakaryopoiesis ; Histopathology ; Bone marrow
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Histologic diagnoses from bone marrow biopsies were analyzed in a total of 1165 patients presenting with thrombocythemic platelet counts at initial examination. Two cut-off points suggested by the Polycythemia Vera Study Group to define thrombocythemia by platelet counts were compared: the former limiting value of 1000×109/l platelets versus the recently proposed value of 600×109/l. The percentage of all nonproliferative disorders was 41% under the lower, dropping to 11% under the high cut-off point. The respective figures for myeloproliferative disorders increased from 49% under the lower to 74% under the high limiting value. Primary thrombocythemia was included in 72% by the lower, and in only 40% by the high limiting value when classified by its histologic pattern in bone marrow biopsy. A striking decrease of platelet counts occurs, related to fiber increase, among each of three main groups of myeloproliferative disorders: in CML with megakaryocytic predominance from 40% down to 25%, in megakaryocytic-granulocytic myelosis (primary, i.e., agnogenic myelofibrosis) from 36.6% to 10%, and in primary thrombocythemia from 72.6% to 28.6% in cases with reticulin sclerosis.
    Materialart: Digitale Medien
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    European journal of clinical microbiology & infectious diseases 14 (1995), S. 703-706 
    ISSN: 1435-4373
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The recovery of aSalmonella enteritidis strain that acquired resistance to β-lactams (including cefotaxime), to aminoglycosides and to chloramphenicol subsequent to cefotaxime therapy is reported. This resistance pattern to β-lactams was due to the presence of an extended-spectrum β-lactamase. The isoelectric point of this extended-spectrum β-lactamase was 6.3. The resistance genes were located on a transferable high-molecular-weight plasmid.
    Materialart: Digitale Medien
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